Literature DB >> 2005909

The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants.

E M Stone1, M J Swanson, A M Romeo, J B Hicks, R Sternglanz.   

Abstract

The SIR1 gene product of Saccharomyces cerevisiae is one of several proteins involved in repressing transcription of the silent mating-type genes. Strains with mutations in the genes coding for these proteins are defective in mating due to derepression of the silent loci. We have found that overexpression of the SIR1 gene suppresses the mating defects of several of these mutants, including nat1 and ard1 mutants (the products of these two genes are responsible for N-terminal acetylation of a subset of yeast proteins), certain sir3 mutants, and a histone H4 mutant. The SIR1 gene has been sequenced and found to contain an open reading frame coding for a 678-amino-acid protein.

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Year:  1991        PMID： 2005909      PMCID： PMC359924          DOI： 10.1128/mcb.11.4.2253-2262.1991

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  27 in total

1.  Characterization of a "silencer" in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer.

Authors:  A H Brand; L Breeden; J Abraham; R Sternglanz; K Nasmyth
Journal:  Cell       Date:  1985-05       Impact factor: 41.582

2.  The role of DNA replication in the repression of the yeast mating-type silent loci.

Authors:  A M Miller; R Sternglanz; K A Nasmyth
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1984

3.  Regulation of mating-type information in yeast. Negative control requiring sequences both 5' and 3' to the regulated region.

Authors:  J Abraham; K A Nasmyth; J N Strathern; A J Klar; J B Hicks
Journal:  J Mol Biol       Date:  1984-07-05       Impact factor: 5.469

4.  Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locus.

Authors:  J N Strathern; A J Klar; J B Hicks; J A Abraham; J M Ivy; K A Nasmyth; C McGill
Journal:  Cell       Date:  1982-11       Impact factor: 41.582

5.  The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways.

Authors:  M Whiteway; J W Szostak
Journal:  Cell       Date:  1985-12       Impact factor: 41.582

6.  Identification of sites required for repression of a silent mating type locus in yeast.

Authors:  J B Feldman; J B Hicks; J R Broach
Journal:  J Mol Biol       Date:  1984-10-05       Impact factor: 5.469

7.  A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci.

Authors:  J Rine; J N Strathern; J B Hicks; I Herskowitz
Journal:  Genetics       Date:  1979-12       Impact factor: 4.562

8.  Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts.

Authors:  C J Langford; D Gallwitz
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

9.  Identification of silencer binding proteins from yeast: possible roles in SIR control and DNA replication.

Authors:  D Shore; D J Stillman; A H Brand; K A Nasmyth
Journal:  EMBO J       Date:  1987-02       Impact factor: 11.598

10.  Characterization of two genes required for the position-effect control of yeast mating-type genes.

Authors:  D Shore; M Squire; K A Nasmyth
Journal:  EMBO J       Date:  1984-12-01       Impact factor: 11.598
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  53 in total

1.  SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.

Authors:  E Y Xu; S Kim; D H Rivier
Journal:  Genetics       Date:  1999-09       Impact factor: 4.562

2.  Cohabitation of insulators and silencing elements in yeast subtelomeric regions.

Authors:  G Fourel; E Revardel; C E Koering; E Gilson
Journal:  EMBO J       Date:  1999-05-04       Impact factor: 11.598

3.  Identification of a member of a DNA-dependent ATPase family that causes interference with silencing.

Authors:  Z Zhang; A R Buchman
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

4.  One-hybrid screens at the Saccharomyces cerevisiae HMR locus identify novel transcriptional silencing factors.

Authors:  Erik D Andrulis; David C Zappulla; Krassimira Alexieva-Botcheva; Carlos Evangelista; Rolf Sternglanz
Journal:  Genetics       Date:  2004-01       Impact factor: 4.562

5.  Importance of the Sir3 N terminus and its acetylation for yeast transcriptional silencing.

Authors:  Xiaorong Wang; Jessica J Connelly; Chia-Lin Wang; Rolf Sternglanz
Journal:  Genetics       Date:  2004-09       Impact factor: 4.562

6.  New alleles of SIR2 define cell-cycle-specific silencing functions.

Authors:  Mirela Matecic; Kristen Martins-Taylor; Merrit Hickman; Jason Tanny; Danesh Moazed; Scott G Holmes
Journal:  Genetics       Date:  2006-06-18       Impact factor: 4.562

7.  Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.

Authors:  Jennifer E G Gallagher; Joshua E Babiarz; Leonid Teytelman; Kenneth H Wolfe; Jasper Rine
Journal:  Genetics       Date:  2009-01-26       Impact factor: 4.562

8.  The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides.

Authors:  Matthias Gautschi; Sören Just; Andrej Mun; Suzanne Ross; Peter Rücknagel; Yves Dubaquié; Ann Ehrenhofer-Murray; Sabine Rospert
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

9.  Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain.

Authors:  Jessica J Connelly; Peihua Yuan; Hao-Chi Hsu; Zhizhong Li; Rui-Ming Xu; Rolf Sternglanz
Journal:  Mol Cell Biol       Date:  2006-04       Impact factor: 4.272

10.  Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1.

Authors:  Francisco Conde; Pedro A San-Segundo
Journal:  Genetics       Date:  2008-06-18       Impact factor: 4.562
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