Literature DB >> 4625530

Folate antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a novel class of antimetabolites with potent antimalarial and antibacterial activity.

E F Elslager, J Clarke, L M Werbel, D F Worth, J Davoll.   

Abstract

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Year:  1972        PMID： 4625530     DOI： 10.1021/jm00278a008

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  4 in total

1.  Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Authors:  Alexis Nzila; Matthias Rottmann; Penchit Chitnumsub; Stevens M Kiara; Sumalee Kamchonwongpaisan; Cherdsak Maneeruttanarungroj; Supannee Taweechai; Bryan K S Yeung; Anne Goh; Suresh B Lakshminarayana; Bin Zou; Josephine Wong; Ngai Ling Ma; Margaret Weaver; Thomas H Keller; Veronique Dartois; Sergio Wittlin; Reto Brun; Yongyuth Yuthavong; Thierry T Diagana
Journal:  Antimicrob Agents Chemother       Date:  2010-03-29       Impact factor: 5.191

2.  Antimalarial activities of new pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives.

Authors:  Jian Guan; Quan Zhang; Michael O'Neil; Nicanor Obaldia; Arba Ager; Lucia Gerena; Ai J Lin
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

3.  Antileishmanial activities of 2,4-diaminoquinazoline putative dihydrofolate reductase inhibitors.

Authors:  J D Berman; M King; N Edwards
Journal:  Antimicrob Agents Chemother       Date:  1989-11       Impact factor: 5.191

4.  Fully automated synthesis and initial PET evaluation of [11C]PBR28.

Authors:  Min Wang; Karmen K Yoder; Mingzhang Gao; Bruce H Mock; Xiao-Ming Xu; Andrew J Saykin; Gary D Hutchins; Qi-Huang Zheng
Journal:  Bioorg Med Chem Lett       Date:  2009-08-15       Impact factor: 2.823
  4 in total

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