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Literature DB >> 1975844

Biological and molecular variability of human immunodeficiency virus type 2 isolates from The Gambia.

T F Schulz¹, D Whitby, J G Hoad, T Corrah, H Whittle, R A Weiss.

Abstract

Seven new human immunodeficiency virus type 2 (HIV-2) isolates (CBL-20 to CBL-26) from The Gambia were characterized. Their cytopathogenicity and growth in vitro correlated with the severity of clinical disease. CBL-22 was highly sensitive to neutralization by HIV-2 sera and was cross-neutralized by some HIV-1 sera. These findings, the differing sizes of envelope glycoproteins of individual isolates, and the sequence analysis of amplified regions of the viral DNAs show that these HIV-2 isolates from one geographical region in West Africa exhibit biological and genome variability comparable to that observed for HIV-1.

Entities: Species

Keywords: Africa; Africa South Of The Sahara; Biology; Clinical Research; Developing Countries; Diseases; English Speaking Africa; Gambia; Hiv Infections; Immunity; Immunologic Factors; In Vitro; Physiology; Research Methodology; Viral Diseases; Western Africa

Mesh：

Year: 1990 PMID： 1975844 PMCID： PMC248013

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

41 in total

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36 in total

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Journal: J Virol Date: 2010-05-12 Impact factor: 5.103

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