| Literature DB >> 1353796 |
M V Diurno1, O Mazzoni, E Piscopo, A Calignano, F Giordano, A Bolognese.
Abstract
A new series of 2-(4- and 3-substituted phenyl)-3-[3-(N,N-dimethylamino) propyl]-1,3-thiazolidin-4-ones were synthesized, characterized, and evaluated for their ability to inhibit the contractions induced by histamine on guinea pig ileum. The measurement of pA2 values suggested that the reported compounds showed H1-antagonism. The more active compounds 5, 9, and 13 exhibited activity close to that of mepyramine.Entities:
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Year: 1992 PMID： 1353796 DOI： 10.1021/jm00093a025
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446