Literature DB >> 19800226

Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation.

Jin Shi1, James S Stover, Landon R Whitby, Peter K Vogt, Dale L Boger.   

Abstract

The preparation and evaluation of a series of inhibitors of Myc/Max dimerization and Myc-induced cell transformation are described providing mycmycin-1 (3) and mycmycin-2 (4).

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Year:  2009        PMID： 19800226      PMCID： PMC2767179          DOI： 10.1016/j.bmcl.2009.09.044

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  47 in total

1.  Two comparisons of the performance of positional scanning and deletion synthesis for the identification of active constituents in mixture combinatorial libraries.

Authors:  D L Boger; J K Lee; J Goldberg; Q Jin
Journal:  J Org Chem       Date:  2000-03-10       Impact factor: 4.354

2.  Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3).

Authors:  D L Boger; J Goldberg; S Silletti; T Kessler; D A Cheresh
Journal:  J Am Chem Soc       Date:  2001-02-21       Impact factor: 15.419

Review 3.  Cytokine receptor dimerization and activation: prospects for small molecule agonists.

Authors:  D L Boger; J Goldberg
Journal:  Bioorg Med Chem       Date:  2001-03       Impact factor: 3.641

4.  X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors.

Authors:  Satish K Nair; Stephen K Burley
Journal:  Cell       Date:  2003-01-24       Impact factor: 41.582

5.  Discovery of inhibitors of aberrant gene transcription from Libraries of DNA binding molecules: inhibition of LEF-1-mediated gene transcription and oncogenic transformation.

Authors:  James S Stover; Jin Shi; Wei Jin; Peter K Vogt; Dale L Boger
Journal:  J Am Chem Soc       Date:  2009-03-11       Impact factor: 15.419

6.  Erythropoietin mimetics derived from solution phase combinatorial libraries.

Authors:  Joel Goldberg; Qing Jin; Yves Ambroise; Shigeki Satoh; Joel Desharnais; Kevin Capps; Dale L Boger
Journal:  J Am Chem Soc       Date:  2002-01-30       Impact factor: 15.419

Review 7.  The myc oncogene: MarvelouslY Complex.

Authors:  Sara K Oster; Cynthia S W Ho; Erinn L Soucie; Linda Z Penn
Journal:  Adv Cancer Res       Date:  2002       Impact factor: 6.242

8.  Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts.

Authors:  Thorsten Berg; Steven B Cohen; Joel Desharnais; Corinna Sonderegger; Daniel J Maslyar; Joel Goldberg; Dale L Boger; Peter K Vogt
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-12       Impact factor: 11.205

9.  Inhibitors of cell migration that inhibit intracellular paxillin/alpha4 binding: a well-documented use of positional scanning libraries.

Authors:  Yves Ambroise; Brian Yaspan; Mark H Ginsberg; Dale L Boger
Journal:  Chem Biol       Date:  2002-11

10.  Low molecular weight inhibitors of Myc-Max interaction and function.

Authors:  Xiaoying Yin; Christine Giap; John S Lazo; Edward V Prochownik
Journal:  Oncogene       Date:  2003-09-18       Impact factor: 9.867
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  31 in total

Review 1.  Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

Authors:  Roland E Dolle; Bertrand Le Bourdonnec; Karin Worm; Guillermo A Morales; Craig J Thomas; Wei Zhang
Journal:  J Comb Chem       Date:  2010-10-05

2.  Integrated analysis of transcription factor, microRNA and LncRNA in an animal model of obliterative bronchiolitis.

Authors:  Ming Dong; Xin Wang; Hong-Lin Zhao; Xing-Long Chen; Jing-Hua Yuan; Jiu-Yi Guo; Ke-Qiu Li; Guang Li
Journal:  Int J Clin Exp Pathol       Date:  2015-06-01

Review 3.  Small-molecule inhibitors of the Myc oncoprotein.

Authors:  Steven Fletcher; Edward V Prochownik
Journal:  Biochim Biophys Acta       Date:  2014-03-19

4.  mTORC2 in the center of cancer metabolic reprogramming.

Authors:  Kenta Masui; Webster K Cavenee; Paul S Mischel
Journal:  Trends Endocrinol Metab       Date:  2014-05-21       Impact factor: 12.015

5.  Binding cavities and druggability of intrinsically disordered proteins.

Authors:  Yugang Zhang; Huaiqing Cao; Zhirong Liu
Journal:  Protein Sci       Date:  2015-02-24       Impact factor: 6.725

6.  Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library.

Authors:  Landon R Whitby; Kristopher E Boyle; Lifeng Cai; Xiaoqian Yu; Miriam Gochin; Dale L Boger
Journal:  Bioorg Med Chem Lett       Date:  2012-03-03       Impact factor: 2.823

Review 7.  Intrinsically disordered proteins are potential drug targets.

Authors:  Steven J Metallo
Journal:  Curr Opin Chem Biol       Date:  2010-07-02       Impact factor: 8.822

Review 8.  Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases.

Authors:  Vladimir N Uversky; Vrushank Davé; Lilia M Iakoucheva; Prerna Malaney; Steven J Metallo; Ravi Ramesh Pathak; Andreas C Joerger
Journal:  Chem Rev       Date:  2014-05-15       Impact factor: 60.622

Review 9.  Therapeutic strategies to inhibit MYC.

Authors:  Michael R McKeown; James E Bradner
Journal:  Cold Spring Harb Perspect Med       Date:  2014-10-01       Impact factor: 6.915

10.  c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain.

Authors:  Alice Wey; Paul S Knoepfler
Journal:  Oncotarget       Date:  2010-06
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