PURPOSE: To verify the usefulness of our developed beam ON-LINE positron emission tomography (PET) system mounted on a rotating gantry port (BOLPs-RGp) for dose-volume delivery-guided proton therapy (DGPT). METHODS AND MATERIALS: In the proton treatment room at our facility, a BOLPs-RGp was constructed so that a planar PET apparatus could be mounted with its field of view covering the iso-center of the beam irradiation system. Activity measurements were performed in 48 patients with tumors of the head and neck, liver, lungs, prostate, and brain. The position and intensity of the activity were measured using the BOLPs-RGp during the 200 s immediately after the proton irradiation. RESULTS: The daily measured activity images acquired by the BOLPs-RGp showed the proton irradiation volume in each patient. Changes in the proton-irradiated volume were indicated by differences between a reference activity image (taken at the first treatment) and the daily activity-images. In the case of head-and-neck treatment, the activity distribution changed in the areas where partial tumor reduction was observed. In the case of liver treatment, it was observed that the washout effect in necrotic tumor cells was slower than in non-necrotic tumor cells. CONCLUSIONS: The BOLPs-RGp was developed for the DGPT. The accuracy of proton treatment was evaluated by measuring changes of daily measured activity. Information about the positron-emitting nuclei generated during proton irradiation can be used as a basis for ensuring the high accuracy of irradiation in proton treatment.
PURPOSE: To verify the usefulness of our developed beam ON-LINE positron emission tomography (PET) system mounted on a rotating gantry port (BOLPs-RGp) for dose-volume delivery-guided proton therapy (DGPT). METHODS AND MATERIALS: In the proton treatment room at our facility, a BOLPs-RGp was constructed so that a planar PET apparatus could be mounted with its field of view covering the iso-center of the beam irradiation system. Activity measurements were performed in 48 patients with tumors of the head and neck, liver, lungs, prostate, and brain. The position and intensity of the activity were measured using the BOLPs-RGp during the 200 s immediately after the proton irradiation. RESULTS: The daily measured activity images acquired by the BOLPs-RGp showed the proton irradiation volume in each patient. Changes in the proton-irradiated volume were indicated by differences between a reference activity image (taken at the first treatment) and the daily activity-images. In the case of head-and-neck treatment, the activity distribution changed in the areas where partial tumor reduction was observed. In the case of liver treatment, it was observed that the washout effect in necrotic tumor cells was slower than in non-necrotic tumor cells. CONCLUSIONS: The BOLPs-RGp was developed for the DGPT. The accuracy of proton treatment was evaluated by measuring changes of daily measured activity. Information about the positron-emitting nuclei generated during proton irradiation can be used as a basis for ensuring the high accuracy of irradiation in proton treatment.
Authors: Maria Giuseppina Bisogni; Andrea Attili; Giuseppe Battistoni; Nicola Belcari; Niccolo' Camarlinghi; Piergiorgio Cerello; Silvia Coli; Alberto Del Guerra; Alfredo Ferrari; Veronica Ferrero; Elisa Fiorina; Giuseppe Giraudo; Eleftheria Kostara; Matteo Morrocchi; Francesco Pennazio; Cristiana Peroni; Maria Antonietta Piliero; Giovanni Pirrone; Angelo Rivetti; Manuel D Rolo; Valeria Rosso; Paola Sala; Giancarlo Sportelli; Richard Wheadon Journal: J Med Imaging (Bellingham) Date: 2016-12-02
Authors: Xuping Zhu; Samuel España; Juliane Daartz; Norbert Liebsch; Jinsong Ouyang; Harald Paganetti; Thomas R Bortfeld; Georges El Fakhri Journal: Phys Med Biol Date: 2011-06-15 Impact factor: 3.609
Authors: Kira Grogg; Xuping Zhu; Chul Hee Min; Brian Winey; Thomas Bortfeld; Harald Paganetti; Helen A Shih; Georges El Fakhri Journal: IEEE Trans Nucl Sci Date: 2013-10 Impact factor: 1.679