Literature DB >> 19767755

Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

Meredith Yeager1, Nilanjan Chatterjee, Julia Ciampa, Kevin B Jacobs, Jesus Gonzalez-Bosquet, Richard B Hayes, Peter Kraft, Sholom Wacholder, Nick Orr, Sonja Berndt, Kai Yu, Amy Hutchinson, Zhaoming Wang, Laufey Amundadottir, Heather Spencer Feigelson, Michael J Thun, W Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Fredrick R Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, E David Crawford, Christopher A Haiman, Brian Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Timothy J Key, Rudolf Kaaks, William Isaacs, Sarah Isaacs, Kathleen E Wiley, Henrik Gronberg, Fredrik Wiklund, Pär Stattin, Jianfeng Xu, S Lilly Zheng, Jielin Sun, Lars J Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Daniela S Gerhard, Robert N Hoover, Joseph F Fraumeni, David J Hunter, Gilles Thomas, Stephen J Chanock.   

Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

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Year:  2009        PMID： 19767755      PMCID： PMC3430510          DOI： 10.1038/ng.444

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  13 in total

1.  A common variant associated with prostate cancer in European and African populations.

Authors:  Laufey T Amundadottir; Patrick Sulem; Julius Gudmundsson; Agnar Helgason; Adam Baker; Bjarni A Agnarsson; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Jean-Baptiste Cazier; Jesus Sainz; Margret Jakobsdottir; Jelena Kostic; Droplaug N Magnusdottir; Shyamali Ghosh; Kari Agnarsson; Birgitta Birgisdottir; Louise Le Roux; Adalheidur Olafsdottir; Thorarinn Blondal; Margret Andresdottir; Olafia Svandis Gretarsdottir; Jon T Bergthorsson; Daniel Gudbjartsson; Arnaldur Gylfason; Gudmar Thorleifsson; Andrei Manolescu; Kristleifur Kristjansson; Gudmundur Geirsson; Helgi Isaksson; Julie Douglas; Jan-Erik Johansson; Katarina Bälter; Fredrik Wiklund; James E Montie; Xiaoying Yu; Brian K Suarez; Carole Ober; Kathleen A Cooney; Henrik Gronberg; William J Catalona; Gudmundur V Einarsson; Rosa B Barkardottir; Jeffrey R Gulcher; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson
Journal:  Nat Genet       Date:  2006-05-07       Impact factor: 38.330

2.  Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.

Authors:  Matthew L Freedman; Christopher A Haiman; Nick Patterson; Gavin J McDonald; Arti Tandon; Alicja Waliszewska; Kathryn Penney; Robert G Steen; Kristin Ardlie; Esther M John; Ingrid Oakley-Girvan; Alice S Whittemore; Kathleen A Cooney; Sue A Ingles; David Altshuler; Brian E Henderson; David Reich
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-31       Impact factor: 11.205

3.  Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

Authors:  Julius Gudmundsson; Patrick Sulem; Andrei Manolescu; Laufey T Amundadottir; Daniel Gudbjartsson; Agnar Helgason; Thorunn Rafnar; Jon T Bergthorsson; Bjarni A Agnarsson; Adam Baker; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Margret Jakobsdottir; Jianfeng Xu; Thorarinn Blondal; Jelena Kostic; Jielin Sun; Shyamali Ghosh; Simon N Stacey; Magali Mouy; Jona Saemundsdottir; Valgerdur M Backman; Kristleifur Kristjansson; Alejandro Tres; Alan W Partin; Marjo T Albers-Akkers; Javier Godino-Ivan Marcos; Patrick C Walsh; Dorine W Swinkels; Sebastian Navarrete; Sarah D Isaacs; Katja K Aben; Theresa Graif; John Cashy; Manuel Ruiz-Echarri; Kathleen E Wiley; Brian K Suarez; J Alfred Witjes; Mike Frigge; Carole Ober; Eirikur Jonsson; Gudmundur V Einarsson; Jose I Mayordomo; Lambertus A Kiemeney; William B Isaacs; William J Catalona; Rosa B Barkardottir; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Nat Genet       Date:  2007-04-01       Impact factor: 38.330

4.  A range of cancers is associated with the rs6983267 marker on chromosome 8.

Authors:  Dominika Wokolorczyk; Bartlomiej Gliniewicz; Andrzej Sikorski; Elzbieta Zlowocka; Bartlomiej Masojc; Tadeusz Debniak; Joanna Matyjasik; Marek Mierzejewski; Krzysztof Medrek; Dorota Oszutowska; Janina Suchy; Jacek Gronwald; Urszula Teodorczyk; Tomasz Huzarski; Tomasz Byrski; Anna Jakubowska; Bohdan Górski; Thierry van de Wetering; Swietlana Walczak; Steven A Narod; Jan Lubinski; Cezary Cybulski
Journal:  Cancer Res       Date:  2008-12-01       Impact factor: 12.701

