Literature DB >> 16124771

Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta.

George R Pettit1, Rui Tan, Zbigniew A Cichacz.   

Abstract

A new scalarane-type pentacyclic sesterterpene, sesterstatin 6 (6), was isolated in 8.3 x 10(-7)% yield from the Republic of Maldives marine sponge Hyrtios erecta. The structure was elucidated by analyses of HRMS and high-field 2-D NMR spectra. Sesterstatin 6 showed significant cancer cell growth inhibition against murine P388 lymphocytic leukemia and a series of human tumor cell lines (ED50 0.17 microg/mL, GI50 1.8-8.9 x 10(-1) microg/mL) and proved to be the most inhibitory of the series.

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Year:  2005        PMID： 16124771      PMCID： PMC3335338          DOI： 10.1021/np0402221

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  11 in total

1.  Theopederins K and L. Highly potent cytotoxic metabolites from a marine sponge Discodermia species.

Authors:  Gopal K Paul; Sarath P Gunasekera; Ross E Longley; Shirley A Pomponi
Journal:  J Nat Prod       Date:  2002-01       Impact factor: 4.050

2.  Antineoplastic agents. 386. Isolation of sesterstatins 1-3 from the marine sponge Hyrtios erecta.

Authors:  G R Pettit; A Cichacz; R Tan; M S Hoard; N Melody; R Pettit
Journal:  J Nat Prod       Date:  1998-01       Impact factor: 4.050

3.  Isolation and structure of phakellistatin 14 from the Western Pacific marine sponge Phakellia sp.

Authors:  George R Pettit; Rui Tan
Journal:  J Nat Prod       Date:  2005-01       Impact factor: 4.050

4.  Three new scalarane sesterterpenoids from the Okinawan sponge Hyrtios erectus.

Authors:  H Miyaoka; S Nishijima; H Mitome; Y Yamada
Journal:  J Nat Prod       Date:  2000-10       Impact factor: 4.050

5.  Thorectandrols C, D, and E, new sesterterpenes from the marine sponge Thorectandra sp.

Authors:  Romila D Charan; Tawnya C McKee; Michael R Boyd
Journal:  J Nat Prod       Date:  2002-04       Impact factor: 4.050

6.  New biologically active marine sesquiterpenoid and steroid from the okinawan sponge of the genus Axinyssa.

Authors:  Makoto Iwashima; Ikuo Terada; Kazuo Iguchi; Takao Yamori
Journal:  Chem Pharm Bull (Tokyo)       Date:  2002-09       Impact factor: 1.645

7.  Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).

Authors:  G R Pettit; R Tan; N Melody; Z A Cichacz; D L Herald; M S Hoard; R K Pettit; J C Chapuis
Journal:  Bioorg Med Chem Lett       Date:  1998-08-18       Impact factor: 2.823

8.  Yardenone A and B: new cytotoxic triterpenes from the Indian Ocean sponge Axinella cf. bidderi.

Authors:  Isabelle Carletti; Christophe Long; Corinne Funel; Philippe Amade
Journal:  J Nat Prod       Date:  2003-01       Impact factor: 4.050

9.  Cytotoxic pyrrolo- and furanoterpenoids from the sponge sarcotragus species.

Authors:  Yonghong Liu; Jongki Hong; Chong-O Lee; Kwang Sik Im; Nam Deuk Kim; Jae Sue Choi; Jee H Jung
Journal:  J Nat Prod       Date:  2002-09       Impact factor: 4.050

10.  Sesterterpenoids from the marine sponge Hyrtios erectus.

Authors:  Yan Qiu; Zhiwei Deng; Yuehu Pei; Hongzheng Fu; Jun Li; Peter Proksch; Wenhan Lin
Journal:  J Nat Prod       Date:  2004-05       Impact factor: 4.050
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  10 in total

1.  A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.

Authors:  Wayne D Inman; Walter M Bray; Nadine C Gassner; R Scott Lokey; Karen Tenney; Young Yongchun Shen; Karen Tendyke; Ted Suh; Phillip Crews
Journal:  J Nat Prod       Date:  2010-02-26       Impact factor: 4.050

Review 2.  Marine pharmacology in 2005-2006: antitumour and cytotoxic compounds.

Authors:  Alejandro M S Mayer; Kirk R Gustafson
Journal:  Eur J Cancer       Date:  2008-08-11       Impact factor: 9.162

Review 3.  Targeting cancer with sesterterpenoids: the new potential antitumor drugs.

Authors:  Caiguo Zhang; Yan Liu
Journal:  J Nat Med       Date:  2015-04-19       Impact factor: 2.343

4.  Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus.

Authors:  Sameh S Elhady; Ahmed M Al-Abd; Ali M El-Halawany; Abdulrahman M Alahdal; Hashim A Hassanean; Safwat A Ahmed
Journal:  Mar Drugs       Date:  2016-07-08       Impact factor: 5.118

Review 5.  Bioactive Natural Products of Marine Sponges from the Genus Hyrtios.

Authors:  Nourhan Hisham Shady; Ebaa M El-Hossary; Mostafa A Fouad; Tobias A M Gulder; Mohamed Salah Kamel; Usama Ramadan Abdelmohsen
Journal:  Molecules       Date:  2017-05-11       Impact factor: 4.411

6.  Cheiradone: a vascular endothelial cell growth factor receptor antagonist.

Authors:  Sajjad Hussain; Mark Slevin; Mohammad A Mesaik; Mohammad I Choudhary; Abdul H Elosta; Sabine Matou; Nessar Ahmed; David West; John Gaffney
Journal:  BMC Cell Biol       Date:  2008-01-29       Impact factor: 4.241

7.  Bioactive compounds from the Red Sea marine sponge Hyrtios species.

Authors:  Diaa T A Youssef; Lamiaa A Shaala; Hani Z Asfour
Journal:  Mar Drugs       Date:  2013-03-28       Impact factor: 5.118

8.  Anti-Helicobacter, Antitubercular and Cytotoxic Activities of Scalaranes from the Red Sea Sponge Hyrtios erectus.

Authors:  Abdulrahman M Alahdal; Hani Z Asfour; Safwat A Ahmed; Ahmad O Noor; Ahmed M Al-Abd; Mahmoud A Elfaky; Sameh S Elhady
Journal:  Molecules       Date:  2018-04-23       Impact factor: 4.411

9.  Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus.

Authors:  Oh-Seok Kwon; Donghwa Kim; Chang-Kwon Kim; Jeongyoon Sun; Chung J Sim; Dong-Chan Oh; Sang Koo Lee; Ki-Bong Oh; Jongheon Shin
Journal:  Mar Drugs       Date:  2020-05-13       Impact factor: 5.118

10.  Molecular Docking and Dynamics Simulation Study of Hyrtios erectus Isolated Scalarane Sesterterpenes as Potential SARS-CoV-2 Dual Target Inhibitors.

Authors:  Sameh S Elhady; Reda F A Abdelhameed; Rania T Malatani; Abdulrahman M Alahdal; Hanin A Bogari; Ahmad J Almalki; Khadijah A Mohammad; Safwat A Ahmed; Amgad I M Khedr; Khaled M Darwish
Journal:  Biology (Basel)       Date:  2021-05-01
  10 in total

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