OBJECTIVES: To analyse 80-kVp 16-MDCT in patients with clinically suspected pulmonary embolism (PE) and diminished renal function after a reduction in dose of contrast medium (CM) from 200 to 150 mg I/kg. METHODS: Fifty patients with suspected PE and glomerular filtration rate (GFR) less than 50 mL/min underwent 80-kVp 16-MDCT with 150 mg I/kg. Mean density/image noise (1 standard deviation) was measured in a region of interest in the left pulmonary artery (LPA) and a lower lobe segmental artery (LLSA), and the contrast-to-noise ratio (CNR) was calculated. The values of LPA and LLSA were averaged. RESULTS: Median values/2.5-97.5 percentiles were: age 84/67-96 years, weight 65/43-84 kg, GFR 36/21-45 mL/min, CM dose 9.6/6.4-12 g of iodine, PA density 353/164-495 HU and CNR 11/4.4-20. PE incidence was 16%, and 8% and 12% of the examinations were regarded suboptimal by observer 1 and 2, respectively. Density/CNR values were within ranges reported for common 120-kVp MDCT protocols. None of 32 patients with plasma-creatinine follow-up within 1 week experienced a rise of more than 44.2 mumol/L and none of 50 patients had oliguria/anuria or dialysis. None of 40 patients with a negative CT/no anticoagulation had thromboembolism during follow-up. CONCLUSION: 80-kVp MDCT combined with individualised ultralow CM doses may provide satisfactory diagnostic quality, which should be to the benefit of patients at risk of contrast medium-induced nephropathy.
OBJECTIVES: To analyse 80-kVp 16-MDCT in patients with clinically suspected pulmonary embolism (PE) and diminished renal function after a reduction in dose of contrast medium (CM) from 200 to 150 mg I/kg. METHODS: Fifty patients with suspected PE and glomerular filtration rate (GFR) less than 50 mL/min underwent 80-kVp 16-MDCT with 150 mg I/kg. Mean density/image noise (1 standard deviation) was measured in a region of interest in the left pulmonary artery (LPA) and a lower lobe segmental artery (LLSA), and the contrast-to-noise ratio (CNR) was calculated. The values of LPA and LLSA were averaged. RESULTS: Median values/2.5-97.5 percentiles were: age 84/67-96 years, weight 65/43-84 kg, GFR 36/21-45 mL/min, CM dose 9.6/6.4-12 g of iodine, PA density 353/164-495 HU and CNR 11/4.4-20. PE incidence was 16%, and 8% and 12% of the examinations were regarded suboptimal by observer 1 and 2, respectively. Density/CNR values were within ranges reported for common 120-kVp MDCT protocols. None of 32 patients with plasma-creatinine follow-up within 1 week experienced a rise of more than 44.2 mumol/L and none of 50 patients had oliguria/anuria or dialysis. None of 40 patients with a negative CT/no anticoagulation had thromboembolism during follow-up. CONCLUSION: 80-kVp MDCT combined with individualised ultralow CM doses may provide satisfactory diagnostic quality, which should be to the benefit of patients at risk of contrast medium-induced nephropathy.
Authors: Matthew J Kuhn; Nan Chen; Dushyant V Sahani; Dan Reimer; Edwin J R van Beek; Jay P Heiken; George J So Journal: AJR Am J Roentgenol Date: 2008-07 Impact factor: 3.959
Authors: H Dirk Sostman; Paul D Stein; Alexander Gottschalk; Fadi Matta; Russell Hull; Larry Goodman Journal: Radiology Date: 2008-01-14 Impact factor: 11.105
Authors: Babs M F Hendriks; Madeleine Kok; Casper Mihl; Sebastiaan C A M Bekkers; Joachim E Wildberger; Marco Das Journal: Br J Radiol Date: 2016-01-22 Impact factor: 3.039
Authors: Tobias De Zordo; Klemens von Lutterotti; Christian Dejaco; Peter F Soegner; Renate Frank; Friedrich Aigner; Andrea S Klauser; Christoph Pechlaner; U Joseph Schoepf; Werner R Jaschke; Gudrun M Feuchtner Journal: Eur Radiol Date: 2011-08-28 Impact factor: 5.315
Authors: Zsolt Szucs-Farkas; Boglarka Megyeri; Andreas Christe; Peter Vock; Johannes T Heverhagen; Sebastian T Schindera Journal: Eur Radiol Date: 2014-05-28 Impact factor: 5.315
Authors: Nicolas Mansencal; David Attias; Vincent Caille; Julien Desperramons; Julie Guiader; Mostafa El Hajjam; Pascal Lacombe; Imad Abi Nasr; François Jardin; Antoine Vieillard-Baron; Olivier Dubourg Journal: Eur Radiol Date: 2010-08-31 Impact factor: 5.315
Authors: Li Xiu Cao; Huan Zhang; Bo Liu; Wen Jie Yang; Yan Yan Zhang; Zi Lai Pan; Fu Hua Yan; Ke Min Chen Journal: Int J Cardiovasc Imaging Date: 2013-05-05 Impact factor: 2.357