Literature DB >> 12165345

Antimicrobial diterpenes from the stem bark of Mitrephora celebica.

J R Zgoda-Pols1, A J Freyer, L B Killmer, J R Porter.   

Abstract

Four diterpenes were isolated from the stem bark of Mitrephora celebica through bioassay-guided fractionation. Ent-trachyloban-19-oic acid (1) and ent-kaur-16-en-19-oic acid (2) were identified as the compounds responsible for the antimicrobial activity of the plant against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis. 8(14),15-pimaradien-18-oic acid (3) and 7,15-pimaradien-18-oic acid (4) were isolated from the same fraction and were inactive against the microorganisms.

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Year:  2002        PMID： 12165345     DOI： 10.1016/s0367-326x(02)00124-7

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  5 in total

1.  A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.

Authors:  Chen Li; Dongho Lee; Tyler N Graf; Sharnelle S Phifer; Yuka Nakanishi; Jason P Burgess; Soedarsono Riswan; Fransisca M Setyowati; Achmad M Saribi; Djaja D Soejarto; Norman R Farnsworth; Joseph O Falkinham; David J Kroll; A Douglas Kinghorn; Mansukh C Wani; Nicholas H Oberlies
Journal:  Org Lett       Date:  2005-12-08       Impact factor: 6.005

Review 2.  Occurrence, biological activities and synthesis of kaurane diterpenes and their glycosides.

Authors:  Pablo Anselmo García; Alaíde Braga de Oliveira; Ronan Batista
Journal:  Molecules       Date:  2007-03-13       Impact factor: 4.411

3.  Bioactive constituents of the stem bark of Mitrephora glabra.

Authors:  Chen Li; Dongho Lee; Tyler N Graf; Sharnelle S Phifer; Yuka Nakanishi; Soedarsono Riswan; Fransisca M Setyowati; Achmad M Saribi; Djaja D Soejarto; Norman R Farnsworth; Joseph O Falkinham; David J Kroll; A Douglas Kinghorn; Mansukh C Wani; Nicholas H Oberlies
Journal:  J Nat Prod       Date:  2009-11       Impact factor: 4.050

4.  Cytotoxic compounds from the leaves and stems of the endemic Thai plant Mitrephora sirikitiae.

Authors:  Natthinee Anantachoke; Duangporn Lovacharaporn; Vichai Reutrakul; Sylvie Michel; Thomas Gaslonde; Pawinee Piyachaturawat; Kanoknetr Suksen; Samran Prabpai; Narong Nuntasaen
Journal:  Pharm Biol       Date:  2020-12       Impact factor: 3.503

5.  Total Synthesis of (-)-Mitrephorone A Enabled by Stereoselective Nitrile Oxide Cycloaddition and Tetrasubstituted Olefin Synthesis.

Authors:  Michael Schneider; Matthieu J R Richter; Erick M Carreira
Journal:  J Am Chem Soc       Date:  2020-10-06       Impact factor: 15.419
  5 in total

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