Comparison of the clinical and economic outcomes between open and minimally invasive appendectomy and colectomy: evidence from a large commercial payer database.

BACKGROUND: Appendectomy and colectomy are commonly performed surgical procedures. Despite evidence demonstrating advantages with the minimally invasive surgical (MIS) approach, open procedures occur with greater prevalence. Therefore, there is still controversy as to whether the MIS approach is safer or more cost effective.
METHODS: A retrospective analysis was performed using a large commercial payer database. The data included information on 7,532 appendectomies and 2,745 colectomies. Data on the distribution of patient demographic and comorbidity characteristics associated with the MIS and open approaches were reviewed. The corresponding complication rates and expenditures were analyzed. Summary statistics were compared using chi-square tests, and generalized linear models were constructed to estimate expenditures while controlling for patient characteristics.
RESULTS: The patients undergoing MIS and open colectomy showed no significant variations in age distribution or marginal age differences for appendectomy. Significantly more patients experienced an infection postoperatively, and procedure-specific complications were more common in the open group for both procedures (P\0.05). The postsurgical hospital stay was longer for the patients treated using the open techniques, differing an average of half a day for appendectomies and significantly more (4 days) for colectomy (P\0.05). Readmission rates differed little between the two approaches. Procedures performed through an MIS approach were associated with lower expenditures than for the open technique, with differences ranging from $700 for appendectomy patients (P\0.05) to $15,200 for colectomy patients (P\0.05).
CONCLUSIONS: Minimally invasive appendectomy and colectomy were associated with lower infection rates, fewer complications, shorter hospital stays, and lower expenditures than open surgery.

Minimally invasive surgery (MIS) as an option for a variety of abdominal surgical procedures has grown increasingly common in recent years [1-11]. The general motivations for choosing MIS approaches have remained stable despite the wide variability in anatomic sites and procedure indications. Advocates argue that MIS techniques are more likely to reduce intraoperative blood loss, decrease pain, and shorten postsurgical convalescence [12, 13]. These benefits have been shown to translate into improved health-related quality of life for patients, and in some cases, reduction in health care expenditures [14-17]. However, even when evidence of MIS benefits is strong, as is the case for some surgeries, researchers have found that surgeon preference and resident training convention are frequently the most powerful predictors when the choice is made between MIS and the conventional (open) approach [18].

The results of randomized controlled clinical trials comparing open surgeries with their minimally invasive equivalents vary widely by trial design, surgeon experience, and MIS approach. This variability has fostered a reluctance of surgeons to accept the advantages of the minimally invasive approaches over conventional open techniques. Observational studies afford a complementary approach to randomized controlled trials in determining the potential benefits (and associated significance) of MIS versus open surgeries. Although randomized controlled trials are considered the “gold standard” for assessing safety and efficacy, observational studies offer several potential advantages, including the ability to assess multiple risk factors associated with a very large population base. For instance, the current study uses a database containing more than 14 million unique admissions. Such a large population often is more representative of the patients undergoing these surgeries, making the results obtained from observational studies more generalizable in terms of clinical and economic outcomes.

The decision to perform MIS instead of open surgery may have significant health policy implications. Where evidence supports improved health outcomes and shorter convalescence for patients, MIS approaches are likely to improve health-related quality of life. Insurers and hospital administrators also may exert preferences regarding hospital length of stay because this factor influences prospective payments and hospital operating margins.

Appendectomy and colectomy provide the opportunity to study outcomes from surgical decisions made in vastly different situations and with diverse patient considerations. Appendectomy often is an emergency procedure performed for otherwise healthy adults. The choice of surgical method is made quickly (vs. days or weeks), and the surgery often is performed using the MIS approach. Colectomy, on the other hand, usually is a planned procedure performed for older individuals who often have additional health concerns. The choice of surgical approach is made after many aspects of the patient’s history and clinical status have been considered, and the surgery is more likely to be performed using open techniques [7, 10, 11]. Thus, appendectomy and colectomy afford the opportunity to compare and contrast MIS and open surgical outcomes from decisions made under differing circumstances.