5.  Multiple loci with different cancer specificities within the 8q24 gene desert.

Authors:  Maya Ghoussaini; Honglin Song; Thibaud Koessler; Ali Amin Al Olama; Zsofia Kote-Jarai; Kristy E Driver; Karen A Pooley; Susan J Ramus; Susanne Krüger Kjaer; Estrid Hogdall; Richard A DiCioccio; Alice S Whittemore; Simon A Gayther; Graham G Giles; Michelle Guy; Stephen M Edwards; Jonathan Morrison; Jenny L Donovan; Freddie C Hamdy; David P Dearnaley; Audrey T Ardern-Jones; Amanda L Hall; Lynne T O'Brien; Beatrice N Gehr-Swain; Rosemary A Wilkinson; Paul M Brown; John L Hopper; David E Neal; Paul D P Pharoah; Bruce A J Ponder; Rosalind A Eeles; Douglas F Easton; Alison M Dunning
Journal:  J Natl Cancer Inst       Date:  2008-06-24       Impact factor: 13.506

6.  Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.

Authors:  Sonja I Berndt; John D Potter; Aditi Hazra; Meredith Yeager; Gilles Thomas; Karen W Makar; Robert Welch; Amanda J Cross; Wen-Yi Huang; Robert E Schoen; Edward Giovannucci; Andrew T Chan; Stephen J Chanock; Ulrike Peters; David J Hunter; Richard B Hayes
Journal:  Hum Mol Genet       Date:  2008-06-04       Impact factor: 6.150

7.  A common genetic risk factor for colorectal and prostate cancer.

Authors:  Christopher A Haiman; Loïc Le Marchand; Jennifer Yamamato; Daniel O Stram; Xin Sheng; Laurence N Kolonel; Anna H Wu; David Reich; Brian E Henderson
Journal:  Nat Genet       Date:  2007-07-08       Impact factor: 38.330

8.  Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

Authors:  Brent W Zanke; Celia M T Greenwood; Jagadish Rangrej; Rafal Kustra; Albert Tenesa; Susan M Farrington; James Prendergast; Sylviane Olschwang; Theodore Chiang; Edgar Crowdy; Vincent Ferretti; Philippe Laflamme; Saravanan Sundararajan; Stéphanie Roumy; Jean-François Olivier; Frédérick Robidoux; Robert Sladek; Alexandre Montpetit; Peter Campbell; Stephane Bezieau; Anne Marie O'Shea; George Zogopoulos; Michelle Cotterchio; Polly Newcomb; John McLaughlin; Ban Younghusband; Roger Green; Jane Green; Mary E M Porteous; Harry Campbell; Helene Blanche; Mourad Sahbatou; Emmanuel Tubacher; Catherine Bonaiti-Pellié; Bruno Buecher; Elio Riboli; Sebastien Kury; Stephen J Chanock; John Potter; Gilles Thomas; Steven Gallinger; Thomas J Hudson; Malcolm G Dunlop
Journal:  Nat Genet       Date:  2007-07-08       Impact factor: 38.330

9.  A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.

Authors:  Ian Tomlinson; Emily Webb; Luis Carvajal-Carmona; Peter Broderick; Zoe Kemp; Sarah Spain; Steven Penegar; Ian Chandler; Maggie Gorman; Wendy Wood; Ella Barclay; Steven Lubbe; Lynn Martin; Gabrielle Sellick; Emma Jaeger; Richard Hubner; Ruth Wild; Andrew Rowan; Sarah Fielding; Kimberley Howarth; Andrew Silver; Wendy Atkin; Kenneth Muir; Richard Logan; David Kerr; Elaine Johnstone; Oliver Sieber; Richard Gray; Huw Thomas; Julian Peto; Jean-Baptiste Cazier; Richard Houlston
Journal:  Nat Genet       Date:  2007-07-08       Impact factor: 38.330

