| Literature DB >> 24559659 |
Janna L Harris1, Hung-Wen Yeh2, Russell H Swerdlow3, In-Young Choi4, Phil Lee5, William M Brooks4.
Abstract
Altered brain metabolism is likely to be an important contributor to normal cognitive decline and brain pathology in elderly individuals. To characterize the metabolic changes associated with normal brain aging, we used high-field proton magnetic resonance spectroscopy in vivo to quantify 20 neurochemicals in the hippocampus and sensorimotor cortex of young adult and aged rats. We found significant differences in the neurochemical profile of the aged brain when compared with younger adults, including lower aspartate, ascorbate, glutamate, and macromolecules, and higher glucose, myo-inositol, N-acetylaspartylglutamate, total choline, and glutamine. These neurochemical biomarkers point to specific cellular mechanisms that are altered in brain aging, such as bioenergetics, oxidative stress, inflammation, cell membrane turnover, and endogenous neuroprotection. Proton magnetic resonance spectroscopy may be a valuable translational approach for studying mechanisms of brain aging and pathology, and for investigating treatments to preserve or enhance cognitive function in aging.Entities:
Keywords: Aging; Bioenergetics; Biomarker; Inflammation; In vivo; Magnetic resonance imaging; Membrane turnover; Neurochemical profile; Oxidative stress; Proton magnetic resonance spectroscopy
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Year: 2014 PMID： 24559659 PMCID： PMC4174428 DOI： 10.1016/j.neurobiolaging.2014.01.018
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673