The following analysis focuses on two commonly performed surgical procedures, appendectomy and colectomy, and the selected clinical and utilization outcomes associated with each.

Materials and methods

Database description

A retrospective analysis was performed using medical and pharmacy claims data and enrollment information from a large, fee-for-service U.S.-managed health care insurer. In 2005, the database contained more than 14 million individuals with both medical and pharmacy coverage. Physicians, facilities, and pharmacies submitted claims to the health plan insurer for payment covering services or prescription medications provided. For reimbursement purposes, the health plan requires service providers to include complete and accurate diagnosis and procedure information on medical claims submitted for payment. All study data used to perform this analysis were de-identified and accessed using protocols compliant with the Health Insurance Portability and Accountability Act (HIPAA), and no identifiable protected health information was extracted for the study.

Inclusion criteria

The two evaluated surgeries were appendectomy and colectomy. The inclusion criteria required that patients (1) had undergone one of these two surgeries between July 1, 2005 and June 30, 2006 and (2) were continuously enrolled in the health plan during this period as well as the 6 months before and after the date of their procedure. Patients were not excluded for surgeries performed for malignant conditions, an indication commonly observed in colectomy.

Open abdominal and MIS procedures were recorded according to the American Medical Association’s Current Procedural Terminology (CPT) codes. Specifically, open abdominal colectomies include procedures with the CPT codes 44140, 44143, 44145, and 44146, whereas the CPT codes for laparoscopic (MIS) colectomies are 44204, 44206, 44207, and 44208. Similarly, the open abdominal appendectomy CPT codes are 44950 and 44955, whereas the CPT code for laparoscopic (MIS) appendectomy is 44970.

Charlson Comorbidity Index

The validity of the conclusions drawn from data obtained from large administrative databases mandates that the variable disease severity and the variety of comorbid illnesses be accounted for in the analysis. This was especially important for the current study because colectomy is more frequently performed in abdominal surgery as a part of the treatment for cancer, whereas appendectomy is more likely to be accomplished using laparoscopic methods for otherwise healthy individuals.

The Charlson Comorbidity Index (CCI), tailored for use with medical records, is based on the International Classification of Diseases (ICD-9-CM) diagnosis and procedure codes found in administrative databases. The CCI predicts the 1-year mortality rate for a patient with a range of comorbid conditions (22 conditions). Each comorbid condition is assigned a score of 1, 2, 3, or 6 depending on the mortality risk associated with this condition. The scores are summed and given a total score predicting mortality [19].

The CCI was tested for associations with dichotomous outcome measures such as complications from various comorbid conditions including cancer, mortality, and blood transfusion [20]. We also accounted for disease severity by modeling procedure-related expenditures incurred before the index procedure. This incorporated procedures and medical care related to the diagnosis and management of the patient before surgery.

Patient characteristics and clinical and economic outcomes

Data on the following patient characteristics were extracted: patient age, geographic residence, whether a patient’s surgeon was a general surgeon or belonged to another specialty, and comorbidity severity using the CCI. Patient outcomes of interest, assessed over a 6-month follow-up period after the surgery, included both intra- and postoperative complications. Specifically, these outcomes consisted of overall infection rate, infection type, length of antibiotic use, number of major and minor bleeding episodes, and procedure-specific complication rates. Data on the length of hospital stay and rates of readmission also were collected. The economic variables included insurer and patient payment totals, cost capture of the surgical procedure, and expenditures related to follow-up office visits, emergency room visits, and hospitalizations.

The initial data capture included additional procedures for the abdomen. Patients were considered to have experienced a postsurgical infection if a claim was made for any of the following diagnoses: pulmonary infection, intraabdominal abscess or suppurative peritonitis, rectal abscess, retroperitoneal infection, infection of colostomy or enterostomy, urinary tract infection, breast abscess, pelvic organ infection, cellulites and skin abscess, local skin infection, acute lymphadenitis, sepsis, posttraumatic wound infection, or infection as a complication of care. Patients also were considered to have experienced a postsurgical infection if antibiotics were initiated within 3 days after surgery.

