Literature DB >> 20463072

HIV-2 genetic evolution in patients with advanced disease is faster than that in matched HIV-1 patients.

Helena Skar1, Pedro Borrego, Timothy C Wallstrom, Mattias Mild, José Maria Marcelino, Helena Barroso, Nuno Taveira, Thomas Leitner, Jan Albert.   

Abstract

The objective of this study was to estimate and compare the evolutionary rates of HIV-2 and HIV-1. Two HIV-2 data sets from patients with advanced disease were compared to matched HIV-1 data sets. The estimated mean evolutionary rate of HIV-2 was significantly higher than the estimated rate of HIV-1, both in the gp125 and in the V3 region of the env gene. In addition, the rate of synonymous substitutions in gp125 was significantly higher for HIV-2 than for HIV-1, possibly indicating a shorter generation time or higher mutation rate of HIV-2. Thus, the lower virulence of HIV-2 does not appear to translate into a lower rate of evolution.

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Year:  2010        PMID： 20463072      PMCID： PMC2898231          DOI： 10.1128/JVI.02548-09

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


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