| Literature DB >> 19850077 |
Rachael D Seidler1, Jessica A Bernard, Taritonye B Burutolu, Brett W Fling, Mark T Gordon, Joseph T Gwin, Youngbin Kwak, David B Lipps.
Abstract
Although connections between cognitive deficits and age-associated brain differences have been elucidated, relationships with motor performance are less well understood. Here, we broadly review age-related brain differences and motor deficits in older adults in addition to cognition-action theories. Age-related atrophy of the motor cortical regions and corpus callosum may precipitate or coincide with motor declines such as balance and gait deficits, coordination deficits, and movement slowing. Correspondingly, degeneration of neurotransmitter systems-primarily the dopaminergic system-may contribute to age-related gross and fine motor declines, as well as to higher cognitive deficits. In general, older adults exhibit involvement of more widespread brain regions for motor control than young adults, particularly the prefrontal cortex and basal ganglia networks. Unfortunately these same regions are the most vulnerable to age-related effects, resulting in an imbalance of "supply and demand". Existing exercise, pharmaceutical, and motor training interventions may ameliorate motor deficits in older adults. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Year: 2009 PMID： 19850077 PMCID： PMC2838968 DOI： 10.1016/j.neubiorev.2009.10.005
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989