Patients were considered to have a diagnosis of bleeding if they had an ICD-9 code consistent with pathologic bleeding (Appendix) and fulfilled any one of the following criteria: history of a procedure-specific complication, an ICD-9 code consistent with a procedure used to control bleeding, or an ICD-9 code for blood transfusion with at least 2 units of packed red blood cells. Procedure-specific complications were defined for a period of 30 days after the surgery and included diagnoses of complications associated with the performance of the procedure as well as any diagnoses listed in the Appendix.

In this economic analysis, total expenditures for health care use directly associated with a patient’s surgery were estimated. These expenditures comprised insurer and patient payments including the cost of the surgical procedure and all of the clinical events previously described. Also included were expenditures related to follow-up office visits, emergency room visits, and hospitalizations. Because the dates of these services were between 2005 and 2006, all expenditures were converted to 2006 U.S. dollars using the consumer price index (CPI).

Statistical analysis

Bivariate comparisons between MIS and open abdominal procedures were made using t tests for continuous variables and chi-square tests for proportions. To model the expenditure for an episode of care, we used a generalized linear modeling (GLM) framework constructed using a gamma distribution and logarithmic link function [21, 22]. The reason for this approach is that expenditures are typically right-skewed. To address this issue, we estimated GLM gamma models. Findings have shown these models to be more efficient than alternative approaches such as semi-log models [21, 23]. The regression equation was used to estimate the effect of MIS and open abdominal surgery on health care expenditures separately for inpatient and outpatient procedures while controlling for observed covariates including an indicator for surgical approach, patient age, CCI, geographic region, and physician specialty. The predicted differences in expenditures between minimally invasive and open procedures then were bootstrapped (a general purpose approach to estimation) with 200 replications to estimate standard errors and confidence intervals [24].

The same GLM approach was adopted to estimate the duration of a care episode and the length of inpatient stay. Logistic regression was used to assess the probability of admission or readmission at days 30 and 60 after the surgery.

Results

Appendectomy

Between 1 July 2005 and 30 June 2006, the database identified 10,277 patients who met the study’s inclusion criteria. Appendectomies were performed using predominantly an MIS approach. Of the 7,532 patients who underwent appendectomies, 5,304 (70%) had MIS surgery and 2,228 (30%) had open abdominal surgery (Table 1).

Table 1

Number of patients per procedure for minimally invasive surgery (MIS) versus open surgerya

	n (%)	Mean age	0–17 years n (%)	18–34 years n (%)	35–64 years n (%)	65+ years n (%)	Male/female n (%)	CCI
Colectomy
MIS	842 (31)	54.7 ± 11.9	2 (0.2)	40 (4.8)	648 (77.0)	152 (18.1)	435/407 (51.7/48.3)	1.1 ± 1.6a
Open	1,903 (69)	55.4 ± 12.8	9 (0.5)	78 (4.1)	1,463 (76.9)	353 (18.6)	1,016/887 (53.4/48.3)	1.8 ± 2.1a
Appendectomy
MIS	5,304 (70)	33.9 ± 15.4	949 (17.9)a	1,820 (34.3)a	2,436 (45.9)a	99 (1.9)a	2,664/2,640 (50.2/49.8)	0.2 ± 0.6a
Open	2,228 (30)	33.5 ± 17.2	541 (24.3)a	625 (28.1)a	1,005 (45.1)a	57 (2.6)a	1,155/1,073 (51.8/48.2)a	0.3 ± 0.9a

CCI Charlson Comorbidity Index, MIS minimally invasive surgery

a P < 0.05 MIS vs. open surgery

Age was divided into four strata: 0–17 years, 18–34 years, 35–64 years, and 65 years or older. Although significant age differences were observed among the patients undergoing appendectomy, the overall pattern was ambiguous. Approximately 18 and 34% of the patients who underwent MIS appendectomy fell into the 0- to 17-year and 18- to 34-year strata, respectively. Similarly, approximately 24 and 28% of the patients who underwent open appendectomy fell into the 0- to 17-year and 18- to 34-year strata, respectively (P < 0.05 for both).

