Literature DB >> 19874044

Bioactive constituents of the stem bark of Mitrephora glabra.

Chen Li1, Dongho Lee, Tyler N Graf, Sharnelle S Phifer, Yuka Nakanishi, Soedarsono Riswan, Fransisca M Setyowati, Achmad M Saribi, Djaja D Soejarto, Norman R Farnsworth, Joseph O Falkinham, David J Kroll, A Douglas Kinghorn, Mansukh C Wani, Nicholas H Oberlies.   

Abstract

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.

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Year:  2009        PMID： 19874044      PMCID： PMC2862477          DOI： 10.1021/np900572g

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  15 in total

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3.  A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.

Authors:  Chen Li; Dongho Lee; Tyler N Graf; Sharnelle S Phifer; Yuka Nakanishi; Jason P Burgess; Soedarsono Riswan; Fransisca M Setyowati; Achmad M Saribi; Djaja D Soejarto; Norman R Farnsworth; Joseph O Falkinham; David J Kroll; A Douglas Kinghorn; Mansukh C Wani; Nicholas H Oberlies
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Journal:  Phytomedicine       Date:  1996-11       Impact factor: 5.340

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Journal:  Nat Prod Res       Date:  2005-06       Impact factor: 2.861

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Journal:  J Nat Prod       Date:  1994-01       Impact factor: 4.050
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