| Literature DB >> 20084456 |
Sachin G Modha1, Vaibhav P Mehta, Denis Ermolat'ev, Jan Balzarini, Kristof Van Hecke, Luc Van Meervelt, Erik Van der Eycken.
Abstract
The synthesis and biological activity of a hitherto unknown class of compounds, the imidazolylthiazolidin-4-ones, are described. A two-step procedure has been elaborated starting from our previously described 2-aminoimidazoles. The application of microwave irradiation has been proven to be beneficial for the condensation of the imine with mercaptoacetic acid leading to the formation of imidazolylthiazolidin-4-ones. None of the compounds showed antiviral activity at subtoxic concentrations. Several compounds displayed a moderate cytostatic activity. These data form the basis for further improvement of the potential antiproliferative activity of this class of compounds.Entities:
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Year: 2010 PMID： 20084456 DOI： 10.1007/s11030-009-9221-1
Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 3.364