Table 2 reports postprocedural complications including infection rates, duration of associated antibiotic use, minor and major bleeding episodes, and procedure-specific complication rates. Significantly more appendectomy patients treated with open abdominal surgery experienced an infection postoperatively (P < 0.05). However, these significant differences in infection rates between MIS and open surgery were not reflected in days of antibiotics use. Significantly more incidences of minor and major bleeds occurred after appendectomies performed with open surgery (P < 0.05). Furthermore, procedure-specific complications were significantly more common for patients treated with an open approach (P < 0.05).

Table 2

Postprocedure complications for minimally invasive surgery (MIS) versus open surgery by procedurea

	Total	Any infection n (%)	Days of antibiotic/patient	Minor bleed n (%)	Major bleed n (%)	Procedure-specific complication ratea
Colectomy
MIS	842	203 (24)b	12.23 ± 17.81	141 (17)b	34 (4)b	5.93 ± 11.82b
Open	1,903	728 (38)b	16.46 ± 19.66	443 (23)b	187 (10)b	8.56 ± 12.40b
Appendectomy
MIS	5,304	863 (16)b	10.84 ± 9.04	328 (6)	61 (1)b	2.51 ± 3.96b
Open	2,228	435 (20)b	11.83 ± 13.29	153 (7)	48 (2)b	3.82 ± 6.84b

MIS minimally invasive surgery

aRate refers to the number of complications within 30 days of procedure

b P < 0.05, MIS vs open surgery

The sites of postprocedure infections by MIS versus open surgery are shown in Table 3. Intraabdominal, pulmonary, urinary, and skin infections were the most frequent for both MIS and open procedures. Infections were significantly more frequent (P < 0.05) for appendectomies performed using open versus MIS techniques.

Table 3

Percentage of patients with specific postprocedure infections for minimally invasive surgery (MIS) versus open surgery by procedurea

	Total	Any infection n (%)	Pulmonary n (%)	Intraabdominal abscess n (%)	Rectal abscess N (%)	Retroperitoneal N (%)	Colostomy/enterostomy n (%)	Urinary n (%)	Cellulitis/Skin n (%)	Wound n (%)	Sepsis N (%)	Miscellaneous: others n (%)
Colectomy
MIS	842	203 (24)a	32 (16)	93 (46)	5 (2)	0 (0)	1 (< 1)	39 (19)	41 (20)	1 (<1)	10 (5)a	1 (<1)
Open	1,903	728 (38)a	129 (18)	363 (50)	11 (2)	3 (0)	9 (1)	155 (21)	126 (17)	5 (1)	103 (14)a	20 (3)
Appendectomy
MIS	5,304	863 (16)a	123 (14)	381 (44)a	7 (1)	1 (<1)	0 (0)	241 (28)	134 (16)	9 (1)	33 (4)a	21 (2)
Open	2,228	435 (20)a	74 (17)	164 (38)a	0 (0)	1 (<1)	0 (0)	101 (23)	78 (18)	4 (1)	37 (9)a	14 (3)

MIS minimally invasive surgery

a P < 0.05

The predicted length of hospital stay using GLM models and the unadjusted number of readmission/admissions for MIS and open procedures are shown in Table 4. These models were adjusted for surgical approach (MIS vs. open procedure), patient age, baseline CCI, geographic region, physician specialty, and whether the procedure was conducted in an inpatient or outpatient setting. The postsurgical length of stay was consistently longer for patients treated using conventional open surgical techniques, with an average difference of about a half day for appendectomy patients (P < 0.05). Readmissions rates generally differed little between the MIS and open approaches.