10.  Genome-wide association study identifies novel breast cancer susceptibility loci.

Authors:  Douglas F Easton; Karen A Pooley; Alison M Dunning; Paul D P Pharoah; Deborah Thompson; Dennis G Ballinger; Jeffery P Struewing; Jonathan Morrison; Helen Field; Robert Luben; Nicholas Wareham; Shahana Ahmed; Catherine S Healey; Richard Bowman; Kerstin B Meyer; Christopher A Haiman; Laurence K Kolonel; Brian E Henderson; Loic Le Marchand; Paul Brennan; Suleeporn Sangrajrang; Valerie Gaborieau; Fabrice Odefrey; Chen-Yang Shen; Pei-Ei Wu; Hui-Chun Wang; Diana Eccles; D Gareth Evans; Julian Peto; Olivia Fletcher; Nichola Johnson; Sheila Seal; Michael R Stratton; Nazneen Rahman; Georgia Chenevix-Trench; Stig E Bojesen; Børge G Nordestgaard; Christen K Axelsson; Montserrat Garcia-Closas; Louise Brinton; Stephen Chanock; Jolanta Lissowska; Beata Peplonska; Heli Nevanlinna; Rainer Fagerholm; Hannaleena Eerola; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Sei-Hyun Ahn; David J Hunter; Susan E Hankinson; David G Cox; Per Hall; Sara Wedren; Jianjun Liu; Yen-Ling Low; Natalia Bogdanova; Peter Schürmann; Thilo Dörk; Rob A E M Tollenaar; Catharina E Jacobi; Peter Devilee; Jan G M Klijn; Alice J Sigurdson; Michele M Doody; Bruce H Alexander; Jinghui Zhang; Angela Cox; Ian W Brock; Gordon MacPherson; Malcolm W R Reed; Fergus J Couch; Ellen L Goode; Janet E Olson; Hanne Meijers-Heijboer; Ans van den Ouweland; André Uitterlinden; Fernando Rivadeneira; Roger L Milne; Gloria Ribas; Anna Gonzalez-Neira; Javier Benitez; John L Hopper; Margaret McCredie; Melissa Southey; Graham G Giles; Chris Schroen; Christina Justenhoven; Hiltrud Brauch; Ute Hamann; Yon-Dschun Ko; Amanda B Spurdle; Jonathan Beesley; Xiaoqing Chen; Arto Mannermaa; Veli-Matti Kosma; Vesa Kataja; Jaana Hartikainen; Nicholas E Day; David R Cox; Bruce A J Ponder
Journal:  Nature       Date:  2007-06-28       Impact factor: 49.962
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  139 in total

1.  Assessing the clinical role of genetic markers of early-onset prostate cancer among high-risk men enrolled in prostate cancer early detection.

Authors:  Lucinda Hughes; Fang Zhu; Eric Ross; Laura Gross; Robert G Uzzo; David Y T Chen; Rosalia Viterbo; Timothy R Rebbeck; Veda N Giri
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2011-12-05       Impact factor: 4.254

2.  Genetic variation at chromosome 8q24 in osteosarcoma cases and controls.

Authors:  Lisa Mirabello; Sonja I Berndt; Guillermo F Seratti; Laurie Burdett; Meredith Yeager; Salma Chowdhury; Kedest Teshome; Arinze Uzoka; Chester Douglass; Richard B Hayes; Robert N Hoover; Sharon A Savage
Journal:  Carcinogenesis       Date:  2010-06-07       Impact factor: 4.944

3.  Genome-wide detection of natural selection in African Americans pre- and post-admixture.

Authors:  Wenfei Jin; Shuhua Xu; Haifeng Wang; Yongguo Yu; Yiping Shen; Bailin Wu; Li Jin
Journal:  Genome Res       Date:  2011-11-29       Impact factor: 9.043

4.  In vivo exploration of the functional activity of the non-coding 8q24 prostate cancer risk locus.

Authors:  Dolores J Lamb; Mounia Tannour-Louet
Journal:  Asian J Androl       Date:  2010-09-06       Impact factor: 3.285

5.  Novel genetic loci associated with prostate cancer in the Japanese population.

Authors:  Yin Sun; Jiao-Ti Huang
Journal:  Asian J Androl       Date:  2010-10-11       Impact factor: 3.285

Review 6.  A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.

Authors:  John P A Ioannidis; Peter Castaldi; Evangelos Evangelou
Journal:  J Natl Cancer Inst       Date:  2010-05-26       Impact factor: 13.506

7.  Comparison of two methods for estimating absolute risk of prostate cancer based on single nucleotide polymorphisms and family history.

Authors:  Fang-Chi Hsu; Jielin Sun; Yi Zhu; Seong-Tae Kim; Tao Jin; Zheng Zhang; Fredrik Wiklund; A Karim Kader; S Lilly Zheng; William Isaacs; Henrik Grönberg; Jianfeng Xu
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-03-23       Impact factor: 4.254

8.  One thousand genomes imputation in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium aggressive prostate cancer genome-wide association study.

Authors:  Mitchell J Machiela; Constance Chen; Liming Liang; W Ryan Diver; Victoria L Stevens; Konstantinos K Tsilidis; Christopher A Haiman; Stephen J Chanock; David J Hunter; Peter Kraft
Journal:  Prostate       Date:  2012-12-19       Impact factor: 4.104

9.  Genome-wide association studies in cancer--current and future directions.

Authors:  Charles C Chung; Wagner C S Magalhaes; Jesus Gonzalez-Bosquet; Stephen J Chanock
Journal:  Carcinogenesis       Date:  2009-11-11       Impact factor: 4.944

10.  Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

Authors:  Jianfeng Xu; Siqun Lilly Zheng; Sarah D Isaacs; Kathleen E Wiley; Fredrik Wiklund; Jielin Sun; A Karim Kader; Ge Li; Lina D Purcell; Seong-Tae Kim; Fang-Chi Hsu; Pär Stattin; Jonas Hugosson; Jan Adolfsson; Patrick C Walsh; Jeffrey M Trent; David Duggan; John Carpten; Henrik Grönberg; William B Isaacs
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-11       Impact factor: 11.205
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