Literature DB >> 15454564

Importance of the Sir3 N terminus and its acetylation for yeast transcriptional silencing.

Xiaorong Wang1, Jessica J Connelly, Chia-Lin Wang, Rolf Sternglanz.   

Abstract

The N-terminal alanine residues of the silencing protein Sir3 and of Orc1 are acetylated by the NatA Nalpha-acetyltransferase. Mutations demonstrate that the N terminus of Sir3 is important for its function. Sir3 and, perhaps, also Orc1 are the NatA substrates whose lack of acetylation in ard1 and nat1 mutants explains the silencing defect of those mutants.

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Year:  2004        PMID： 15454564      PMCID： PMC1448112          DOI： 10.1534/genetics.104.028803

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  23 in total

1.  Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae.

Authors:  Laura N Rusché; Ann L Kirchmaier; Jasper Rine
Journal:  Mol Biol Cell       Date:  2002-07       Impact factor: 4.138

Review 2.  The establishment, inheritance, and function of silenced chromatin in Saccharomyces cerevisiae.

Authors:  Laura N Rusche; Ann L Kirchmaier; Jasper Rine
Journal:  Annu Rev Biochem       Date:  2003-03-27       Impact factor: 23.643

3.  The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus.

Authors:  M Whiteway; R Freedman; S Van Arsdell; J W Szostak; J Thorner
Journal:  Mol Cell Biol       Date:  1987-10       Impact factor: 4.272

4.  The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants.

Authors:  E M Stone; M J Swanson; A M Romeo; J B Hicks; R Sternglanz
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

5.  Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation.

Authors:  Georg J Hoppe; Jason C Tanny; Adam D Rudner; Scott A Gerber; Sherwin Danaie; Steven P Gygi; Danesh Moazed
Journal:  Mol Cell Biol       Date:  2002-06       Impact factor: 4.272

6.  An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A.

Authors:  Ok-kyu Song; Xiaorong Wang; Jakob H Waterborg; Rolf Sternglanz
Journal:  J Biol Chem       Date:  2003-08-12       Impact factor: 5.157

7.  Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.

Authors:  O M Aparicio; B L Billington; D E Gottschling
Journal:  Cell       Date:  1991-09-20       Impact factor: 41.582

8.  The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain.

Authors:  Melissa E Bose; Kristopher H McConnell; Kelly A Gardner-Aukema; Ulrika Müller; Michael Weinreich; James L Keck; Catherine A Fox
Journal:  Mol Cell Biol       Date:  2004-01       Impact factor: 4.272

Review 9.  N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins.

Authors:  Bogdan Polevoda; Fred Sherman
Journal:  J Mol Biol       Date:  2003-01-24       Impact factor: 5.469

10.  Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast.

Authors:  J R Mullen; P S Kayne; R P Moerschell; S Tsunasawa; M Gribskov; M Colavito-Shepanski; M Grunstein; F Sherman; R Sternglanz
Journal:  EMBO J       Date:  1989-07       Impact factor: 11.598
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  39 in total

1.  Genome-wide screen for inner nuclear membrane protein targeting in Saccharomyces cerevisiae: roles for N-acetylation and an integral membrane protein.

Authors:  Athulaprabha Murthi; Anita K Hopper
Journal:  Genetics       Date:  2005-05-23       Impact factor: 4.562

Review 2.  Chromatin architectural proteins.

Authors:  Steven J McBryant; Valerie H Adams; Jeffrey C Hansen
Journal:  Chromosome Res       Date:  2006       Impact factor: 5.239

3.  Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism.

Authors:  Ryan M Raisner; Hiten D Madhani
Journal:  Genetics       Date:  2008-08-09       Impact factor: 4.562

4.  Sir3 and epigenetic inheritance of silent chromatin in Saccharomyces cerevisiae.

Authors:  Tina Motwani; Minakshi Poddar; Scott G Holmes
Journal:  Mol Cell Biol       Date:  2012-05-14       Impact factor: 4.272

5.  Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain.

Authors:  Dongxue Yang; Qianglin Fang; Mingzhu Wang; Ren Ren; Hong Wang; Meng He; Youwei Sun; Na Yang; Rui-Ming Xu
Journal:  Nat Struct Mol Biol       Date:  2013-08-11       Impact factor: 15.369

6.  Fueling transcriptional silencing with Gas1.

Authors:  Rebecca J Burgess; Michael P Guy; Zhiguo Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-30       Impact factor: 11.205

7.  Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain.

Authors:  Jessica J Connelly; Peihua Yuan; Hao-Chi Hsu; Zhizhong Li; Rui-Ming Xu; Rolf Sternglanz
Journal:  Mol Cell Biol       Date:  2006-04       Impact factor: 4.272

Review 8.  Silent information regulator 3: the Goldilocks of the silencing complex.

Authors:  Anne Norris; Jef D Boeke
Journal:  Genes Dev       Date:  2010-01-15       Impact factor: 11.361

9.  Protein N-terminal acetylation: NAT 2007-2008 Symposia.

Authors:  Thomas Arnesen
Journal:  BMC Proc       Date:  2009-08-04

10.  Mutational analysis of the Sir3 BAH domain reveals multiple points of interaction with nucleosomes.

Authors:  Vinaya Sampath; Peihua Yuan; Isabel X Wang; Evelyn Prugar; Fred van Leeuwen; Rolf Sternglanz
Journal:  Mol Cell Biol       Date:  2009-03-09       Impact factor: 4.272
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