Table 4

Generalized linear modeling (GLM) estimates for index length of stay and unadjusted number of readmission/admission for minimally invasive surgery (MIS) versus open surgery by procedure

	Total n	LOS (days)a Mean ± SEb	Mean no. of readmissions
			Day 30	Day 60	Day 90	Day 180
Colectomy	2,479
MIS		6.46 ± 0.17c	1.07 ± 0.26	1.00 ± 0.00c	1.15 ± 0.38	1.00 ± 0.00
Open		10.66 ± 0.25c	1.10 ± 0.33	1.07 ± 0.26c	1.02 ± 0.15	1.05 ± 0.22
Appendectomy	4,717
MIS		3.27 ± 0.04c	1.09 ± 0.29	1.10 ± 0.30	1.10 ± 0.00	1.00 ± 0.00
Open		3.91 ± 0.08c	1.07 ± 0.25	1.00 ± 0.00	1.08 ± 0.28	1.00 ± 0.00

SE standard error of the mean, MIS minimally invasive surgery

aIndex length of stay

bBootstrapped standard errors obtained using 200 bootstrap repetitions

c P < 0.05, MIS vs. open surgery

Expenditures and duration of care are shown in Table 5. Whereas duration of care did not vary for appendectomy procedures, expenditures for episodes of care varied. Appendectomy procedures performed using an MIS route were associated with a lower adjusted cost for an episode of care than their open equivalents, with differences of approximately $700.

Table 5

Duration and costs for procedure-related episode of care for minimally invasive surgery (MIS) versus open surgery by procedure (report of multivariable findings)

	Duration of carea (days)Mean ± SE	Cost for episode of care ($)b Mean	Adjusted cost for episode of care ($)c Mean	Difference in means ($) n (95% CI)
Colectomy
MIS	117.64 ± 2.73d	27,031.37d	29,278.4d	15,181.37 (11,295.85–19,066.89)e
Open	128.15 ± 1.8d	47,091.40d	44,459.77d
Appendectomy
MIS	72.66 ± 1.08	11,298.16d	11,552.41d	700.66 (28.8–1,372.52)d
Open	74.82 ± 1.62	14,031.95d	12,253.07d

SE standard error of the mean, CI confidence interval; MIS, minimally invasive surgery

aDays from index date of the surgical procedure to the last related medical or pharmacy claim, bootstrapped estimation

bTotal cost of all claims during the duration of the care interval

cAdjusted for surgery type, patient age at index date, gender, Charlson Comorbidity Index, geographic region, and medical degree specialty

d P < 0.05, MIS vs. open surgery

e p < 0.001, MIS vs. open surgery

Colectomy

The majority of colectomies were performed using open abdominal techniques (Table 1). Of the 2,745 patients who underwent colectomies, 842 (31%) were treated using the MIS approach, whereas 1,903 (69%) had open abdominal surgeries.

Considering the age strata, the distribution of use rates for MIS and open abdominal colectomy were similar. Within the 35- to 64-year age category (the age stratum including the majority of the colectomy procedures [n = 2,111, 77%]), MIS colectomy was used for 648 patients (31%) and open abdominal colectomy for 1,463 patients (69%). Within the stratum of patients 65 years old or older, 505 procedures were performed, with MIS colectomy accounting for 152 of the procedures (30%) and open abdominal colectomies accounting for 353 procedures (70%).

Patients undergoing open colectomies experienced more infections postoperatively (Table 2). However, these statistically significant differences in infection rates between MIS and open surgery (P < 0.05) were not reflected in days of antibiotics use. Incidences of minor and major bleeds were significantly more common after open colectomy procedures (P < 0.05). Procedure-specific complications, similar to those observed for appendectomies, (Table 3), were more common for colectomy patients undergoing open surgery, with statistically significant differences (P < 0.05). Intraabdominal, pulmonary, urinary, and skin infections were the most frequent types of postcolectomy infections for both MIS and open procedures. Infections were more frequent with open than with MIS procedures, and this difference was statistically significant (P < 0.05).

The predicted length of hospital stay (Table 4), adjusted for surgical approach, patient age, baseline CCI, geographic region, physician specialty, and procedure locale, was 4 days longer on the average for patients undergoing open colectomy than for those treated with MIS (P < 0.05). There was little difference in readmission rates between MIS and open colectomies.

