PURPOSE: To test the hypothesis that electroretinograms (ERGs) reflect luminance activity when measured at high temporal frequencies and chromatic activity when measured near 12 Hz. METHODS: The authors measured the responses to stimuli in which the output of red and green light-emitting diodes was modulated in counterphase at different ratios, varying the luminance content in the stimulus while keeping the red-green chromatic contrast and its phase constant. RESULTS: The high temporal frequency electroretinography was determined mainly by the luminance contrast. At 12 Hz, electroretinographic response amplitudes and phases primarily reflected the red-green chromatic content of the stimulus. Control experiments, performed with a deuteranopic subject and with stimuli that silenced the rods and S-cones, excluded an explanation based on intrusion from rod- and S-cone-driven responses. CONCLUSIONS: It now is possible to perform noninvasive measurements of basic electrophysiological properties of the luminance and chromatic pathways on a retinal level, and their disease-related changes, in human observers.
PURPOSE: To test the hypothesis that electroretinograms (ERGs) reflect luminance activity when measured at high temporal frequencies and chromatic activity when measured near 12 Hz. METHODS: The authors measured the responses to stimuli in which the output of red and green light-emitting diodes was modulated in counterphase at different ratios, varying the luminance content in the stimulus while keeping the red-green chromatic contrast and its phase constant. RESULTS: The high temporal frequency electroretinography was determined mainly by the luminance contrast. At 12 Hz, electroretinographic response amplitudes and phases primarily reflected the red-green chromatic content of the stimulus. Control experiments, performed with a deuteranopic subject and with stimuli that silenced the rods and S-cones, excluded an explanation based on intrusion from rod- and S-cone-driven responses. CONCLUSIONS: It now is possible to perform noninvasive measurements of basic electrophysiological properties of the luminance and chromatic pathways on a retinal level, and their disease-related changes, in human observers.
Authors: Neil R A Parry; Ian J Murray; Athanasios Panorgias; Declan J McKeefry; Barry B Lee; Jan Kremers Journal: J Physiol Date: 2012-05-14 Impact factor: 5.182
Authors: Kallene Summer Moreira Vidal; Diego Decleva; Mirella Telles Salgueiro Barboni; Balàzs Vince Nagy; Paulo Augusto Hidalgo de Menezes; Avinash Aher; Artur Martins Coutinho; Paula Squarzoni; Daniele de Paula Faria; Fabio Luis de Souza Duran; Carlos Alberto Buchpiguel; Jan Kremers; Geraldo Busatto Filho; Dora Fix Ventura Journal: Invest Ophthalmol Vis Sci Date: 2022-05-02 Impact factor: 4.925
Authors: Mellina M Jacob; Gobinda Pangeni; Bruno D Gomes; Givago S Souza; Manoel da Silva Filho; Luiz Carlos L Silveira; John Maguire; Neil R A Parry; Declan J McKeefry; Jan Kremers Journal: PLoS One Date: 2015-03-18 Impact factor: 3.240