Literature DB >> 19795893

Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle.

Dipanjan Pan1, Todd A Williams, Angana Senpan, John S Allen, Mike J Scott, Patrick J Gaffney, Samuel A Wickline, Gregory M Lanza.   

Abstract

A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.

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Year:  2009        PMID： 19795893      PMCID： PMC2826244          DOI： 10.1021/ja906797z

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  23 in total

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Review 2.  Cross-linked block copolymer micelles: functional nanostructures of great potential and versatility.

Authors:  Rachel K O'Reilly; Craig J Hawker; Karen L Wooley
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3.  Experimental feasibility of multi-energy photon-counting K-edge imaging in pre-clinical computed tomography.

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Journal:  Phys Med Biol       Date:  2008-07-08       Impact factor: 3.609

4.  Quantification of in-plane motion of the coronary arteries during the cardiac cycle: implications for acquisition window duration for MR flow quantification.

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5.  Molecular MR imaging of melanoma angiogenesis with alphanubeta3-targeted paramagnetic nanoparticles.

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Journal:  Magn Reson Med       Date:  2005-03       Impact factor: 4.668

6.  The use of gold nanoparticles to enhance radiotherapy in mice.

Authors:  James F Hainfeld; Daniel N Slatkin; Henry M Smilowitz
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7.  An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles.

Authors:  Oded Rabin; J Manuel Perez; Jan Grimm; Gregory Wojtkiewicz; Ralph Weissleder
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Review 8.  The convergence of synthetic organic and polymer chemistries.

Authors:  Craig J Hawker; Karen L Wooley
Journal:  Science       Date:  2005-08-19       Impact factor: 47.728

9.  In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent.

Authors:  René M Botnar; Alexandra S Perez; Sonia Witte; Andrea J Wiethoff; James Laredo; James Hamilton; William Quist; Edward C Parsons; Anand Vaidya; Andrew Kolodziej; John A Barrett; Philip B Graham; Robert M Weisskoff; Warren J Manning; Michael T Johnstone
Journal:  Circulation       Date:  2004-04-05       Impact factor: 29.690

10.  Dual-energy CT for the assessment of contrast material distribution in the pulmonary parenchyma.

Authors:  Sven F Thieme; Thorsten R C Johnson; Christopher Lee; Justin McWilliams; Christoph R Becker; Maximilian F Reiser; Konstantin Nikolaou
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  26 in total

Review 1.  Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features.

Authors:  John C Stendahl; Albert J Sinusas
Journal:  J Nucl Med       Date:  2015-08-13       Impact factor: 10.057

Review 2.  Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases.

Authors:  Biana Godin; Jason H Sakamoto; Rita E Serda; Alessandro Grattoni; Ali Bouamrani; Mauro Ferrari
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Review 3.  Cardiovascular molecular imaging: focus on clinical translation.

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Review 4.  Nanocarriers for tracking and treating diseases.

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Review 5.  Vision 20/20: Single photon counting x-ray detectors in medical imaging.

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Review 6.  Nanomedicine strategies for molecular targets with MRI and optical imaging.

Authors:  Dipanjan Pan; Shelton D Caruthers; Junjie Chen; Patrick M Winter; Angana SenPan; Anne H Schmieder; Samuel A Wickline; Gregory M Lanza
Journal:  Future Med Chem       Date:  2010-03       Impact factor: 3.808

7.  Bismuth@US-tubes as a Potential Contrast Agent for X-ray Imaging Applications.

Authors:  Eladio J Rivera; Lesa A Tran; Mayra Hernández-Rivera; Diana Yoon; Antonios G Mikos; Irene A Rusakova; Benjamin Y Cheong; Maria da Graça Cabreira-Hansen; James T Willerson; Emerson C Perin; Lon J Wilson
Journal:  J Mater Chem B       Date:  2013-10-07       Impact factor: 6.331

Review 8.  Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies.

Authors:  Benjamin M Yeh; Paul F FitzGerald; Peter M Edic; Jack W Lambert; Robert E Colborn; Michael E Marino; Paul M Evans; Jeannette C Roberts; Zhen J Wang; Margaret J Wong; Peter J Bonitatibus
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9.  Zr- and Hf-based nanoscale metal-organic frameworks as contrast agents for computed tomography.

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10.  Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent.

Authors:  Rohan Bhavane; Cristian Badea; Ketan B Ghaghada; Darin Clark; Deborah Vela; Anoosha Moturu; Akshaya Annapragada; G Allan Johnson; James T Willerson; Ananth Annapragada
Journal:  Circ Cardiovasc Imaging       Date:  2013-01-24       Impact factor: 7.792
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