Duration of care (Table 5) and costs for episode of care varied significantly for colectomy. Colectomy procedures performed through an MIS approach were associated with $15,200 lower adjusted expenditures than their open equivalents (P < 0.05). Overall clinical and economic outcomes are summarized in Table 6.

Table 6

Summary of clinical and economic outcomes for minimally invasive surgery (MIS) versus open surgery by procedure

	Total no. of patients N	Procedure-specific complication ratea (%)	Length of hospital stay1 (days)	Adjusted difference in costsb ($)
Colectomy
MIS	842	5.93c	6.46c	M
Open	1,903	8.56c	10.66c	15,181.37 more dollarsc
Appendectomy
MIS	5,304	2.51c	3.27c	—
Open	2,228	3.82c	3.91c	700.66 more dollarsd

MIS minimally invasive surgery

aNumber of complications within 30 days of procedure

bAdjusted for surgery type, patient age on index date, gender, Charlson Comorbidity Index, geographic region, and medical degree specialty

c P < 0.05, MIS vs open surgery

d P < 0.001, MIS vs open surgery

Discussion

This analysis focused on clinical and economic outcomes as reflected in a real-world database associated with two commonly performed surgical procedures: appendectomy and colectomy. By stratifying these procedures according to surgical approach, significant variability in the use of minimally invasive techniques was discernable. Appendectomy was performed most commonly using MIS techniques, whereas open surgery was more frequently performed for colectomy. Furthermore, postoperative infections were more common for patients undergoing open procedures, as was the incidence of major bleeding.

Although these differences argue for an advantage of MIS over open surgery, they also must be analyzed within the context of the limitations associated with the design of this study. Given the retrospective nature of these analyses, it was not possible to control completely for patient characteristics that may correlate with outcome variables of interest. To address this challenge, a multivariable general linear model (GLM) that adjusted for observed variations in patient characteristics (patient age, CCI, geographic region, surgical approach, and physician specialty) was constructed.

Although multivariate analyses adjust for observed differences in patient characteristics, unobserved differences not included in this model may have biased the results. For example, surgeon skill and experience in performing MIS or open surgery affects safety and efficacy outcomes; however, it was not incorporated directly into our analysis. An attempt was made to adjust for it by differentiating between general, colorectal, and other surgeons.

There are also limitations in the measures of disease severity. We account for disease severity by modeling both the Charlson comorbidity index and procedure-related expenditures incurred before the index procedure. The latter in particular incorporates procedures and medical care related to diagnosing and managing of the patient before surgery. The weakness of this measure as a proxy is that it indirectly adjusts only for disease severity.

Another limitation of our study relates to the data source. Although claims data are valuable tools for evaluating health outcomes, utilization, and spending, they are collected in this database for payment purposes and not for research. The presence of a claim for a medication, for example, did not necessarily translate into its use. Furthermore, medications purchased over the counter did not appear in claims reports. Finally, coding inaccuracies may have biased the results, particularly if they occurred systematically.

Our findings are largely in agreement with those of previous studies comparing MIS with open abdominal procedures reported in the literature. One meta-analysis of several clinical trials evaluating colectomy concluded that patients managed with minimally invasive techniques were less likely to experience postoperative ileus or a wound infection [14]. A recently published Cochrane review of randomized controlled trials evaluating appendectomy found that patients treated with MIS techniques were less likely to experience an infection postoperatively. In addition, these patients were discharged from the hospital 1 day earlier than their open surgery counterparts [16].

Conclusion

The results of our study suggest that the MIS approach for appendectomy and colectomy has lower infection rates, fewer complications, and shorter hospitalizations than the open techniques. The economic benefits of MIS surgery also were documented in our study. Interestingly, the improved results with the MIS approach were realized in both urgent care and elective surgery regardless of the age or clinical health status of the patient. This supports the continued evolution of the MIS approach for surgical diseases of the abdomen, with clinical and economic data to support selecting the MIS approach first when appendectomy and colectomy are considered.

