Literature DB >> 18758462

Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.

Jielin Sun1, Siqun Lilly Zheng, Fredrik Wiklund, Sarah D Isaacs, Lina D Purcell, Zhengrong Gao, Fang-Chi Hsu, Seong-Tae Kim, Wennuan Liu, Yi Zhu, Pär Stattin, Hans-Olov Adami, Kathleen E Wiley, Latchezar Dimitrov, Jishan Sun, Tao Li, Aubrey R Turner, Tamara S Adams, Jan Adolfsson, Jan-Erik Johansson, James Lowey, Bruce J Trock, Alan W Partin, Patrick C Walsh, Jeffrey M Trent, David Duggan, John Carpten, Bao-Li Chang, Henrik Grönberg, William B Isaacs, Jianfeng Xu.   

Abstract

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

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Year:  2008        PMID： 18758462      PMCID： PMC3188432          DOI： 10.1038/ng.214

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  14 in total

1.  A new statistical method for haplotype reconstruction from population data.

Authors:  M Stephens; N J Smith; P Donnelly
Journal:  Am J Hum Genet       Date:  2001-03-09       Impact factor: 11.025

2.  A common variant associated with prostate cancer in European and African populations.

Authors:  Laufey T Amundadottir; Patrick Sulem; Julius Gudmundsson; Agnar Helgason; Adam Baker; Bjarni A Agnarsson; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Jean-Baptiste Cazier; Jesus Sainz; Margret Jakobsdottir; Jelena Kostic; Droplaug N Magnusdottir; Shyamali Ghosh; Kari Agnarsson; Birgitta Birgisdottir; Louise Le Roux; Adalheidur Olafsdottir; Thorarinn Blondal; Margret Andresdottir; Olafia Svandis Gretarsdottir; Jon T Bergthorsson; Daniel Gudbjartsson; Arnaldur Gylfason; Gudmar Thorleifsson; Andrei Manolescu; Kristleifur Kristjansson; Gudmundur Geirsson; Helgi Isaksson; Julie Douglas; Jan-Erik Johansson; Katarina Bälter; Fredrik Wiklund; James E Montie; Xiaoying Yu; Brian K Suarez; Carole Ober; Kathleen A Cooney; Henrik Gronberg; William J Catalona; Gudmundur V Einarsson; Rosa B Barkardottir; Jeffrey R Gulcher; Augustine Kong; Unnur Thorsteinsdottir; Kari Stefansson
Journal:  Nat Genet       Date:  2006-05-07       Impact factor: 38.330

3.  Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.

Authors:  Matthew L Freedman; Christopher A Haiman; Nick Patterson; Gavin J McDonald; Arti Tandon; Alicja Waliszewska; Kathryn Penney; Robert G Steen; Kristin Ardlie; Esther M John; Ingrid Oakley-Girvan; Alice S Whittemore; Kathleen A Cooney; Sue A Ingles; David Altshuler; Brian E Henderson; David Reich
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-31       Impact factor: 11.205

4.  A comparison of phasing algorithms for trios and unrelated individuals.

Authors:  Jonathan Marchini; David Cutler; Nick Patterson; Matthew Stephens; Eleazar Eskin; Eran Halperin; Shin Lin; Zhaohui S Qin; Heather M Munro; Goncalo R Abecasis; Peter Donnelly
Journal:  Am J Hum Genet       Date:  2006-01-26       Impact factor: 11.025

5.  Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.

