Literature DB >> 17943924

Pyrrolidinyl-spirooxindole natural products as inspirations for the development of potential therapeutic agents.

Chris V Galliford1, Karl A Scheidt.   

Abstract

The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17943924     DOI： 10.1002/anie.200701342

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  121 in total

1.  Alpha-arylation of 3-aryloxindoles.

Authors:  Cheng-Kang Mai; Matthew F Sammons; Tarek Sammakia
Journal:  Org Lett       Date:  2010-05-21       Impact factor: 6.005

2.  Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products.

Authors:  Andrey P Antonchick; Claas Gerding-Reimers; Mario Catarinella; Markus Schürmann; Hans Preut; Slava Ziegler; Daniel Rauh; Herbert Waldmann
Journal:  Nat Chem       Date:  2010-07-11       Impact factor: 24.427

3.  Terminating Catalytic Asymmetric Heck Cyclizations by Stereoselective Intramolecular Capture of η-Allylpalladium Intermediates: Total Synthesis of (-)-Spirotryprostatin B and Three Stereoisomers.

Authors:  Larry E Overman; Mark D Rosen
Journal:  Tetrahedron       Date:  2010-08-14       Impact factor: 2.457

4.  Base catalyzed multicomponent synthesis of spiroheterocycles with fused heterosystems.

Authors:  Anand Kumar Arya; Mahendra Kumar
Journal:  Mol Divers       Date:  2011-03-20       Impact factor: 2.943

5.  Asymmetric synthesis of allenyl oxindoles and spirooxindoles by a catalytic enantioselective Saucy-Marbet Claisen rearrangement.

Authors:  Trung Cao; Joshua Deitch; Elizabeth C Linton; Marisa C Kozlowski
Journal:  Angew Chem Int Ed Engl       Date:  2012-01-27       Impact factor: 15.336

6.  A green synthetic approach toward the synthesis of structurally diverse spirooxindole derivative libraries under catalyst-free conditions.

Authors:  Nazia Kausar; Abdulla Al Masum; Md Maidul Islam; Asish R Das
Journal:  Mol Divers       Date:  2017-02-11       Impact factor: 2.943

7.  FeCl₃-catalyzed [3+3] annulation between 3-oxirane-indolin-2-ones and nitrones to construct spiro[1,4,2-dioxazinan]oxindoles.

Authors:  Jingmiao Yu; Chun Cai
Journal:  Mol Divers       Date:  2017-04-24       Impact factor: 2.943

8.  Multicomponent reaction discovery: three-component synthesis of spirooxindoles.

Authors:  Bo Liang; Srinivas Kalidindi; John A Porco; Corey R J Stephenson
Journal:  Org Lett       Date:  2010-02-05       Impact factor: 6.005

Review 9.  Therapeutic Potential of Spirooxindoles as Antiviral Agents.

Authors:  Na Ye; Haiying Chen; Eric A Wold; Pei-Yong Shi; Jia Zhou
Journal:  ACS Infect Dis       Date:  2016-05-05       Impact factor: 5.084

10.  A thermally-induced, tandem [3,3]-sigmatropic rearrangement/[2 + 2] cycloaddition approach to carbocyclic spirooxindoles.

Authors:  Kay M Brummond; Joshua M Osbourn
Journal:  Beilstein J Org Chem       Date:  2010-04-08       Impact factor: 2.883
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.