PURPOSE: We assessed the accuracy and reproducibility of non-calcified plaque quantification as simulated by a low-density stenosis in vessel phantoms using diameter and area measures, as well as the influence of vessel size and motion on quantification accuracy in dual-source computed tomography (DSCT). METHODS: Four phantoms (2, 2.5, 3, and 4 mm in luminal diameter) made from a radiopaque Lucite (126 +/- 23 Hounsfield units, HU) simulating a fixed radiolucent concentric coronary stenosis (7 +/- 2 HU, 50% luminal narrowing) were connected to a cardiac motion simulator. Stenosis quantification was based on area and diameter measurements. All measurements were highly reproducible (all ICC > or =0.95, p < 0.001). RESULTS: The mean measured degree of stenosis was 38.0 +/- 11.7% for a single diameter measurement, resulting in a mean relative error of 22.0 +/- 18.7%, decreasing with increasing phantom size (31.9 +/- 22.1%; 25.2 +/- 20.9%; 16.3 +/- 12.8%; 14.5 +/- 11.4%; for 2-, 2.5-, 3-, and 4-mm phantoms, respectively; p < 0.0001). Measurement accuracy significantly increased to 13.3 +/- 13.9% by using area measurement (p < 0.0001). The degree of stenosis was not significantly different when comparing a motioned image with an image at rest. CONCLUSION: DSCT enables highly reproducible quantification of low density stenosis, but underestimates the degree of stenosis, especially in small vessels. Area-based measurements reflect the true degree of stenosis with higher accuracy than diameter.
PURPOSE: We assessed the accuracy and reproducibility of non-calcified plaque quantification as simulated by a low-density stenosis in vessel phantoms using diameter and area measures, as well as the influence of vessel size and motion on quantification accuracy in dual-source computed tomography (DSCT). METHODS: Four phantoms (2, 2.5, 3, and 4 mm in luminal diameter) made from a radiopaque Lucite (126 +/- 23 Hounsfield units, HU) simulating a fixed radiolucent concentric coronary stenosis (7 +/- 2 HU, 50% luminal narrowing) were connected to a cardiac motion simulator. Stenosis quantification was based on area and diameter measurements. All measurements were highly reproducible (all ICC > or =0.95, p < 0.001). RESULTS: The mean measured degree of stenosis was 38.0 +/- 11.7% for a single diameter measurement, resulting in a mean relative error of 22.0 +/- 18.7%, decreasing with increasing phantom size (31.9 +/- 22.1%; 25.2 +/- 20.9%; 16.3 +/- 12.8%; 14.5 +/- 11.4%; for 2-, 2.5-, 3-, and 4-mm phantoms, respectively; p < 0.0001). Measurement accuracy significantly increased to 13.3 +/- 13.9% by using area measurement (p < 0.0001). The degree of stenosis was not significantly different when comparing a motioned image with an image at rest. CONCLUSION: DSCT enables highly reproducible quantification of low density stenosis, but underestimates the degree of stenosis, especially in small vessels. Area-based measurements reflect the true degree of stenosis with higher accuracy than diameter.
Authors: Andreas H Mahnken; Tobias Seyfarth; Thomas Flohr; Christopher Herzog; Jochen Stahl; Sven Stanzel; Axel Kuettner; Joachim E Wildberger; Rolf W Günther Journal: Invest Radiol Date: 2005-01 Impact factor: 6.016
Authors: Johannes Rieber; Oliver Meissner; Gregor Babaryka; Susanne Reim; Melanie Oswald; Andreas Koenig; Thomas M Schiele; Michael Shapiro; Karl Theisen; Maximilian F Reiser; Volker Klauss; Udo Hoffmann Journal: Coron Artery Dis Date: 2006-08 Impact factor: 1.439
Authors: Ammar Sarwar; Johannes Rieber; Eline A Q Mooyaart; Sujith K Seneviratne; Stuart L Houser; Fabian Bamberg; O Christopher Raffel; Rajiv Gupta; Mannudeep K Kalra; Homer Pien; Hang Lee; Thomas J Brady; Udo Hoffmann Journal: Radiology Date: 2008-08-18 Impact factor: 11.105
Authors: Dieter Ropers; Johannes Rixe; Katharina Anders; Axel Küttner; Ulrich Baum; Werner Bautz; Werner G Daniel; Stephan Achenbach Journal: Am J Cardiol Date: 2005-12-01 Impact factor: 2.778
Authors: Lars Husmann; Oliver Gaemperli; Tiziano Schepis; Hans Scheffel; Ines Valenta; Tobias Hoefflinghaus; Paul Stolzmann; Lotus Desbiolles; Bernhard A Herzog; Sebastian Leschka; Borut Marincek; Hatem Alkadhi; Philipp A Kaufmann Journal: Int J Cardiovasc Imaging Date: 2008-06-19 Impact factor: 2.357
Authors: S Yusuf; D Zucker; P Peduzzi; L D Fisher; T Takaro; J W Kennedy; K Davis; T Killip; E Passamani; R Norris Journal: Lancet Date: 1994-08-27 Impact factor: 79.321
Authors: Taylor Richards; Gregory M Sturgeon; Juan Carlos Ramirez-Giraldo; Geoffrey D Rubin; Lynne Hurwitz Koweek; William Paul Segars; Ehsan Samei Journal: J Med Imaging (Bellingham) Date: 2018-01-17