Authors:  Julius Gudmundsson; Patrick Sulem; Valgerdur Steinthorsdottir; Jon T Bergthorsson; Gudmar Thorleifsson; Andrei Manolescu; Thorunn Rafnar; Daniel Gudbjartsson; Bjarni A Agnarsson; Adam Baker; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Margret Jakobsdottir; Thorarinn Blondal; Simon N Stacey; Agnar Helgason; Steinunn Gunnarsdottir; Adalheidur Olafsdottir; Kari T Kristinsson; Birgitta Birgisdottir; Shyamali Ghosh; Steinunn Thorlacius; Dana Magnusdottir; Gerdur Stefansdottir; Kristleifur Kristjansson; Yu Bagger; Robert L Wilensky; Muredach P Reilly; Andrew D Morris; Charlotte H Kimber; Adebowale Adeyemo; Yuanxiu Chen; Jie Zhou; Wing-Yee So; Peter C Y Tong; Maggie C Y Ng; Torben Hansen; Gitte Andersen; Knut Borch-Johnsen; Torben Jorgensen; Alejandro Tres; Fernando Fuertes; Manuel Ruiz-Echarri; Laura Asin; Berta Saez; Erica van Boven; Siem Klaver; Dorine W Swinkels; Katja K Aben; Theresa Graif; John Cashy; Brian K Suarez; Onco van Vierssen Trip; Michael L Frigge; Carole Ober; Marten H Hofker; Cisca Wijmenga; Claus Christiansen; Daniel J Rader; Colin N A Palmer; Charles Rotimi; Juliana C N Chan; Oluf Pedersen; Gunnar Sigurdsson; Rafn Benediktsson; Eirikur Jonsson; Gudmundur V Einarsson; Jose I Mayordomo; William J Catalona; Lambertus A Kiemeney; Rosa B Barkardottir; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Nat Genet       Date:  2007-07-01       Impact factor: 38.330

6.  Cumulative association of five genetic variants with prostate cancer.

Authors:  S Lilly Zheng; Jielin Sun; Fredrik Wiklund; Shelly Smith; Pär Stattin; Ge Li; Hans-Olov Adami; Fang-Chi Hsu; Yi Zhu; Katarina Bälter; A Karim Kader; Aubrey R Turner; Wennuan Liu; Eugene R Bleecker; Deborah A Meyers; David Duggan; John D Carpten; Bao-Li Chang; William B Isaacs; Jianfeng Xu; Henrik Grönberg
Journal:  N Engl J Med       Date:  2008-01-16       Impact factor: 91.245

7.  Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

Authors:  Julius Gudmundsson; Patrick Sulem; Andrei Manolescu; Laufey T Amundadottir; Daniel Gudbjartsson; Agnar Helgason; Thorunn Rafnar; Jon T Bergthorsson; Bjarni A Agnarsson; Adam Baker; Asgeir Sigurdsson; Kristrun R Benediktsdottir; Margret Jakobsdottir; Jianfeng Xu; Thorarinn Blondal; Jelena Kostic; Jielin Sun; Shyamali Ghosh; Simon N Stacey; Magali Mouy; Jona Saemundsdottir; Valgerdur M Backman; Kristleifur Kristjansson; Alejandro Tres; Alan W Partin; Marjo T Albers-Akkers; Javier Godino-Ivan Marcos; Patrick C Walsh; Dorine W Swinkels; Sebastian Navarrete; Sarah D Isaacs; Katja K Aben; Theresa Graif; John Cashy; Manuel Ruiz-Echarri; Kathleen E Wiley; Brian K Suarez; J Alfred Witjes; Mike Frigge; Carole Ober; Eirikur Jonsson; Gudmundur V Einarsson; Jose I Mayordomo; Lambertus A Kiemeney; William B Isaacs; William J Catalona; Rosa B Barkardottir; Jeffrey R Gulcher; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Nat Genet       Date:  2007-04-01       Impact factor: 38.330

8.  Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.

Authors:  S Lilly Zheng; Jielin Sun; Yu Cheng; Ge Li; Fang-Chi Hsu; Yi Zhu; Bao-Li Chang; Wennuan Liu; Jin Woo Kim; Aubrey R Turner; Marta Gielzak; Guifang Yan; Sarah D Isaacs; Kathleen E Wiley; Jurga Sauvageot; Huann-Sheng Chen; Robin Gurganus; Leslie A Mangold; Bruce J Trock; Henrik Gronberg; David Duggan; John D Carpten; Alan W Partin; Patrick C Walsh; Jianfeng Xu; William B Isaacs
Journal:  J Natl Cancer Inst       Date:  2007-10-09       Impact factor: 13.506

