| Literature DB >> 23195084 |
M E Wall1, M C Wani, D M Brown, F Fullas, J B Olwald, F F Josephson, N M Thornton, J M Pezzuto, C W Beecher, N R Farnsworth, G A Cordell, A D Kinghorn.
Abstract
Ethyl acetate and aqueous extracts of tannin-containing topoisomerase inhibitory plant samples were subjected to one or more of seven tannin removal procedures, and the resulting products were subsequently evaluated for topoisomerase inhibitory activity. In most of the samples investigated, the initial activity was lost after tannin removal. It was concluded that the activity initially observed was primarily due to tannins. Procedures are presented for routinely obtaining tannin-free organic and aqueous fractions.Entities:
Year: 1996 PMID： 23195084 DOI： 10.1016/S0944-7113(96)80067-5
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340