Literature DB >> 17618282

A common genetic risk factor for colorectal and prostate cancer.

Christopher A Haiman1, Loïc Le Marchand, Jennifer Yamamato, Daniel O Stram, Xin Sheng, Laurence N Kolonel, Anna H Wu, David Reich, Brian E Henderson.   

Abstract

Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 x 10(-6)) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.

Entities:  

Mesh：

Year:  2007        PMID： 17618282      PMCID： PMC2391283          DOI： 10.1038/ng2098

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  13 in total

1.  A common variant associated with prostate cancer in European and African populations.

Authors:  Laufey T Amundadottir; Patrick Sulem; Julius Gudmundsson; Agnar Helgason; Adam Baker; Bjarni A Agnarsson; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Jean-Baptiste Cazier; Jesus Sainz; Margret Jakobsdottir; Jelena Kostic; Droplaug N Magnusdottir; Shyamali Ghosh; Kari Agnarsson; Birgitta Birgisdottir; Louise Le Roux; Adalheidur Olafsdottir; Thorarinn Blondal; Margret Andresdottir; Olafia Svandis Gretarsdottir; Jon T Bergthorsson; Daniel Gudbjartsson; Arnaldur Gylfason; Gudmar Thorleifsson; Andrei Manolescu; Kristleifur Kristjansson; Gudmundur Geirsson; Helgi Isaksson; Julie Douglas; Jan-Erik Johansson; Katarina Bälter; Fredrik Wiklund; James E Montie; Xiaoying Yu; Brian K Suarez; Carole Ober; Kathleen A Cooney; Henrik Gronberg; William J Catalona; Gudmundur V Einarsson; Rosa B Barkardottir; Jeffrey R Gulcher; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson
Journal:  Nat Genet       Date:  2006-05-07       Impact factor: 38.330

2.  Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.

Authors:  Matthew L Freedman; Christopher A Haiman; Nick Patterson; Gavin J McDonald; Arti Tandon; Alicja Waliszewska; Kathryn Penney; Robert G Steen; Kristin Ardlie; Esther M John; Ingrid Oakley-Girvan; Alice S Whittemore; Kathleen A Cooney; Sue A Ingles; David Altshuler; Brian E Henderson; David Reich
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-31       Impact factor: 11.205

3.  Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.

Authors:  J Nichols; B Zevnik; K Anastassiadis; H Niwa; D Klewe-Nebenius; I Chambers; H Schöler; A Smith
Journal:  Cell       Date:  1998-10-30       Impact factor: 41.582

4.  Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

Authors:  Julius Gudmundsson; Patrick Sulem; Andrei Manolescu; Laufey T Amundadottir; Daniel Gudbjartsson; Agnar Helgason; Thorunn Rafnar; Jon T Bergthorsson; Bjarni A Agnarsson; Adam Baker; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Margret Jakobsdottir; Jianfeng Xu; Thorarinn Blondal; Jelena Kostic; Jielin Sun; Shyamali Ghosh; Simon N Stacey; Magali Mouy; Jona Saemundsdottir; Valgerdur M Backman; Kristleifur Kristjansson; Alejandro Tres; Alan W Partin; Marjo T Albers-Akkers; Javier Godino-Ivan Marcos; Patrick C Walsh; Dorine W Swinkels; Sebastian Navarrete; Sarah D Isaacs; Katja K Aben; Theresa Graif; John Cashy; Manuel Ruiz-Echarri; Kathleen E Wiley; Brian K Suarez; J Alfred Witjes; Mike Frigge; Carole Ober; Eirikur Jonsson; Gudmundur V Einarsson; Jose I Mayordomo; Lambertus A Kiemeney; William B Isaacs; William J Catalona; Rosa B Barkardottir; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Nat Genet       Date:  2007-04-01       Impact factor: 38.330

5.  Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.

Authors:  Meredith Yeager; Nick Orr; Richard B Hayes; Kevin B Jacobs; Peter Kraft; Sholom Wacholder; Mark J Minichiello; Paul Fearnhead; Kai Yu; Nilanjan Chatterjee; Zhaoming Wang; Robert Welch; Brian J Staats; Eugenia E Calle; Heather Spencer Feigelson; Michael J Thun; Carmen Rodriguez; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R Schumacher; Edward Giovannucci; Walter C Willett; Geraldine Cancel-Tassin; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; Edward P Gelmann; Margaret Tucker; Daniela S Gerhard; Joseph F Fraumeni; Robert Hoover; David J Hunter; Stephen J Chanock; Gilles Thomas
Journal:  Nat Genet       Date:  2007-04-01       Impact factor: 38.330

6.  Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors.

Authors:  T Ried; R Knutzen; R Steinbeck; H Blegen; E Schröck; K Heselmeyer; S du Manoir; G Auer
Journal:  Genes Chromosomes Cancer       Date:  1996-04       Impact factor: 5.006

7.  Oct4 pseudogenes are transcribed in cancers.

Authors:  Guangli Suo; Jin Han; Xia Wang; Jingyu Zhang; Yannan Zhao; Yanhong Zhao; Jianwu Dai
Journal:  Biochem Biophys Res Commun       Date:  2005-10-04       Impact factor: 3.575

8.  Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas.

