Literature DB >> 19710714

Closing the gap between genotype and phenotype.

Peter K Gregersen.   

Abstract

Making causative connections between genotypic and phenotypic variation is a major challenge for geneticists engaged in the study of human disease. A study drawing this connection for a type 1 diabetes risk locus now demonstrates the importance of focusing on specific quantitative traits and studying them in normal subjects.

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Year:  2009        PMID： 19710714     DOI： 10.1038/ng0909-958

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

1.  Merging and emerging cohorts: necessary but not sufficient.

Authors:  Francis S Collins; Teri A Manolio
Journal:  Nature       Date:  2007-01-18       Impact factor: 49.962

2.  Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis.

Authors:  Unsong Oh; Gregg Blevins; Caitlin Griffith; Nancy Richert; Dragan Maric; C Richard Lee; Henry McFarland; Steven Jacobson
Journal:  Arch Neurol       Date:  2009-04

3.  The habitual, diverse and surmountable obstacles to human immunology research.

Authors:  Adrian C Hayday; Mark Peakman
Journal:  Nat Immunol       Date:  2008-06       Impact factor: 25.606

4.  Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Authors:  Jeffrey C Barrett; Sarah Hansoul; Dan L Nicolae; Judy H Cho; Richard H Duerr; John D Rioux; Steven R Brant; Mark S Silverberg; Kent D Taylor; M Michael Barmada; Alain Bitton; Themistocles Dassopoulos; Lisa Wu Datta; Todd Green; Anne M Griffiths; Emily O Kistner; Michael T Murtha; Miguel D Regueiro; Jerome I Rotter; L Philip Schumm; A Hillary Steinhart; Stephan R Targan; Ramnik J Xavier; Cécile Libioulle; Cynthia Sandor; Mark Lathrop; Jacques Belaiche; Olivier Dewit; Ivo Gut; Simon Heath; Debby Laukens; Myriam Mni; Paul Rutgeerts; André Van Gossum; Diana Zelenika; Denis Franchimont; Jean-Pierre Hugot; Martine de Vos; Severine Vermeire; Edouard Louis; Lon R Cardon; Carl A Anderson; Hazel Drummond; Elaine Nimmo; Tariq Ahmad; Natalie J Prescott; Clive M Onnie; Sheila A Fisher; Jonathan Marchini; Jilur Ghori; Suzannah Bumpstead; Rhian Gwilliam; Mark Tremelling; Panos Deloukas; John Mansfield; Derek Jewell; Jack Satsangi; Christopher G Mathew; Miles Parkes; Michel Georges; Mark J Daly
Journal:  Nat Genet       Date:  2008-06-29       Impact factor: 38.330

5.  Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.

Authors:  Calliope A Dendrou; Vincent Plagnol; Erik Fung; Jennie H M Yang; Kate Downes; Jason D Cooper; Sarah Nutland; Gillian Coleman; Matthew Himsworth; Matthew Hardy; Oliver Burren; Barry Healy; Neil M Walker; Kerstin Koch; Willem H Ouwehand; John R Bradley; Nicholas J Wareham; John A Todd; Linda S Wicker
Journal:  Nat Genet       Date:  2009-08-23       Impact factor: 38.330

Review 6.  The biology of interleukin-2.

Authors:  Thomas R Malek
Journal:  Annu Rev Immunol       Date:  2008       Impact factor: 28.527

Review 7.  Recent advances in the genetics of autoimmune disease.

Authors:  Peter K Gregersen; Lina M Olsson
Journal:  Annu Rev Immunol       Date:  2009       Impact factor: 28.527

8.  Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Authors:  Christopher E Lowe; Jason D Cooper; Todd Brusko; Neil M Walker; Deborah J Smyth; Rebecca Bailey; Kirsi Bourget; Vincent Plagnol; Sarah Field; Mark Atkinson; David G Clayton; Linda S Wicker; John A Todd
Journal:  Nat Genet       Date:  2007-08-05       Impact factor: 38.330

9.  Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Authors:  Jeffrey C Barrett; David G Clayton; Patrick Concannon; Beena Akolkar; Jason D Cooper; Henry A Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Vincent Plagnol; Flemming Pociot; Helen Schuilenburg; Deborah J Smyth; Helen Stevens; John A Todd; Neil M Walker; Stephen S Rich
Journal:  Nat Genet       Date:  2009-05-10       Impact factor: 38.330

10.  A prescription for human immunology.

Authors:  Mark M Davis
Journal:  Immunity       Date:  2008-12-19       Impact factor: 31.745
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  5 in total

Review 1.  Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.

Authors:  Robert M Plenge; Soumya Raychaudhuri
Journal:  Rheum Dis Clin North Am       Date:  2010-05       Impact factor: 2.670

2.  GWASs and the age of human as the model organism for autoimmune genetic research.

Authors:  Robert Plenge
Journal:  Genome Biol       Date:  2010-05-05       Impact factor: 13.583

3.  Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children.

Authors:  Yann C Klimentidis; Jasmin Divers; Krista Casazza; T Mark Beasley; David B Allison; Jose R Fernandez
Journal:  Hum Genomics       Date:  2011-01       Impact factor: 4.639

4.  Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease.

Authors:  Tim Raine; Jimmy Z Liu; Carl A Anderson; Miles Parkes; Arthur Kaser
Journal:  Gut       Date:  2014-05-05       Impact factor: 23.059

5.  Analysis of menstrual effluent: diagnostic potential for endometriosis.

Authors:  Laura A Warren; Andrew Shih; Susana Marquez Renteira; Tamer Seckin; Brandon Blau; Kim Simpfendorfer; Annette Lee; Christine N Metz; Peter K Gregersen
Journal:  Mol Med       Date:  2018-03-19       Impact factor: 6.354
  5 in total

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