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Literature DB >> 10096871

Annonaceous acetogenins: recent progress.

Abstract

The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995.

Entities: Chemical Disease Gene

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Year: 1999 PMID： 10096871 DOI： 10.1021/np980406d

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

73 in total

1. Palladium-catalyzed synthesis of 2,1'-disubstituted tetrahydrofurans from gamma-hydroxy internal alkenes. Evidence for alkene insertion into a Pd-O bond and stereochemical scrambling via beta-hydride elimination.

Authors: Michael B Hay; John P Wolfe
Journal: J Am Chem Soc Date: 2005-11-30 Impact factor: 15.419

2. Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane.

Authors: Jennifer M Tinsley; Eric Mertz; Pek Y Chong; Robert-André F Rarig; William R Roush
Journal: Org Lett Date: 2005-09-15 Impact factor: 6.005

3. Total synthesis of (-)-mucocin.

Authors: Michael T Crimmins; Yan Zhang; Frank A Diaz
Journal: Org Lett Date: 2006-05-25 Impact factor: 6.005

4. Acute and Chronic Toxicities of an Annonin-Based Commercial Bioinsecticide and a Joint Mixture with a Limonoid-Based Formulation to the Fall Armyworm.

Authors: T F Ansante; L P Ribeiro; J D Vendramim
Journal: Neotrop Entomol Date: 2016-10-12 Impact factor: 1.434

5. In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants.

Authors: Eugénie Aimée Madiesse Kemgne; Wilfred Fon Mbacham; Fabrice Fekam Boyom; Paul Henri Amvam Zollo; Etienne Tsamo; Philip J Rosenthal
Journal: Parasitol Res Date: 2011-07-08 Impact factor: 2.289

6. Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I.

Authors: Nuria de Pedro; Bastien Cautain; Angeles Melguizo; Diego Cortes; Francisca Vicente; Olga Genilloud; Jose R Tormo; Fernando Peláez
Journal: J Bioenerg Biomembr Date: 2012-11-21 Impact factor: 2.945

Annonaceous acetogenins: recent progress.

1. Palladium-catalyzed synthesis of 2,1'-disubstituted tetrahydrofurans from gamma-hydroxy internal alkenes. Evidence for alkene insertion into a Pd-O bond and stereochemical scrambling via beta-hydride elimination.

2. Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane.

3. Total synthesis of (-)-mucocin.

4. Acute and Chronic Toxicities of an Annonin-Based Commercial Bioinsecticide and a Joint Mixture with a Limonoid-Based Formulation to the Fall Armyworm.

5. In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants.

6. Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I.

7. Synthesis and anti-tumor activity of carbohydrate analogues of the tetrahydrofuran containing acetogenins.

8. Synthesis of polysubstituted tetrahydrofurans via Pd-catalyzed carboetherification reactions.

9. Recent progress on the total synthesis of acetogenins from Annonaceae.

10. Oxidative cyclization of alkenols with oxone using a miniflow reactor.