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Literature DB >> 9383461

Mitomycin C: small, fast and deadly (but very selective).

Abstract

Mitomycin C, an important antitumor drug and antibiotic, has an extraordinary ability to crosslink DNA with high efficiency and absolute specificity for the sequence CpG. Recent results have shown how mitomycin C crosslinks DNA, and why the sequence specificity is so complete. This new understanding may allow the design of agents that mimic mitomycin C's economy of structure and can crosslink other sequences.

Entities: Chemical

Mesh：

Substances：

Year: 1995 PMID： 9383461 DOI： 10.1016/1074-5521(95)90120-5

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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Cited

152 in total

1. Spatially directed guidance of stem cell population migration by immobilized patterns of growth factors.

Authors: Eric D Miller; Kang Li; Takeo Kanade; Lee E Weiss; Lynn M Walker; Phil G Campbell
Journal: Biomaterials Date: 2011-01-26 Impact factor: 12.479

2. A general strategy for target-promoted alkylation in biological systems.

Authors: Qibing Zhou; Steven E Rokita
Journal: Proc Natl Acad Sci U S A Date: 2003-12-12 Impact factor: 11.205

3. ROS-inducible DNA cross-linking agent as a new anticancer prodrug building block.

Authors: Sheng Cao; Yibin Wang; Xiaohua Peng
Journal: Chemistry Date: 2012-02-29 Impact factor: 5.236

4. Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.

Authors: Mostafa I Fekry; Jozsef Szekely; Sanjay Dutta; Leonid Breydo; Hong Zang; Kent S Gates
Journal: J Am Chem Soc Date: 2011-10-18 Impact factor: 15.419

Mitomycin C: small, fast and deadly (but very selective).

1. Spatially directed guidance of stem cell population migration by immobilized patterns of growth factors.

2. A general strategy for target-promoted alkylation in biological systems.

3. ROS-inducible DNA cross-linking agent as a new anticancer prodrug building block.

4. Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.

5. Exposure to anticancer drugs can result in transgenerational genomic instability in mice.

6. A novel link to base excision repair?

7. SOS regulation of the type III secretion system of enteropathogenic Escherichia coli.

8. Role of the Streptococcus mutans CRISPR-Cas systems in immunity and cell physiology.

9. Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery.

10. KSR1 is required for cell cycle reinitiation following DNA damage.