| Literature DB >> 20064371 |
Abraham L Brass1, I-Chueh Huang, Yair Benita, Sinu P John, Manoj N Krishnan, Eric M Feeley, Bethany J Ryan, Jessica L Weyer, Louise van der Weyden, Erol Fikrig, David J Adams, Ramnik J Xavier, Michael Farzan, Stephen J Elledge.
Abstract
Influenza viruses exploit host cell machinery to replicate, resulting in epidemics of respiratory illness. In turn, the host expresses antiviral restriction factors to defend against infection. To find host cell modifiers of influenza A H1N1 viral infection, we used a functional genomic screen and identified over 120 influenza A virus-dependency factors with roles in endosomal acidification, vesicular trafficking, mitochondrial metabolism, and RNA splicing. We discovered that the interferon-inducible transmembrane proteins IFITM1, 2, and 3 restrict an early step in influenza A viral replication. The IFITM proteins confer basal resistance to influenza A virus but are also inducible by interferons type I and II and are critical for interferon's virustatic actions. Further characterization revealed that the IFITM proteins inhibit the early replication of flaviviruses, including dengue virus and West Nile virus. Collectively this work identifies a family of antiviral restriction factors that mediate cellular innate immunity to at least three major human pathogens. Copyright 2009 Elsevier Inc. All rights reserved.Entities:
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Year: 2009 PMID： 20064371 PMCID： PMC2824905 DOI： 10.1016/j.cell.2009.12.017
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582