Literature DB >> 20065954

Personalized genomic information: preparing for the future of genetic medicine.

Alan E Guttmacher1, Amy L McGuire, Bruce Ponder, Kári Stefánsson.   

Abstract

The falling cost of sequencing means that we are rapidly approaching an era in which access to personalized genomic information is likely to be widespread. Here, four experts with different insights into the field of genomic medicine answer questions about the prospects for using this type of information. Their responses highlight the diverse range of issues that must be addressed - ranging from scientific to ethical and logistical - to ensure that the potential benefits of personal genomic information outweigh the costs to both individuals and societies.

Mesh：

Year:  2010        PMID： 20065954     DOI： 10.1038/nrg2735

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  25 in total

1.  Complement factor H polymorphism in age-related macular degeneration.

Authors:  Robert J Klein; Caroline Zeiss; Emily Y Chew; Jen-Yue Tsai; Richard S Sackler; Chad Haynes; Alice K Henning; John Paul SanGiovanni; Shrikant M Mane; Susan T Mayne; Michael B Bracken; Frederick L Ferris; Jurg Ott; Colin Barnstable; Josephine Hoh
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

2.  A common variant on chromosome 9p21 affects the risk of myocardial infarction.

Authors:  Anna Helgadottir; Gudmar Thorleifsson; Andrei Manolescu; Solveig Gretarsdottir; Thorarinn Blondal; Aslaug Jonasdottir; Adalbjorg Jonasdottir; Asgeir Sigurdsson; Adam Baker; Arnar Palsson; Gisli Masson; Daniel F Gudbjartsson; Kristinn P Magnusson; Karl Andersen; Allan I Levey; Valgerdur M Backman; Sigurborg Matthiasdottir; Thorbjorg Jonsdottir; Stefan Palsson; Helga Einarsdottir; Steinunn Gunnarsdottir; Arnaldur Gylfason; Viola Vaccarino; W Craig Hooper; Muredach P Reilly; Christopher B Granger; Harland Austin; Daniel J Rader; Svati H Shah; Arshed A Quyyumi; Jeffrey R Gulcher; Gudmundur Thorgeirsson; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Science       Date:  2007-05-03       Impact factor: 47.728

Review 3.  Newborn screening for genetic disorders.

Authors:  Paul M Fernhoff
Journal:  Pediatr Clin North Am       Date:  2009-06       Impact factor: 3.278

Review 4.  A network view of disease and compound screening.

Authors:  Eric E Schadt; Stephen H Friend; David A Shaywitz
Journal:  Nat Rev Drug Discov       Date:  2009-04       Impact factor: 84.694

5.  Polygenes, risk prediction, and targeted prevention of breast cancer.

Authors:  Paul D P Pharoah; Antonis C Antoniou; Douglas F Easton; Bruce A J Ponder
Journal:  N Engl J Med       Date:  2008-06-26       Impact factor: 91.245

Review 6.  Cascade effects of medical technology.

Authors:  Richard A Deyo
Journal:  Annu Rev Public Health       Date:  2001-10-25       Impact factor: 21.981

Review 7.  Common and rare variants in multifactorial susceptibility to common diseases.

Authors:  Walter Bodmer; Carolina Bonilla
Journal:  Nat Genet       Date:  2008-06       Impact factor: 38.330

Review 8.  Clinically available pharmacogenomics tests.

Authors:  D A Flockhart; T Skaar; D S Berlin; T E Klein; A T Nguyen
Journal:  Clin Pharmacol Ther       Date:  2009-04-15       Impact factor: 6.875