Authors:  Eleanor J Douglas; Heike Fiegler; Andrew Rowan; Sarah Halford; David C Bicknell; Walter Bodmer; Ian P M Tomlinson; Nigel P Carter
Journal:  Cancer Res       Date:  2004-07-15       Impact factor: 12.701

9.  DNA copy number alterations in prostate cancers: a combined analysis of published CGH studies.

Authors:  Jishan Sun; Wennuan Liu; Tamara S Adams; Jielin Sun; Xingnan Li; Aubrey R Turner; Baoli Chang; Jin Woo Kim; Siqun Lilly Zheng; William B Isaacs; Jianfeng Xu
Journal:  Prostate       Date:  2007-05-15       Impact factor: 4.104

10.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Authors: 
Journal:  Nature       Date:  2007-06-07       Impact factor: 49.962
View more
  179 in total

1.  GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes.

Authors:  Jingyao Dai; Jian Gu; Maosheng Huang; Cathy Eng; E Scott Kopetz; Lee M Ellis; Ernest Hawk; Xifeng Wu
Journal:  Carcinogenesis       Date:  2012-04-12       Impact factor: 4.944

2.  Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data.

Authors:  Lin S Chen; Carolyn M Hutter; John D Potter; Yan Liu; Ross L Prentice; Ulrike Peters; Li Hsu
Journal:  Am J Hum Genet       Date:  2010-06-11       Impact factor: 11.025

3.  Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.

Authors:  Jing He; Lynne R Wilkens; Daniel O Stram; Laurence N Kolonel; Brian E Henderson; Anna H Wu; Loic Le Marchand; Christopher A Haiman
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-11-11       Impact factor: 4.254

4.  Low-penetrance susceptibility variants in familial colorectal cancer.

Authors:  Iina Niittymäki; Eevi Kaasinen; Sari Tuupanen; Auli Karhu; Heikki Järvinen; Jukka-Pekka Mecklin; Ian P M Tomlinson; Maria Chiara Di Bernardo; Richard S Houlston; Lauri A Aaltonen
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-05-25       Impact factor: 4.254

5.  The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.

Authors:  Ruta Sahasrabudhe; Ana Estrada; Paul Lott; Lynn Martin; Guadalupe Polanco Echeverry; Alejandro Velez; Gila Neta; Meiko Takahasi; Vladimir Saenko; Norisato Mitsutake; Emma Jaeguer; Carlos Simon Duque; Alejandro Rios; Mabel Bohorquez; Rodrigo Prieto; Angel Criollo; Magdalena Echeverry; Ian Tomlinson; Luis G Carvajal Carmona
Journal:  Endocr Relat Cancer       Date:  2015-08-19       Impact factor: 5.678

6.  Common genetic variants in the 8q24 region and risk of papillary thyroid cancer.

Authors:  Gila Neta; Chu-Ling Yu; Alina Brenner; Fangyi Gu; Amy Hutchinson; Ruth Pfeiffer; Erich M Sturgis; Li Xu; Martha S Linet; Bruce H Alexander; Stephen Chanock; Alice J Sigurdson
Journal:  Laryngoscope       Date:  2012-01-24       Impact factor: 3.325

7.  Networks of intergenic long-range enhancers and snpRNAs drive castration-resistant phenotype of prostate cancer and contribute to pathogenesis of multiple common human disorders.

Authors:  Anna B Glinskii; Shuang Ma; Jun Ma; Denise Grant; Chang-Uk Lim; Ian Guest; Stewart Sell; Ralph Buttyan; Gennadi V Glinsky
Journal:  Cell Cycle       Date:  2011-10-15       Impact factor: 4.534

8.  An expressed retrogene of the master embryonic stem cell gene POU5F1 is associated with prostate cancer susceptibility.

Authors:  Joan P Breyer; Daniel C Dorset; Travis A Clark; Kevin M Bradley; Tiina A Wahlfors; Kate M McReynolds; William H Maynard; Sam S Chang; Michael S Cookson; Joseph A Smith; Johanna Schleutker; William D Dupont; Jeffrey R Smith
Journal:  Am J Hum Genet       Date:  2014-02-27       Impact factor: 11.025

9.  Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites.

Authors:  Sungshim Lani Park; Shen-Chih Chang; Lin Cai; Carlos Cordon-Cardo; Bao-Guo Ding; Sander Greenland; Shehnaz K Hussain; Qingwu Jiang; Simin Liu; Ming-Lan Lu; Jenny T Mao; Hal Morgenstern; Li-Na Mu; Leslie J Ng; Allan Pantuck; Jianyu Rao; Victor E Reuter; Donald P Tashkin; Nai-Chieh Y You; Can-Qing Yu; Shun-Zhang Yu; Jin-Kou Zhao; Arie Belldegrun; Zuo-Feng Zhang
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-11       Impact factor: 4.254

Review 10.  Polygenic susceptibility to breast cancer: current state-of-the-art.

Authors:  Maya Ghoussaini; Paul D P Pharoah
Journal:  Future Oncol       Date:  2009-06       Impact factor: 3.404
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.