Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.

Literature DB >> 20097067

Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.

Abstract

The first synthesis of 1-deaza-pyridoxal 5'-phosphate (2-formyl-3-hydroxy-4-methylbenzyl phosphate) is described. The chemoenzymatic approach described here is a reliable route to this important isosteric pyridoxal phosphate analogue. This work enables elucidation of the role of the pyridine nitrogen in pyridoxal 5'-phosphate dependent enzymes. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities: Chemical Species

Mesh：

Substances：

Year: 2010 PMID： 20097067 PMCID： PMC3357107 DOI： 10.1016/j.bmcl.2010.01.002

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

15 in total

1. Catalytic racemization of amino acids by pyridoxal and metal salts.

Authors: J OLIVARD; D E METZLER; E E SNELL
Journal: J Biol Chem Date: 1952-12 Impact factor: 5.157

Review 2. Pyridoxal enzymes: mechanistic diversity and uniformity.

Authors: H Hayashi
Journal: J Biochem Date: 1995-09 Impact factor: 3.387

3. Catalytic reactions involving azomethines. XII. Transamination of 1-methyl-3-hydroxy-4-formylpyridinium chloride.

Authors: J R Maley; T C Bruice
Journal: Arch Biochem Biophys Date: 1970-01 Impact factor: 4.013

4. Determination of the structure of alanine racemase from Bacillus stearothermophilus at 1.9-A resolution.

Authors: J P Shaw; G A Petsko; D Ringe
Journal: Biochemistry Date: 1997-02-11 Impact factor: 3.162

5. Kinetics and equilibria for the reactions of coenzymes with wild type and the Y70F mutant of Escherichia coli aspartate aminotransferase.

Authors: M D Toney; J F Kirsch
Journal: Biochemistry Date: 1991-07-30 Impact factor: 3.162

Review 6. Reaction specificity in pyridoxal phosphate enzymes.

Authors: Michael D Toney
Journal: Arch Biochem Biophys Date: 2005-01-01 Impact factor: 4.013

7. Aspartate-279 in aminolevulinate synthase affects enzyme catalysis through enhancing the function of the pyridoxal 5'-phosphate cofactor.

Authors: J Gong; G A Hunter; G C Ferreira
Journal: Biochemistry Date: 1998-03-10 Impact factor: 3.162

8. Characterization of the apparent negative co-operativity induced in Escherichia coli aspartate aminotransferase by the replacement of Asp222 with alanine. Evidence for an extremely slow conformational change.

Authors: J J Onuffer; J F Kirsch
Journal: Protein Eng Date: 1994-03

9. Comparison of the rate constants for general base catalyzed prototropy and racemization of the aldimine species formed from 3-hydroxypyridine-4-carboxaldehyde and alanine.

Authors: J E Dixon; T C Bruice
Journal: Biochemistry Date: 1973-11-06 Impact factor: 3.162

10. Role of an active site residue analyzed by combination of mutagenesis and coenzyme analog.

Authors: T Yano; Y Hinoue; V J Chen; D E Metzler; I Miyahara; K Hirotsu; H Kagamiyama
Journal: J Mol Biol Date: 1993-12-20 Impact factor: 5.469

5 in total

Review 1. Aspartate aminotransferase: an old dog teaches new tricks.

Authors: Michael D Toney
Journal: Arch Biochem Biophys Date: 2013-10-09 Impact factor: 4.013

Review 2. Controlling reaction specificity in pyridoxal phosphate enzymes.

Authors: Michael D Toney
Journal: Biochim Biophys Acta Date: 2011-06-06

3. Ground-state electronic destabilization via hyperconjugation in aspartate aminotransferase.

Authors: Wait R Griswold; Joan Nieto Castro; Andrew J Fisher; Michael D Toney
Journal: J Am Chem Soc Date: 2012-05-10 Impact factor: 15.419

4. The Nitrogen Atom of Vitamin B₆ Is Essential for the Catalysis of Radical Aminomutases.

Authors: Amarendra Nath Maity; Jun-Ru Chen; Quan-Yuan Li; Shyue-Chu Ke
Journal: Int J Mol Sci Date: 2022-05-06 Impact factor: 6.208

Review 5. Large-scale domain motions and pyridoxal-5'-phosphate assisted radical catalysis in coenzyme B12-dependent aminomutases.

Authors: Amarendra Nath Maity; Yung-Han Chen; Shyue-Chu Ke
Journal: Int J Mol Sci Date: 2014-02-20 Impact factor: 5.923

5 in total