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Literature DB >> 19768466

Epigenetic factors in aging and longevity.

Abstract

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to changes in the underlying DNA sequence, most notably chromatin remodeling driven by histone modifications, and DNA methylation. Such variation is transmitted by cell division, but generally not passed on through the germ line. An increasing body of evidence supports a role for epigenetic changes in the etiology of aging and its associated disease sequelae. Here, we review the role of epigenetics in aging and longevity with a focus on DNA methylation. Increased understanding of those aging-related processes that are driven by epigenetic mechanisms will allow for the development of novel epigenetic-based diagnostic, preventive, and therapeutic strategies for age-related diseases.

Mesh：

Year: 2009 PMID： 19768466 DOI： 10.1007/s00424-009-0730-7

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

114 in total

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Authors: Amir Eden; François Gaudet; Alpana Waghmare; Rudolf Jaenisch
Journal: Science Date: 2003-04-18 Impact factor: 47.728

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Journal: Science Date: 2003-12-11 Impact factor: 47.728

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Journal: Lancet Date: 2003-08-09 Impact factor: 79.321

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Journal: Bioinformatics Date: 2009-06-26 Impact factor: 6.937

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Journal: Proc Natl Acad Sci U S A Date: 2006-05-31 Impact factor: 11.205

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Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

8. Telomeres shorten during ageing of human fibroblasts.

Authors: C B Harley; A B Futcher; C W Greider
Journal: Nature Date: 1990-05-31 Impact factor: 49.962

Review 9. Epigenetics as a mechanism driving polygenic clinical drug resistance.

Authors: R M Glasspool; J M Teodoridis; R Brown
Journal: Br J Cancer Date: 2006-04-24 Impact factor: 7.640

10. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome.

Authors: Dana C Dolinoy; Jennifer R Weidman; Robert A Waterland; Randy L Jirtle
Journal: Environ Health Perspect Date: 2006-04 Impact factor: 9.031

39 in total

Review 1. Apoptosis and aging: increased resistance to apoptosis enhances the aging process.

Authors: Antero Salminen; Johanna Ojala; Kai Kaarniranta
Journal: Cell Mol Life Sci Date: 2010-11-30 Impact factor: 9.261

2. A role for DNA methylation in regulation of EphA5 receptor expression in the mouse retina.

Authors: Tihomira D Petkova; Gail M Seigel; Deborah C Otteson
Journal: Vision Res Date: 2010-09-25 Impact factor: 1.886

3. Lifestyle factors of people with exceptional longevity.

Authors: Swapnil N Rajpathak; Yingheng Liu; Orit Ben-David; Saritha Reddy; Gil Atzmon; Jill Crandall; Nir Barzilai
Journal: J Am Geriatr Soc Date: 2011-08-03 Impact factor: 5.562

4. Global DNA methylation in old subjects is correlated with frailty.

Authors: Dina Bellizzi; Patrizia D'Aquila; Alberto Montesanto; Andrea Corsonello; Vincenzo Mari; Bruno Mazzei; Fabrizia Lattanzio; Giuseppe Passarino
Journal: Age (Dordr) Date: 2011-02-19

5. DNA methylation analysis of SOCS1, SOCS3, and LINE-1 in microdissected gingival tissue.

Authors: Denise C Andia; Aline C Planello; Danielle Portinho; Rodrigo A da Silva; Cristiane R Salmon; Enilson A Sallum; Francisco H Nociti Junior; Ana P de Souza
Journal: Clin Oral Investig Date: 2015-04-07 Impact factor: 3.573

6. GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.

Authors: Linda Broer; Aron S Buchman; Joris Deelen; Daniel S Evans; Jessica D Faul; Kathryn L Lunetta; Paola Sebastiani; Jennifer A Smith; Albert V Smith; Toshiko Tanaka; Lei Yu; Alice M Arnold; Thor Aspelund; Emelia J Benjamin; Philip L De Jager; Gudny Eirkisdottir; Denis A Evans; Melissa E Garcia; Albert Hofman; Robert C Kaplan; Sharon L R Kardia; Douglas P Kiel; Ben A Oostra; Eric S Orwoll; Neeta Parimi; Bruce M Psaty; Fernando Rivadeneira; Jerome I Rotter; Sudha Seshadri; Andrew Singleton; Henning Tiemeier; André G Uitterlinden; Wei Zhao; Stefania Bandinelli; David A Bennett; Luigi Ferrucci; Vilmundur Gudnason; Tamara B Harris; David Karasik; Lenore J Launer; Thomas T Perls; P Eline Slagboom; Gregory J Tranah; David R Weir; Anne B Newman; Cornelia M van Duijn; Joanne M Murabito
Journal: J Gerontol A Biol Sci Med Sci Date: 2014-09-08 Impact factor: 6.053