Literature DB >> 19822728

Analysis of Ipl1-mediated phosphorylation of the Ndc80 kinetochore protein in Saccharomyces cerevisiae.

Bungo Akiyoshi1, Christian R Nelson, Jeffrey A Ranish, Sue Biggins.   

Abstract

Phosphorylation of the Ndc80 kinetochore protein by the Ipl1/Aurora B kinase reduces its microtubule binding activity in vitro. We found that kinetochore-bound Ndc80 is phosphorylated on Ipl1 sites in vivo, but this phosphorylation is not essential. Instead, we show that additional Ipl1 targets contribute to segregation and the spindle checkpoint.

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Year:  2009        PMID： 19822728      PMCID： PMC2787442          DOI： 10.1534/genetics.109.109041

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  21 in total

1.  The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.

Authors:  Benjamin A Pinsky; Charles Kung; Kevan M Shokat; Sue Biggins
Journal:  Nat Cell Biol       Date:  2005-12-04       Impact factor: 28.824

2.  S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function.

Authors:  M A Hoyt; L Totis; B T Roberts
Journal:  Cell       Date:  1991-08-09       Impact factor: 41.582

3.  Feedback control of mitosis in budding yeast.

Authors:  R Li; A W Murray
Journal:  Cell       Date:  1991-08-09       Impact factor: 41.582

4.  GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion.

Authors:  A F Straight; A S Belmont; C C Robinett; A W Murray
Journal:  Curr Biol       Date:  1996-12-01       Impact factor: 10.834

5.  Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p.

Authors:  Iain M Cheeseman; Scott Anderson; Miri Jwa; Erin M Green; Jung seog Kang; John R Yates; Clarence S M Chan; David G Drubin; Georjana Barnes
Journal:  Cell       Date:  2002-10-18       Impact factor: 41.582

6.  The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint.

Authors:  S Biggins; A W Murray
Journal:  Genes Dev       Date:  2001-12-01       Impact factor: 11.361

7.  The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast.

Authors:  S Biggins; F F Severin; N Bhalla; I Sassoon; A A Hyman; A W Murray
Journal:  Genes Dev       Date:  1999-03-01       Impact factor: 11.361

8.  Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.

Authors:  Tomoyuki U Tanaka; Najma Rachidi; Carsten Janke; Gislene Pereira; Marta Galova; Elmar Schiebel; Michael J R Stark; Kim Nasmyth
Journal:  Cell       Date:  2002-02-08       Impact factor: 41.582

9.  Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation.

Authors:  L Francisco; W Wang; C S Chan
Journal:  Mol Cell Biol       Date:  1994-07       Impact factor: 4.272

10.  The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly.

Authors:  Stéphanie Buvelot; Sean Y Tatsutani; Danielle Vermaak; Sue Biggins
Journal:  J Cell Biol       Date:  2003-02-03       Impact factor: 10.539
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  39 in total

Review 1.  Reconstituting the kinetochore–microtubule interface: what, why, and how.

Authors:  Bungo Akiyoshi; Sue Biggins
Journal:  Chromosoma       Date:  2012-06       Impact factor: 4.316

Review 2.  The composition, functions, and regulation of the budding yeast kinetochore.

Authors:  Sue Biggins
Journal:  Genetics       Date:  2013-08       Impact factor: 4.562

3.  Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface.

Authors:  Julie P I Welburn; Mathijs Vleugel; Dan Liu; John R Yates; Michael A Lampson; Tatsuo Fukagawa; Iain M Cheeseman
Journal:  Mol Cell       Date:  2010-05-14       Impact factor: 17.970

4.  Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit.

Authors:  Bungo Akiyoshi; Christian R Nelson; Jeffrey A Ranish; Sue Biggins
Journal:  Genes Dev       Date:  2009-12-15       Impact factor: 11.361

5.  Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis.

Authors:  Keith F DeLuca; Susanne M A Lens; Jennifer G DeLuca
Journal:  J Cell Sci       Date:  2011-01-25       Impact factor: 5.285

Review 6.  Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.

Authors:  Hironori Funabiki; David J Wynne
Journal:  Chromosoma       Date:  2013-03-20       Impact factor: 4.316

7.  Phosphoregulation promotes release of kinetochores from dynamic microtubules via multiple mechanisms.

Authors:  Krishna K Sarangapani; Bungo Akiyoshi; Nicole M Duggan; Sue Biggins; Charles L Asbury
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-15       Impact factor: 11.205

Review 8.  Catch and release: how do kinetochores hook the right microtubules during mitosis?

Authors:  Krishna K Sarangapani; Charles L Asbury
Journal:  Trends Genet       Date:  2014-03-13       Impact factor: 11.639

Review 9.  Protein kinases in mitotic phosphorylation of budding yeast CENP-A.

Authors:  Prashant K Mishra; Munira A Basrai
Journal:  Curr Genet       Date:  2019-05-22       Impact factor: 3.886

10.  Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B.

Authors:  Jerry F Tien; Neil T Umbreit; Daniel R Gestaut; Andrew D Franck; Jeremy Cooper; Linda Wordeman; Tamir Gonen; Charles L Asbury; Trisha N Davis
Journal:  J Cell Biol       Date:  2010-05-17       Impact factor: 10.539
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