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Literature DB >> 19837595

Synthesis of bis-Schiff bases of isatins and their antiglycation activity.

Khalid Mohammed Khan¹, Momin Khan, Muhammad Ali, Muhammad Taha, Saima Rasheed, Shahnaz Perveen, M Iqbal Choudhary.

Abstract

Bis-Schiff bases 1-27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC(50)=243.95+/-4.59microM), 20 (IC(50)=257.61+/-5.63microM), and 7 (IC(50)=291.14+/-2.53microM) showed an excellent antiglycation activity better than the standard (rutin, IC(50)=294.46+/-1.50microM). This study has identified a series of potential molecules as antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19837595 DOI： 10.1016/j.bmc.2009.09.028

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

20 in total

1. QM study and conformational analysis of an isatin Schiff base as a potential cytotoxic agent.

Authors: Ramin Miri; Nima Razzaghi-asl; Mohammad K Mohammadi
Journal: J Mol Model Date: 2012-09-29 Impact factor: 1.810

2. {2-[(3-Bromo-benzyl-idene)amino]-5-chloro-phen-yl}(phen-yl)methanone.

Authors: M Aslam; I Anis; N Afza; M Safder; S Yousuf
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2012-02-10

3. {5-Chloro-2-[(4-nitro-benzyl-idene)amino]-phen-yl}(phen-yl)methanone.

Authors: M Aslam; I Anis; N Afza; A Nelofar; S Yousuf
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2011-11-05

4. {5-Chloro-2-[(2-hy-droxy-benzyl-idene)amino]-phen-yl}(phen-yl)methanone.

Authors: M Aslam; I Anis; N Afza; A Nelofar; S Yousuf
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2011-11-25

5. Induction of anxiolytic, antidepressant and analgesic effects by Shiff base of (E)-3-(1H-imidazol-4-yl)-2-((2-oxoindolin-3-ylidene)amino)propanoic acid derivatives in diabetic rats.

Authors: Mohaddese Goleij; Leila Youseftabar-Miri; Maryam Montazeri; Fatemeh Khakpai
Journal: J Diabetes Metab Disord Date: 2021-01-03

Synthesis of bis-Schiff bases of isatins and their antiglycation activity.

1. QM study and conformational analysis of an isatin Schiff base as a potential cytotoxic agent.

2. {2-[(3-Bromo-benzyl-idene)amino]-5-chloro-phen-yl}(phen-yl)methanone.

3. {5-Chloro-2-[(4-nitro-benzyl-idene)amino]-phen-yl}(phen-yl)methanone.

4. {5-Chloro-2-[(2-hy-droxy-benzyl-idene)amino]-phen-yl}(phen-yl)methanone.

5. Induction of anxiolytic, antidepressant and analgesic effects by Shiff base of (E)-3-(1H-imidazol-4-yl)-2-((2-oxoindolin-3-ylidene)amino)propanoic acid derivatives in diabetic rats.

6. 2-[(E)-(Naphthalen-2-yl)imino-meth-yl]phenol.

7. (3,4-Dimeth-oxy-phen-yl)[2-(thio-phen-2-ylcarbon-yl)phen-yl]methanone.

8. 3-(2-Ethyl-2-phenyl-hydrazin-1-yl-idene)indolin-2-one.

9. N'-[(E)-2,3-Dihy-droxy-benzyl-idene]-2-meth-oxy-benzohydrazide.

10. 2-[(4-Bromo-benzyl-idene)amino]-ethanol.