9.  Multiple newly identified loci associated with prostate cancer susceptibility.

Authors:  Rosalind A Eeles; Zsofia Kote-Jarai; Graham G Giles; Ali Amin Al Olama; Michelle Guy; Sarah K Jugurnauth; Shani Mulholland; Daniel A Leongamornlert; Stephen M Edwards; Jonathan Morrison; Helen I Field; Melissa C Southey; Gianluca Severi; Jenny L Donovan; Freddie C Hamdy; David P Dearnaley; Kenneth R Muir; Charmaine Smith; Melisa Bagnato; Audrey T Ardern-Jones; Amanda L Hall; Lynne T O'Brien; Beatrice N Gehr-Swain; Rosemary A Wilkinson; Angie Cox; Sarah Lewis; Paul M Brown; Sameer G Jhavar; Malgorzata Tymrakiewicz; Artitaya Lophatananon; Sarah L Bryant; Alan Horwich; Robert A Huddart; Vincent S Khoo; Christopher C Parker; Christopher J Woodhouse; Alan Thompson; Tim Christmas; Chris Ogden; Cyril Fisher; Charles Jamieson; Colin S Cooper; Dallas R English; John L Hopper; David E Neal; Douglas F Easton
Journal:  Nat Genet       Date:  2008-02-10       Impact factor: 38.330

10.  Multiple loci identified in a genome-wide association study of prostate cancer.

Authors:  Gilles Thomas; Kevin B Jacobs; Meredith Yeager; Peter Kraft; Sholom Wacholder; Nick Orr; Kai Yu; Nilanjan Chatterjee; Robert Welch; Amy Hutchinson; Andrew Crenshaw; Geraldine Cancel-Tassin; Brian J Staats; Zhaoming Wang; Jesus Gonzalez-Bosquet; Jun Fang; Xiang Deng; Sonja I Berndt; Eugenia E Calle; Heather Spencer Feigelson; Michael J Thun; Carmen Rodriguez; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R Schumacher; Edward Giovannucci; Walter C Willett; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; E David Crawford; Margaret Tucker; Daniela S Gerhard; Joseph F Fraumeni; Robert Hoover; Richard B Hayes; David J Hunter; Stephen J Chanock
Journal:  Nat Genet       Date:  2008-02-10       Impact factor: 38.330
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  100 in total

1.  Comparison of two methods for estimating absolute risk of prostate cancer based on single nucleotide polymorphisms and family history.

Authors:  Fang-Chi Hsu; Jielin Sun; Yi Zhu; Seong-Tae Kim; Tao Jin; Zheng Zhang; Fredrik Wiklund; A Karim Kader; S Lilly Zheng; William Isaacs; Henrik Grönberg; Jianfeng Xu
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-03-23       Impact factor: 4.254

Review 2.  Identification of new genetic risk factors for prostate cancer.

Authors:  Michelle Guy; Zsofia Kote-Jarai; Graham G Giles; Ali Amin Al Olama; Sarah K Jugurnauth; Shani Mulholland; Daniel A Leongamornlert; Stephen M Edwards; Jonathan Morrison; Helen I Field; Melissa C Southey; Gianluca Severi; Jenny L Donovan; Freddie C Hamdy; David P Dearnaley; Kenneth R Muir; Charmaine Smith; Melisa Bagnato; Audrey T Ardern-Jones; Amanda L Hall; Lynne T O'Brien; Beatrice N Gehr-Swain; Rosemary A Wilkinson; Angela Cox; Sarah Lewis; Paul M Brown; Sameer G Jhavar; Malgorzata Tymrakiewicz; Artitaya Lophatananon; Sarah L Bryant; Alan Horwich; Robert A Huddart; Vincent S Khoo; Christopher C Parker; Christopher J Woodhouse; Alan Thompson; Tim Christmas; Chris Ogden; Cyril Fisher; Charles Jameson; Colin S Cooper; Dallas R English; John L Hopper; David E Neal; Douglas F Easton; Rosalind A Eeles
Journal:  Asian J Androl       Date:  2008-12-01       Impact factor: 3.285

Review 3.  Exploring genetic susceptibility to cancer in diverse populations.

Authors:  Christopher A Haiman; Daniel O Stram
Journal:  Curr Opin Genet Dev       Date:  2010-03-30       Impact factor: 5.578

4.  Estimation of absolute risk for prostate cancer using genetic markers and family history.

Authors:  Jianfeng Xu; Jielin Sun; A Karim Kader; Sara Lindström; Fredrik Wiklund; Fang-Chi Hsu; Jan-Erik Johansson; S Lilly Zheng; Gilles Thomas; Richard B Hayes; Peter Kraft; David J Hunter; Stephen J Chanock; William B Isaacs; Henrik Grönberg
Journal:  Prostate       Date:  2009-10-01       Impact factor: 4.104

5.  Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer.

