PURPOSE: To elicit preference values for health states associated with Stage III colon cancer (CRC) and to explore the effect of neuropathy associated with current adjuvant treatment. METHODS: We used time trade-off (TTO) techniques to elicit preferences from 49 CRC patients and 49 community members. We elicited preferences for 7 health states: remission; adjuvant therapy with no, mild, moderate, and severe neuropathy; metastatic stable; and metastatic progressive disease. Mean TTO values were adjusted for the covariates age, education, and current health. RESULTS: Patients' adjusted mean TTO value for remission was 0.83; adjuvant chemotherapy health states ranged from 0.48 to 0.61. Significant differences were observed for both patient and community groups between TTO for remission and all adjuvant health states (P < 0.001), and between adjuvant therapy with no neuropathy and metastatic health states (P < or = 0.001). Across all health states, patients' values were on average 0.12 higher than community members (P < 0.05). CONCLUSIONS: The findings highlight the trade-offs between the disutility of adjuvant treatment, the higher utility of remission, and the severe utility loss during metastatic disease. The preference values obtained from this study will be useful for informing patients' treatment decisions and payer cost-utility analyses of adjuvant treatment for colon cancer.
PURPOSE: To elicit preference values for health states associated with Stage III colon cancer (CRC) and to explore the effect of neuropathy associated with current adjuvant treatment. METHODS: We used time trade-off (TTO) techniques to elicit preferences from 49 CRCpatients and 49 community members. We elicited preferences for 7 health states: remission; adjuvant therapy with no, mild, moderate, and severe neuropathy; metastatic stable; and metastatic progressive disease. Mean TTO values were adjusted for the covariates age, education, and current health. RESULTS:Patients' adjusted mean TTO value for remission was 0.83; adjuvant chemotherapy health states ranged from 0.48 to 0.61. Significant differences were observed for both patient and community groups between TTO for remission and all adjuvant health states (P < 0.001), and between adjuvant therapy with no neuropathy and metastatic health states (P < or = 0.001). Across all health states, patients' values were on average 0.12 higher than community members (P < 0.05). CONCLUSIONS: The findings highlight the trade-offs between the disutility of adjuvant treatment, the higher utility of remission, and the severe utility loss during metastatic disease. The preference values obtained from this study will be useful for informing patients' treatment decisions and payer cost-utility analyses of adjuvant treatment for colon cancer.
Authors: Sylvie M C van Osch; Peter P Wakker; Wilbert B van den Hout; Anne M Stiggelbout Journal: Med Decis Making Date: 2004 Sep-Oct Impact factor: 2.583
Authors: Dara Stein; F Joulain; S Naoshy; U Iqbal; N Muszbek; K A Payne; D Ferry; S H Goey Journal: Int J Colorectal Dis Date: 2014-08-01 Impact factor: 2.571
Authors: Steven R Alberts; Tiffany M Yu; Robert J Behrens; Lindsay A Renfro; Geetika Srivastava; Gamini S Soori; Shaker R Dakhil; Rex B Mowat; John P Kuebler; George P Kim; Miroslaw A Mazurczak; John Hornberger Journal: Pharmacoeconomics Date: 2014-12 Impact factor: 4.981