| Literature DB >> 18264098 |
Julius Gudmundsson1, Patrick Sulem, Thorunn Rafnar, Jon T Bergthorsson, Andrei Manolescu, Daniel Gudbjartsson, Bjarni A Agnarsson, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Thorarinn Blondal, Margret Jakobsdottir, Simon N Stacey, Jelena Kostic, Kari T Kristinsson, Birgitta Birgisdottir, Shyamali Ghosh, Droplaug N Magnusdottir, Steinunn Thorlacius, Gudmar Thorleifsson, S Lilly Zheng, Jielin Sun, Bao-Li Chang, J Bradford Elmore, Joan P Breyer, Kate M McReynolds, Kevin M Bradley, Brian L Yaspan, Fredrik Wiklund, Par Stattin, Sara Lindström, Hans-Olov Adami, Shannon K McDonnell, Daniel J Schaid, Julie M Cunningham, Liang Wang, James R Cerhan, Jennifer L St Sauver, Sara D Isaacs, Kathleen E Wiley, Alan W Partin, Patrick C Walsh, Sonia Polo, Manuel Ruiz-Echarri, Sebastian Navarrete, Fernando Fuertes, Berta Saez, Javier Godino, Philip C Weijerman, Dorine W Swinkels, Katja K Aben, J Alfred Witjes, Brian K Suarez, Brian T Helfand, Michael L Frigge, Kristleifur Kristjansson, Carole Ober, Eirikur Jonsson, Gudmundur V Einarsson, Jianfeng Xu, Henrik Gronberg, Jeffrey R Smith, Stephen N Thibodeau, William B Isaacs, William J Catalona, Jose I Mayordomo, Lambertus A Kiemeney, Rosa B Barkardottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong, Kari Stefansson.
Abstract
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.Entities:
Mesh：
Year: 2008 PMID： 18264098 PMCID： PMC3598012 DOI： 10.1038/ng.89
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330