Literature DB >> 19716298

Fully automated synthesis and initial PET evaluation of [11C]PBR28.

Min Wang1, Karmen K Yoder, Mingzhang Gao, Bruce H Mock, Xiao-Ming Xu, Andrew J Saykin, Gary D Hutchins, Qi-Huang Zheng.   

Abstract

Fully automated synthesis and initial PET evaluation of a TSPO radioligand, [11C]PBR28 (N-(2-[11C]methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide), are reported. These results facilitate the potential preclinical and clinical PET studies of [11C]PBR28 in animals and humans.

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Year:  2009        PMID： 19716298      PMCID： PMC2743750          DOI： 10.1016/j.bmcl.2009.08.051

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

1.  Convenient gas phase bromination of [11C]methane and production of [11C]methyl triflate.

Authors:  B H Mock; G K Mulholland; M T Vavrek
Journal:  Nucl Med Biol       Date:  1999-05       Impact factor: 2.408

2.  Quantitative comparison of FBP, EM, and Bayesian reconstruction algorithms for the IndyPET scanner.

Authors:  Thomas Frese; Ned C Rouze; Charles A Bouman; Ken Sauer; Gary D Hutchins
Journal:  IEEE Trans Med Imaging       Date:  2003-02       Impact factor: 10.048

3.  Quantitative analyses of 18F-FEDAA1106 binding to peripheral benzodiazepine receptors in living human brain.

Authors:  Yota Fujimura; Yoko Ikoma; Fumihiko Yasuno; Tetsuya Suhara; Miho Ota; Ryohei Matsumoto; Shoko Nozaki; Akihiro Takano; Jun Kosaka; Ming-Rong Zhang; Ryuji Nakao; Kazutoshi Suzuki; Nobumasa Kato; Hiroshi Ito
Journal:  J Nucl Med       Date:  2006-01       Impact factor: 10.057

4.  Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE.

Authors:  Qi-Huang Zheng; Bruce H Mock
Journal:  Biomed Chromatogr       Date:  2005-11       Impact factor: 1.902

Review 5.  Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.

Authors:  Vassilios Papadopoulos; Mario Baraldi; Tomás R Guilarte; Thomas B Knudsen; Jean-Jacques Lacapère; Peter Lindemann; Michael D Norenberg; David Nutt; Abraham Weizman; Ming-Rong Zhang; Moshe Gavish
Journal:  Trends Pharmacol Sci       Date:  2006-07-05       Impact factor: 14.819

6.  Folate antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a novel class of antimetabolites with potent antimalarial and antibacterial activity.

Authors:  E F Elslager; J Clarke; L M Werbel; D F Worth; J Davoll
Journal:  J Med Chem       Date:  1972-08       Impact factor: 7.446

7.  A simple synthesis of [11C]methyl triflate.

Authors:  D M Jewett
Journal:  Int J Rad Appl Instrum A       Date:  1992-11

8.  Synthesis of [11C]FEDAA1106 as a new PET imaging probe of peripheral benzodiazepine receptor expression.

Authors:  Min Wang; Mingzhang Gao; Gary D Hutchins; Qi-Huang Zheng
Journal:  Eur J Med Chem       Date:  2008-08-13       Impact factor: 6.514

9.  Design, synthesis, and structure-activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands.

Authors:  Taketoshi Okubo; Ryoko Yoshikawa; Shigeyuki Chaki; Shigeru Okuyama; Atsuro Nakazato
Journal:  Bioorg Med Chem       Date:  2004-07-01       Impact factor: 3.641

10.  Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage.

Authors:  J Benavides; D Fage; C Carter; B Scatton
Journal:  Brain Res       Date:  1987-09-22       Impact factor: 3.252
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  10 in total

1.  Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer.

Authors:  Yajing Peng; Mi Li; Ben D Clarkson; Mariana Pehar; Patrick J Lao; Ansel T Hillmer; Todd E Barnhart; Bradley T Christian; Heather A Mitchell; Barbara B Bendlin; Matyas Sandor; Luigi Puglielli
Journal:  J Neurosci       Date:  2014-05-14       Impact factor: 6.167

2.  Influence of TSPO genotype on 11C-PBR28 standardized uptake values.

Authors:  Karmen K Yoder; Kwangsik Nho; Shannon L Risacher; Sungeun Kim; Li Shen; Andrew J Saykin
Journal:  J Nucl Med       Date:  2013-06-19       Impact factor: 10.057

3.  Positron Emission Tomography studies with [11C]PBR28 in the Healthy Rodent Brain: Validating SUV as an Outcome Measure of Neuroinflammation.

Authors:  Miklós Tóth; Janine Doorduin; Jenny Häggkvist; Andrea Varrone; Nahid Amini; Christer Halldin; Balázs Gulyás
Journal:  PLoS One       Date:  2015-05-21       Impact factor: 3.240

4.  Evaluating [11C]PBR28 PET for Monitoring Gut and Brain Inflammation in a Rat Model of Chemically Induced Colitis.

Authors:  E Kurtys; J Doorduin; U L M Eisel; R A J O Dierckx; E F J de Vries
Journal:  Mol Imaging Biol       Date:  2017-02       Impact factor: 3.488

5.  Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer's disease.

Authors:  Qing Wang; Yong Wang; Jingxia Liu; Courtney L Sutphen; Carlos Cruchaga; Tyler Blazey; Brian A Gordon; Yi Su; Charlie Chen; Joshua S Shimony; Beau M Ances; Nigel J Cairns; Anne M Fagan; John C Morris; Tammie L S Benzinger
Journal:  Neuroimage Clin       Date:  2019-03-13       Impact factor: 4.881

6.  Direct Comparison of [18F]F-DPA with [18F]DPA-714 and [11C]PBR28 for Neuroinflammation Imaging in the same Alzheimer's Disease Model Mice and Healthy Controls.

Authors:  Francisco R López-Picón; Thomas Keller; Diana Bocancea; Jatta S Helin; Anna Krzyczmonik; Semi Helin; Annelaure Damont; Frédéric Dollé; Juha O Rinne; Merja Haaparanta-Solin; Olof Solin
Journal:  Mol Imaging Biol       Date:  2021-09-20       Impact factor: 3.488

Review 7.  The 18-kDa Translocator Protein PET Tracers as a Diagnostic Marker for Neuroinflammation: Development and Current Standing.

Authors:  Priya Singh; Anupriya Adhikari; Deepika Singh; Chandraprakash Gond; Anjani Kumar Tiwari
Journal:  ACS Omega       Date:  2022-04-18

8.  Improved Automated Radiosynthesis of [(11)C]PBR28.

Authors:  Kiran Kumar Solingapuram Sai; Don Gage; Mike Nader; Robert H Mach; Akiva Mintz
Journal:  Sci Pharm       Date:  2015-06-19

9.  Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET.

Authors:  Anna M Barron; Masaki Tokunaga; Ming-Rong Zhang; Bin Ji; Tetsuya Suhara; Makoto Higuchi
Journal:  J Neuroinflammation       Date:  2016-08-31       Impact factor: 8.322

10.  In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration.

Authors:  Jeanette M Metzger; Colleen F Moore; Carissa A Boettcher; Kevin G Brunner; Rachel A Fleddermann; Helen N Matsoff; Henry A Resnikoff; Viktoriya Bondarenko; Timothy J Kamp; Timothy A Hacker; Todd E Barnhart; Patrick J Lao; Bradley T Christian; R Jerry Nickles; Catherine L Gallagher; James E Holden; Marina E Emborg
Journal:  NPJ Parkinsons Dis       Date:  2018-07-13
  10 in total

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