Literature DB >> 20039641

Combining asymmetric catalysis with natural product functionalization through enantioselective alpha-fluorination.

Jeremy Erb1, Ethan Alden-Danforth, Nathan Kopf, Michael T Scerba, Thomas Lectka.   

Abstract

An examination into the derivatization of various natural products using newly developed alpha-fluorination methodology is disclosed. An activated ketene enolate, generated from an acid chloride, is allowed to react with an electrophilic fluorine source (NFSi). Quenching the reaction with a nucleophilic natural product produces biologically relevant alpha-fluorinated carbonyl derivatives of select chemotherapeutics, antibiotics, and other pharmaceuticals.

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Year:  2010        PMID： 20039641      PMCID： PMC3443555          DOI： 10.1021/jo9024072

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  22 in total

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