Literature DB >> 197530

Isolation and characterization of the opioid peptides from rat pituitary: beta-lipotropin.

M Rubinstein, S Stein, L D Gerber, S Udenfriend.   

Abstract

Rat beta-lipotropin was isolated from 40 anterior pituitaries using high efficiency chromatography columns and sensitive fluorometric methods. The beta-lipotropin was characterized as to molecular weight, amino acid composition, and generation of opioid activity by trypsinization. Other opioid peptides, as well as a precursor to opioid peptides with a molecular weight larger than that of beta-lipotropin, were observed in this tissue.

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Year:  1977        PMID： 197530      PMCID： PMC431409          DOI： 10.1073/pnas.74.7.3052

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  Automatic Monitoring of primary amines in preparative column effluents with fluorescamine.

Authors:  P Böhlen; S Stein; J Stone; S Udenfriend
Journal:  Anal Biochem       Date:  1975-08       Impact factor: 3.365

2.  A peptide-like substance from pituitary that acts like morphine. I. Isolation.

Authors:  H Teschemacher; K E Opheim; B M Cox; A Goldstein
Journal:  Life Sci       Date:  1975-06-15       Impact factor: 5.037

3.  Antibodies as a means of isolating and characterizing biologically active substances: presence of a non-peptide, morphine-like compound in the central nervous system.

Authors:  A R Gintzler; A Levy; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

4.  Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.

Authors:  C H Li; D Chung
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

5.  Isolation, primary structure, and synthesis of alpha-endorphin and gamma-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity.

Authors:  N Ling; R Burgus; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1976-11       Impact factor: 11.205

6.  Fluorometric assay of vasopressin and oxytocin: a general approach to the assay of peptides in tissues.

Authors:  K A Gruber; S Stein; L Brink; A Radhakrishnan; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

7.  Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness.

Authors:  F Bloom; D Segal; N Ling; R Guillemin
Journal:  Science       Date:  1976-11-05       Impact factor: 47.728

8.  Purification and partial chemical characterization of human pituitary lipolytic hormone.

Authors:  M Chrétien; C Gilardeau; N Seidah; M Lis
Journal:  Can J Biochem       Date:  1976-09

9.  Identification of two related pentapeptides from the brain with potent opiate agonist activity.

Authors:  J Hughes; T W Smith; H W Kosterlitz; L A Fothergill; B A Morgan; H R Morris
Journal:  Nature       Date:  1975-12-18       Impact factor: 49.962

10.  Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells.

Authors:  R E Mains; B A Eipper
Journal:  J Biol Chem       Date:  1976-07-10       Impact factor: 5.157
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  22 in total

1.  Purification to homogeneity of camel pituitary pro-opiocortin, the common precursor of opioid peptides and corticotropin.

Authors:  S Kimura; R V Lewis; L D Gerber; L Brink; M Rubinstein; S Stein; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

2.  Characterization of pro-opiocortin, a precursor to opioid peptides and corticotropin.

Authors:  M Rubinstein; S Stein; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

3.  beta-Lipotropin is the major opioid-like peptide of human pituitary and rat pars distalis: lack of significant beta-endorphin.

Authors:  A S Liotta; T Suda; D T Krieger
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

4.  Homology between a prolyl hydroxylase subunit and a tissue protein that crossreacts immunologically with the enzyme.

Authors:  S Chen-Kiang; G J Cardinale; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

5.  Competitive inhibition of benzodiazepine binding by fractions from porcine brain.

Authors:  G D Colello; D M Hockenbery; H B Bosmann; S Fuchs; K Folkers
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

6.  High molecular weight opioid-containing proteins in striatum.

Authors:  R V Lewis; S Stein; L D Gerber; M Rubinstein; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1978-08       Impact factor: 11.205

7.  Isolation and characterization of the opioid peptides from rat pituitary: beta-endorphin.

Authors:  M Rubinstein; S Stein; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

8.  Presence of somatostatin-28-(1-12) in hypothalamus and pancreas.

Authors:  R Benoit; P Böhlen; N Ling; A Briskin; F Esch; P Brazeau; S Y Ying; R Guillemin
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

9.  Processing of enkephalin-containing peptides in isolated bovine adrenal chromaffin granules.

Authors:  G Fleminger; E Ezra; D L Kilpatrick; S Udenfriend
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

10.  Simultaneous assay of immunoreactive beta-lipotropin, gamma-lipotropin, and beta-endorphin in plasma of normal human subjects, patients with ACTH/lipotropin hypersecretory syndromes, and patients undergoing chronic hemodialysis.

Authors:  X Y Bertagna; W J Stone; W E Nicholson; C D Mount; D N Orth
Journal:  J Clin Invest       Date:  1981-01       Impact factor: 14.808
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