9.  Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

Authors:  Sekar Kathiresan; Benjamin F Voight; Shaun Purcell; Kiran Musunuru; Diego Ardissino; Pier M Mannucci; Sonia Anand; James C Engert; Nilesh J Samani; Heribert Schunkert; Jeanette Erdmann; Muredach P Reilly; Daniel J Rader; Thomas Morgan; John A Spertus; Monika Stoll; Domenico Girelli; Pascal P McKeown; Chris C Patterson; David S Siscovick; Christopher J O'Donnell; Roberto Elosua; Leena Peltonen; Veikko Salomaa; Stephen M Schwartz; Olle Melander; David Altshuler; Diego Ardissino; Pier Angelica Merlini; Carlo Berzuini; Luisa Bernardinelli; Flora Peyvandi; Marco Tubaro; Patrizia Celli; Maurizio Ferrario; Raffaela Fetiveau; Nicola Marziliano; Giorgio Casari; Michele Galli; Flavio Ribichini; Marco Rossi; Francesco Bernardi; Pietro Zonzin; Alberto Piazza; Pier M Mannucci; Stephen M Schwartz; David S Siscovick; Jean Yee; Yechiel Friedlander; Roberto Elosua; Jaume Marrugat; Gavin Lucas; Isaac Subirana; Joan Sala; Rafael Ramos; Sekar Kathiresan; James B Meigs; Gordon Williams; David M Nathan; Calum A MacRae; Christopher J O'Donnell; Veikko Salomaa; Aki S Havulinna; Leena Peltonen; Olle Melander; Goran Berglund; Benjamin F Voight; Sekar Kathiresan; Joel N Hirschhorn; Rosanna Asselta; Stefano Duga; Marta Spreafico; Kiran Musunuru; Mark J Daly; Shaun Purcell; Benjamin F Voight; Shaun Purcell; James Nemesh; Joshua M Korn; Steven A McCarroll; Stephen M Schwartz; Jean Yee; Sekar Kathiresan; Gavin Lucas; Isaac Subirana; Roberto Elosua; Aarti Surti; Candace Guiducci; Lauren Gianniny; Daniel Mirel; Melissa Parkin; Noel Burtt; Stacey B Gabriel; Nilesh J Samani; John R Thompson; Peter S Braund; Benjamin J Wright; Anthony J Balmforth; Stephen G Ball; Alistair S Hall; Heribert Schunkert; Jeanette Erdmann; Patrick Linsel-Nitschke; Wolfgang Lieb; Andreas Ziegler; Inke König; Christian Hengstenberg; Marcus Fischer; Klaus Stark; Anika Grosshennig; Michael Preuss; H-Erich Wichmann; Stefan Schreiber; Heribert Schunkert; Nilesh J Samani; Jeanette Erdmann; Willem Ouwehand; Christian Hengstenberg; Panos Deloukas; Michael Scholz; Francois Cambien; Muredach P Reilly; Mingyao Li; Zhen Chen; Robert Wilensky; William Matthai; Atif Qasim; Hakon H Hakonarson; Joe Devaney; Mary-Susan Burnett; Augusto D Pichard; Kenneth M Kent; Lowell Satler; Joseph M Lindsay; Ron Waksman; Christopher W Knouff; Dawn M Waterworth; Max C Walker; Vincent Mooser; Stephen E Epstein; Daniel J Rader; Thomas Scheffold; Klaus Berger; Monika Stoll; Andreas Huge; Domenico Girelli; Nicola Martinelli; Oliviero Olivieri; Roberto Corrocher; Thomas Morgan; John A Spertus; Pascal McKeown; Chris C Patterson; Heribert Schunkert; Erdmann Erdmann; Patrick Linsel-Nitschke; Wolfgang Lieb; Andreas Ziegler; Inke R König; Christian Hengstenberg; Marcus Fischer; Klaus Stark; Anika Grosshennig; Michael Preuss; H-Erich Wichmann; Stefan Schreiber; Hilma Hólm; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Kari Stefansson; James C Engert; Ron Do; Changchun Xie; Sonia Anand; Sekar Kathiresan; Diego Ardissino; Pier M Mannucci; David Siscovick; Christopher J O'Donnell; Nilesh J Samani; Olle Melander; Roberto Elosua; Leena Peltonen; Veikko Salomaa; Stephen M Schwartz; David Altshuler
Journal:  Nat Genet       Date:  2009-02-08       Impact factor: 38.330

10.  Estimation of the warfarin dose with clinical and pharmacogenetic data.

Authors:  T E Klein; R B Altman; N Eriksson; B F Gage; S E Kimmel; M-T M Lee; N A Limdi; D Page; D M Roden; M J Wagner; M D Caldwell; J A Johnson
Journal:  N Engl J Med       Date:  2009-02-19       Impact factor: 91.245
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  47 in total

1.  Genetic self knowledge and the future of epidemiologic confounding.

Authors:  Tyler J VanderWeele; Tyler Vander Weele
Journal:  Am J Hum Genet       Date:  2010-08-13       Impact factor: 11.025

2.  Preferences for return of incidental findings from genome sequencing among women diagnosed with breast cancer at a young age.

Authors:  K A Kaphingst; J Ivanovich; B B Biesecker; R Dresser; J Seo; L G Dressler; P J Goodfellow; M S Goodman
Journal:  Clin Genet       Date:  2015-05-05       Impact factor: 4.438

3.  Flexible approaches for teaching computational genomics in a health information management program.

Authors:  Leming Zhou; Valerie Watzlaf; Mervat Abdelhak
Journal:  Perspect Health Inf Manag       Date:  2013-07-01

Review 4.  Communicating genetic risk information for common disorders in the era of genomic medicine.

Authors:  Denise M Lautenbach; Kurt D Christensen; Jeffrey A Sparks; Robert C Green
Journal:  Annu Rev Genomics Hum Genet       Date:  2013       Impact factor: 8.929

5.  Risk for Patient Harm in Canadian Genetic Counseling Practice: It's Time to Consider Regulation.

Authors:  Andrea L Shugar; Nada Quercia; Christopher Trevors; Marina M Rabideau; Sohnee Ahmed
Journal:  J Genet Couns       Date:  2016-06-07       Impact factor: 2.537

6.  More than Moore's Mores: Computers, Genomics, and the Embrace of Innovation.

Authors:  Joseph November
Journal:  J Hist Biol       Date:  2018-12       Impact factor: 1.326

Review 7.  Genetic architecture of colorectal cancer.

Authors:  Ulrike Peters; Stephanie Bien; Niha Zubair
Journal:  Gut       Date:  2015-07-17       Impact factor: 23.059

8.  Management of incidental findings in clinical genomic sequencing.

Authors:  Joel B Krier; Robert C Green
Journal:  Curr Protoc Hum Genet       Date:  2013

9.  Genetics patients' perspectives on clinical genomic testing.

Authors:  Michelle L McGowan; Allison Glinka; Janelle Highland; George Asaad; Richard R Sharp
Journal:  Per Med       Date:  2013-06-01       Impact factor: 2.512

10.  EMR documentation of physician-patient communication following genomic counseling for actionable complex disease and pharmacogenomic results.

Authors:  K Sweet; A C Sturm; T Schmidlen; S Hovick; J Peng; K Manickam; A Salikhova; J McElroy; L Scheinfeldt; A E Toland; J S Roberts; M Christman
Journal:  Clin Genet       Date:  2016-07-28       Impact factor: 4.438
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