Literature DB >> 20000782

A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.

Wayne D Inman1, Walter M Bray, Nadine C Gassner, R Scott Lokey, Karen Tenney, Young Yongchun Shen, Karen Tendyke, Ted Suh, Phillip Crews.   

Abstract

A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.

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Year:  2010        PMID： 20000782      PMCID： PMC2829331          DOI： 10.1021/np9005426

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  15 in total

1.  Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata.

Authors:  N Alam; B H Bae; J Hong; C O Lee; B A Shin; K S Im; J H Jung
Journal:  J Nat Prod       Date:  2001-04       Impact factor: 4.050

2.  Hyrtioerectines A-C, cytotoxic alkaloids from the red sea sponge hyrtioserectus.

Authors:  Diaa T A Youssef
Journal:  J Nat Prod       Date:  2005-09       Impact factor: 4.050

3.  Puupehenone, a cytotoxic metabolite from a deep water marine sponge, Stronglyophora hartmani.

Authors:  S Kohmoto; O J McConnell; A Wright; F Koehn; W Thompson; M Lui; K M Snader
Journal:  J Nat Prod       Date:  1987 Mar-Apr       Impact factor: 4.050

4.  Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

Authors:  C Braestrup; M Nielsen; C E Olsen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-04       Impact factor: 11.205

Review 5.  Long-range (1)H-(15)N heteronuclear shift correlation at natural abundance.

Authors:  G E Martin; C E Hadden
Journal:  J Nat Prod       Date:  2000-04       Impact factor: 4.050

6.  Isolation and identification in bovine cerebral cortex of n-butyl beta-carboline-3-carboxylate, a potent benzodiazepine binding inhibitor.

Authors:  C Peña; J H Medina; M L Novas; A C Paladini; E De Robertis
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

7.  Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.

Authors:  George R Pettit; Rui Tan; Zbigniew A Cichacz
Journal:  J Nat Prod       Date:  2005-08       Impact factor: 4.050

8.  New beta-carboline alkaloids from the Andaman Sea sponge Dragmacidon sp.

Authors:  Suwigarn Pedpradab; RuAngelie Edrada; Rainer Ebel; Victor Wray; Peter Proksch
Journal:  J Nat Prod       Date:  2004-12       Impact factor: 4.050

9.  New structures and bioactivity patterns of bengazole alkaloids from a choristid marine sponge.

Authors:  J Rodríguez; R M Nieto; P Crews
Journal:  J Nat Prod       Date:  1993-12       Impact factor: 4.050

10.  5-hydroxytryptamine-derived alkaloids from two marine sponges of the genus Hyrtios.

Authors:  Mostafa Salmoun; Christine Devijver; Désiré Daloze; Jean-Claude Braekman; Rob W M van Soest
Journal:  J Nat Prod       Date:  2002-08       Impact factor: 4.050
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  9 in total

1.  Rh(II)2-catalyzed synthesis of α-, β-, or δ-carbolines from aryl azides.

Authors:  Ashley L Pumphrey; Huijun Dong; Tom G Driver
Journal:  Angew Chem Int Ed Engl       Date:  2012-04-26       Impact factor: 15.336

2.  Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.

Authors:  Tyler A Johnson; Johann Sohn; Wayne D Inman; Samarkand A Estee; Steven T Loveridge; Helene C Vervoort; Karen Tenney; Junke Liu; Kenny Kean-Hooi Ang; Joseline Ratnam; Walter M Bray; Nadine C Gassner; Young Y Shen; R Scott Lokey; James H McKerrow; Kyria Boundy-Mills; Arif Nukanto; Atit Kanti; Heddy Julistiono; Leonardus B S Kardono; Leonard F Bjeldanes; Phillip Crews
Journal:  J Nat Prod       Date:  2011-11-30       Impact factor: 4.050

Review 3.  Synthesis of indole derivatives as prevalent moieties present in selected alkaloids.

Authors:  Majid M Heravi; Zahra Amiri; Kosar Kafshdarzadeh; Vahideh Zadsirjan
Journal:  RSC Adv       Date:  2021-10-15       Impact factor: 4.036

4.  A β-carboline derivative-based nickel(ii) complex as a potential antitumor agent: synthesis, characterization, and cytotoxicity.

Authors:  Jing-Mei Yang; Yan-Hong Zhu; Sheng Chen; Xing Lu; Yi-Ming Wu; Feng-E Ma; Liang-Ping Li; Yang Yang; Zhen-Hao Shi; Kun-Yuan Huang; Xue Hong; Ping Jiang; Yan Peng
Journal:  Medchemcomm       Date:  2017-11-24       Impact factor: 3.597

5.  Cu-catalyzed mild and efficient oxidation of THβCs using air: application in practical total syntheses of perlolyrine and flazin.

Authors:  Bo Zheng; Tien Ha Trieu; Tian-Zhuo Meng; Xia Lu; Jing Dong; Qiang Zhang; Xiao-Xin Shi
Journal:  RSC Adv       Date:  2018-02-12       Impact factor: 4.036

Review 6.  Cytotoxic Compounds Derived from Marine Sponges. A Review (2010-2012).

Authors:  Roberto Mioso; Francisco J Toledo Marante; Ranilson de Souza Bezerra; Flávio Valadares Pereira Borges; Bárbara V de Oliveira Santos; Irma Herrera Bravo de Laguna
Journal:  Molecules       Date:  2017-01-28       Impact factor: 4.411

Review 7.  A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2010.

Authors:  Marc Schumacher; Mareike Kelkel; Mario Dicato; Marc Diederich
Journal:  Molecules       Date:  2011-06-30       Impact factor: 4.411

Review 8.  Bioactive Natural Products of Marine Sponges from the Genus Hyrtios.

Authors:  Nourhan Hisham Shady; Ebaa M El-Hossary; Mostafa A Fouad; Tobias A M Gulder; Mohamed Salah Kamel; Usama Ramadan Abdelmohsen
Journal:  Molecules       Date:  2017-05-11       Impact factor: 4.411

Review 9.  Marine Indole Alkaloids.

Authors:  Natalie Netz; Till Opatz
Journal:  Mar Drugs       Date:  2015-08-06       Impact factor: 5.118
  9 in total

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