Table 7

Hemorrhage characteristics

Hemorrhage type	Codes
Minor hemorrhage/bleeding
Selected intraocular (eye)	ICD-9 364.41, 372.72
Hemopericardium (bleeding around the heart) and hemothorax (into the lung cavity)	ICD-9 423.0, 860.2, 860.3, 860.4, 860.5
Esophageal	ICD-9 456.0, 456.20, 530.7, 530.82
Unspecified hemorrhage	ICD-9 459.0
Gastric/duodenal/peptic/gastrojejunal ulcer with hemorrhage	ICD-9 531.0x, 531.2x, 531.4x, 531.6x, 532.0x, 532.2x, 532.4x, 532.6x, 533.0x, 533.2x, 533.4x, 533.6x, 534.0x, 534.2x, 534.4x
Other upper gastrointestinal hemorrhage	ICD-9 535.01, 535.11, 535.21, 535.31, 535.41, 535.51, 535.61, 537.83, 537.84
Lower gastrointestinal hemorrhage	ICD-9 562.02, 562.03, 562.12, 562.13, 569.3, 569.85, 569.86
Unspecified gastrointestinal hemorrhage	ICD-9 578.x
Hemoperitoneum (abdominal cavity)	ICD-9 568.81
Urinary tract hemorrhage	ICD-9 596.7 (hemorrhage into bladder wall), 599.7 (hematuria)
Hemorrhage in pregnancy	ICD-9 639.1 (delayed or excessive hemorrhage after abortion or ectopic/molar pregnancy), 640.8x, 640.9x, 641.1x, 641.3x, 641.8x, 641.9x, 666.0x, 666.1x, 666.2x
Respiratory system	ICD-9 784.7, 784.8, 786.3
Other	ICD-9 719.1x, 998.11, 998.12
Major hemorrhage/bleeding
Intracranial hemorrhage	ICD-9 430, 431, 432, 432.0, 432.1, 432.9, 852, 852.0, 852.00, 852.01, 852.02, 852.03, 852.04, 852.05,852.06, 852.09, 852.1, 852.10, 852.11, 852.12, 852.13, 852.14, 852.15, 852.16, 852.19, 852.2, 852.20, 852.21, 852.22, 852.23, 852.24, 852.25, 852.26, 852.29, 852.3, 852.30, 852.31, 852.32, 852.33, 852.34, 852.35, 852.36, 852.39, 852.4, 852.40, 852.41, 852.42, 852.43, 852.44, 852.45, 852.46, 852.49, 852.5, 852.50, 852.51, 852.52, 852.53, 852.54, 852.55, 852.56, 852.59, 853, 853.0, 853.00, 853.01, 853.02, 853.03, 853.04, 853.05, 853.06, 853.09, 853.1, 853.10, 853.11, 853.12, 853.13, 853.14, 853.15, 853.16, 853.19
Intraocular (eye)(selected)	ICD-9 360.43, 362.43, 362.81, 363.61, 363.62,379.23
Control of hemorrhage/bleeding
	ICD-9 02.13, 06.02, 06.92, 21.0x, 28.7, 34.03, 34.09, 38.8x, 39.3x, 39.41, 39.98, 42.33, 42.91, 44.4x, 44.91, 45.43, 49.95, 50.61, 54.12, 54.19, 57.93, 60.94, 75.8, 96.06, 96.14, 96.19
	CPT 30901-30906, 30915-30920, 31238, 32110, 32654, 42960-42962, 42970-42972, 43227, 43255, 43400, 43460, 43501-43502, 43840, 44366, 44378, 44391, 45317, 45334, 45382, 46614, 47350-47362, 49002, 52606, 57180, 59160
Blood transfusion
	HCPCS P9010, P9011, P9016, P9021, P9022, P9038, P9039, P9040, P9051, P9054, P9056, P9057, P9058
	ICD-9 99.03, 99.04

ICD International Classification of Diseases, CPT American Medical Association’s Current Procedural Terminology, HCPCS Healthcare Common Procedure Coding System