A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.
A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named n class="Chemical">hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBCNMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435melanoma, and U937lymphoma cancer cell lines.
Authors: Tyler A Johnson; Johann Sohn; Wayne D Inman; Samarkand A Estee; Steven T Loveridge; Helene C Vervoort; Karen Tenney; Junke Liu; Kenny Kean-Hooi Ang; Joseline Ratnam; Walter M Bray; Nadine C Gassner; Young Y Shen; R Scott Lokey; James H McKerrow; Kyria Boundy-Mills; Arif Nukanto; Atit Kanti; Heddy Julistiono; Leonardus B S Kardono; Leonard F Bjeldanes; Phillip Crews Journal: J Nat Prod Date: 2011-11-30 Impact factor: 4.050