| Literature DB >> 19767754 |
Julius Gudmundsson1, Patrick Sulem, Daniel F Gudbjartsson, Thorarinn Blondal, Arnaldur Gylfason, Bjarni A Agnarsson, Kristrun R Benediktsdottir, Droplaug N Magnusdottir, Gudbjorg Orlygsdottir, Margret Jakobsdottir, Simon N Stacey, Asgeir Sigurdsson, Tiina Wahlfors, Teuvo Tammela, Joan P Breyer, Kate M McReynolds, Kevin M Bradley, Berta Saez, Javier Godino, Sebastian Navarrete, Fernando Fuertes, Laura Murillo, Eduardo Polo, Katja K Aben, Inge M van Oort, Brian K Suarez, Brian T Helfand, Donghui Kan, Carlo Zanon, Michael L Frigge, Kristleifur Kristjansson, Jeffrey R Gulcher, Gudmundur V Einarsson, Eirikur Jonsson, William J Catalona, Jose I Mayordomo, Lambertus A Kiemeney, Jeffrey R Smith, Johanna Schleutker, Rosa B Barkardottir, Augustine Kong, Unnur Thorsteinsdottir, Thorunn Rafnar, Kari Stefansson.
Abstract
We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.Entities:
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Year: 2009 PMID： 19767754 PMCID： PMC3562712 DOI： 10.1038/ng.448
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330