Literature DB >> 23049169

Zr- and Hf-based nanoscale metal-organic frameworks as contrast agents for computed tomography.

Kathryn E Dekrafft1, William S Boyle, Laurel M Burk, Otto Z Zhou, Wenbin Lin.   

Abstract

Nanoscale metal-organic frameworks (NMOFs) of the UiO-66 structure containing high Zr (37 wt%) and Hf (57 wt%) content were synthesized and characterized, and their potential as contrast agents for X-ray computed tomography (CT) imaging was evaluated. Hf-NMOFs of different sizes were coated with silica and poly(ethylene glycol) (PEG) to enhance biocompatibility, and were used for in vivo CT imaging of mice, showing increased attenuation in the liver and spleen.

Entities:  

Year:  2012        PMID： 23049169      PMCID： PMC3462458          DOI： 10.1039/C2JM32299D

Source DB:  PubMed          Journal:  J Mater Chem        ISSN： 0959-9428


  36 in total

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Review 10.  Modular synthesis of functional nanoscale coordination polymers.

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  25 in total

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Review 8.  High-Z Metal-Organic Frameworks for X-ray Radiation-Based Cancer Theranostics.

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Review 9.  Application of liposomal technologies for delivery of platinum analogs in oncology.

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