Literature DB >> 15803445

Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE.

Qi-Huang Zheng1, Bruce H Mock.   

Abstract

A general methodology for the rapid purification of carbon-11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid-phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [(11)C]raclopride, [(11)C]beta-CFT and [(11)C]choline from their unlabeled precursors.

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Year:  2005        PMID： 15803445     DOI： 10.1002/bmc.494

Source DB:  PubMed          Journal:  Biomed Chromatogr        ISSN： 0269-3879            Impact factor:   1.902


  4 in total

Review 1.  Microfluidics for positron emission tomography probe development.

Authors:  Ming-Wei Wang; Wei-Yu Lin; Kan Liu; Michael Masterman-Smith; Clifton Kwang-Fu Shen
Journal:  Mol Imaging       Date:  2010-08       Impact factor: 4.488

2.  Automated radiosynthesis of [11C]morphine for clinical investigation.

Authors:  Jinda Fan; Konrad Meissner; Gregory G Gaehle; Shihong Li; Evan D Kharasch; Robert H Mach; Zhude Tu
Journal:  Appl Radiat Isot       Date:  2010-11-11       Impact factor: 1.513

Review 3.  Tactics for preclinical validation of receptor-binding radiotracers.

Authors:  Susan Z Lever; Kuo-Hsien Fan; John R Lever
Journal:  Nucl Med Biol       Date:  2016-09-03       Impact factor: 2.408

4.  Fully automated synthesis and initial PET evaluation of [11C]PBR28.

Authors:  Min Wang; Karmen K Yoder; Mingzhang Gao; Bruce H Mock; Xiao-Ming Xu; Andrew J Saykin; Gary D Hutchins; Qi-Huang Zheng
Journal:  Bioorg Med Chem Lett       Date:  2009-08-15       Impact factor: 2.823
  4 in total

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