Literature DB >> 15602548

Lessons from natural molecules.

Jon Clardy1, Christopher Walsh.   

Abstract

Natural products have inspired chemists and physicians for millennia. Their rich structural diversity and complexity has prompted synthetic chemists to produce them in the laboratory, often with therapeutic applications in mind, and many drugs used today are natural products or natural-product derivatives. Recent years have seen considerable advances in our understanding of natural-product biosynthesis. Coupled with improvements in approaches for natural-product isolation, characterization and synthesis, these could be opening the door to a new era in the investigation of natural products in academia and industry.

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Year:  2004        PMID: 15602548     DOI: 10.1038/nature03194

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  226 in total

1.  Bivalent ligand containing curcumin and cholesterol as fluorescence probe for Aβ plaques in Alzheimer's disease.

Authors:  Kai Liu; Tai L Guo; Jeremy Chojnacki; Hyoung-Gon Lee; Xinglong Wang; Sandra L Siedlak; Wei Rao; Xiongwei Zhu; Shijun Zhang
Journal:  ACS Chem Neurosci       Date:  2011-12-11       Impact factor: 4.418

2.  Biosynthesis: not just passing through.

Authors:  Jason M Crawford; Jon Clardy
Journal:  Nat Chem       Date:  2010-10       Impact factor: 24.427

Review 3.  Natural products as chemical probes.

Authors:  Erin E Carlson
Journal:  ACS Chem Biol       Date:  2010-07-16       Impact factor: 5.100

4.  Size Does Matter: Application-driven Approaches for Soil Metagenomics.

Authors:  Kavita S Kakirde; Larissa C Parsley; Mark R Liles
Journal:  Soil Biol Biochem       Date:  2010-11-01       Impact factor: 7.609

5.  Chemical Control in the Battle against Fidelity in Promiscuous Natural Product Biosynthesis: The Case of Trichodiene Synthase.

Authors:  Mudit Dixit; Michal Weitman; Jiali Gao; Dan T Major
Journal:  ACS Catal       Date:  2016-12-02       Impact factor: 13.084

6.  Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses.

Authors:  Jennifer Lee; Pedro M Moraes-Vieira; Angela Castoldi; Pratik Aryal; Eric U Yee; Christopher Vickers; Oren Parnas; Cynthia J Donaldson; Alan Saghatelian; Barbara B Kahn
Journal:  J Biol Chem       Date:  2016-08-29       Impact factor: 5.157

7.  Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization.

Authors:  Joseph M Langenhan; Noël R Peters; Ilia A Guzei; F Michael Hoffmann; Jon S Thorson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-16       Impact factor: 11.205

8.  Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection.

Authors:  Brian N Tse; Thomas M Snyder; Yinghua Shen; David R Liu
Journal:  J Am Chem Soc       Date:  2008-10-29       Impact factor: 15.419

9.  Isolation and structure determination of a proteasome inhibitory metabolite from a culture of Scytonema hofmanni.

Authors:  Sang Hee Shim; George Chlipala; Jimmy Orjala
Journal:  J Microbiol Biotechnol       Date:  2008-10       Impact factor: 2.351

10.  Synthetic libraries of tyrosine-derived bacterial metabolites.

Authors:  Savvas N Georgiades; Jon Clardy
Journal:  Bioorg Med Chem Lett       Date:  2007-10-22       Impact factor: 2.823

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