Authors:  Charles C Chung; Julia Ciampa; Meredith Yeager; Kevin B Jacobs; Sonja I Berndt; Richard B Hayes; Jesus Gonzalez-Bosquet; Peter Kraft; Sholom Wacholder; Nick Orr; Kai Yu; Amy Hutchinson; Joseph Boland; Quan Chen; Heather Spencer Feigelson; Michael J Thun; W Ryan Diver; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R Schumacher; Geraldine Cancel-Tassin; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; E David Crawford; Christopher A Haiman; Brian E Henderson; Laurence Kolonel; Loic Le Marchand; Afshan Siddiq; Elio Riboli; Tim J Key; Rudolf Kaaks; William B Isaacs; Sarah D Isaacs; Henrik Grönberg; Fredrik Wiklund; Jianfeng Xu; Lars J Vatten; Kristian Hveem; Inger Njolstad; Daniela S Gerhard; Margaret Tucker; Robert N Hoover; Joseph F Fraumeni; David J Hunter; Gilles Thomas; Nilanjan Chatterjee; Stephen J Chanock
Journal:  Hum Mol Genet       Date:  2011-04-29       Impact factor: 6.150

6.  Large-scale fine mapping of the HNF1B locus and prostate cancer risk.

Authors:  Sonja I Berndt; Joshua Sampson; Meredith Yeager; Kevin B Jacobs; Zhaoming Wang; Amy Hutchinson; Charles Chung; Nick Orr; Sholom Wacholder; Nilanjan Chatterjee; Kai Yu; Peter Kraft; Heather Spencer Feigelson; Michael J Thun; W Ryan Diver; Demetrius Albanes; Jarmo Virtamo; Stephanie Weinstein; Fredrick R Schumacher; Geraldine Cancel-Tassin; Olivier Cussenot; Antoine Valeri; Gerald L Andriole; E David Crawford; Christopher Haiman; Brian Henderson; Laurence Kolonel; Loic Le Marchand; Afshan Siddiq; Elio Riboli; Ruth C Travis; Rudolf Kaaks; William Isaacs; Sarah Isaacs; Kathleen E Wiley; Henrik Gronberg; Fredrik Wiklund; Pär Stattin; Jianfeng Xu; S Lilly Zheng; Jielin Sun; Lars J Vatten; Kristian Hveem; Inger Njølstad; Daniela S Gerhard; Margaret Tucker; Richard B Hayes; Robert N Hoover; Joseph F Fraumeni; David J Hunter; Gilles Thomas; Stephen J Chanock
Journal:  Hum Mol Genet       Date:  2011-05-16       Impact factor: 6.150

7.  Clinical implications of family history of prostate cancer and genetic risk single nucleotide polymorphism (SNP) profiles in an active surveillance cohort.

Authors:  Chee L Goh; Edward J Saunders; Daniel A Leongamornlert; Malgorzata Tymrakiewicz; Karen Thomas; Elizabeth D Selvadurai; Ruth Woode-Amissah; Tokhir Dadaev; Nadiya Mahmud; Elena Castro; David Olmos; Michelle Guy; Koveela Govindasami; Lynne T O'Brien; Amanda L Hall; Rosemary A Wilkinson; Emma J Sawyer; Ali Amin Al Olama; Douglas F Easton; Zsofia Kote-Jarai; Chris C Parker; Rosalind A Eeles
Journal:  BJU Int       Date:  2013-01-15       Impact factor: 5.588

8.  Regulators of gene expression as biomarkers for prostate cancer.

Authors:  Stacey S Willard; Shahriar Koochekpour
Journal:  Am J Cancer Res       Date:  2012-11-20       Impact factor: 6.166

9.  Genome-wide association studies in cancer--current and future directions.

Authors:  Charles C Chung; Wagner C S Magalhaes; Jesus Gonzalez-Bosquet; Stephen J Chanock
Journal:  Carcinogenesis       Date:  2009-11-11       Impact factor: 4.944

10.  Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

Authors:  Jianfeng Xu; Siqun Lilly Zheng; Sarah D Isaacs; Kathleen E Wiley; Fredrik Wiklund; Jielin Sun; A Karim Kader; Ge Li; Lina D Purcell; Seong-Tae Kim; Fang-Chi Hsu; Pär Stattin; Jonas Hugosson; Jan Adolfsson; Patrick C Walsh; Jeffrey M Trent; David Duggan; John Carpten; Henrik Grönberg; William B Isaacs
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-11       Impact factor: 11.205
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