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Literature DB >> 18587394

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

Jeffrey C Barrett¹, Sarah Hansoul, Dan L Nicolae, Judy H Cho, Richard H Duerr, John D Rioux, Steven R Brant, Mark S Silverberg, Kent D Taylor, M Michael Barmada, Alain Bitton, Themistocles Dassopoulos, Lisa Wu Datta, Todd Green, Anne M Griffiths, Emily O Kistner, Michael T Murtha, Miguel D Regueiro, Jerome I Rotter, L Philip Schumm, A Hillary Steinhart, Stephan R Targan, Ramnik J Xavier, Cécile Libioulle, Cynthia Sandor, Mark Lathrop, Jacques Belaiche, Olivier Dewit, Ivo Gut, Simon Heath, Debby Laukens, Myriam Mni, Paul Rutgeerts, André Van Gossum, Diana Zelenika, Denis Franchimont, Jean-Pierre Hugot, Martine de Vos, Severine Vermeire, Edouard Louis, Lon R Cardon, Carl A Anderson, Hazel Drummond, Elaine Nimmo, Tariq Ahmad, Natalie J Prescott, Clive M Onnie, Sheila A Fisher, Jonathan Marchini, Jilur Ghori, Suzannah Bumpstead, Rhian Gwilliam, Mark Tremelling, Panos Deloukas, John Mansfield, Derek Jewell, Jack Satsangi, Christopher G Mathew, Miles Parkes, Michel Georges, Mark J Daly.

Abstract

Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease (a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

Entities: Disease Gene Mutation Species

Mesh：

Year: 2008 PMID： 18587394 PMCID： PMC2574810 DOI： 10.1038/ng.175

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

48 in total

1. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease.

Authors: Keiko Yamazaki; Dermot McGovern; Jiannis Ragoussis; Marta Paolucci; Helen Butler; Derek Jewell; Lon Cardon; Masakazu Takazoe; Torao Tanaka; Toshiki Ichimori; Susumu Saito; Akihiro Sekine; Aritoshi Iida; Atsushi Takahashi; Tatsuhiko Tsunoda; Mark Lathrop; Yusuke Nakamura
Journal: Hum Mol Genet Date: 2005-10-12 Impact factor: 6.150

2. Population structure, differential bias and genomic control in a large-scale, case-control association study.

Authors: David G Clayton; Neil M Walker; Deborah J Smyth; Rebecca Pask; Jason D Cooper; Lisa M Maier; Luc J Smink; Alex C Lam; Nigel R Ovington; Helen E Stevens; Sarah Nutland; Joanna M M Howson; Malek Faham; Martin Moorhead; Hywel B Jones; Matthew Falkowski; Paul Hardenbol; Thomas D Willis; John A Todd
Journal: Nat Genet Date: 2005-10-09 Impact factor: 38.330

3. Integrating case-control and TDT studies.

Authors: G R Kazeem; M Farrall
Journal: Ann Hum Genet Date: 2005-05 Impact factor: 1.670

4. Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

Authors: Lindsey A Criswell; Kirsten A Pfeiffer; Raymond F Lum; Bonnie Gonzales; Jill Novitzke; Marlena Kern; Kathy L Moser; Ann B Begovich; Victoria E H Carlton; Wentian Li; Annette T Lee; Ward Ortmann; Timothy W Behrens; Peter K Gregersen
Journal: Am J Hum Genet Date: 2005-02-17 Impact factor: 11.025

5. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.

Authors: C Tysk; E Lindberg; G Järnerot; B Flodérus-Myrhed
Journal: Gut Date: 1988-07 Impact factor: 23.059

6. Enhanced production of monocyte chemotactic protein 3 in inflammatory bowel disease mucosa.

Authors: J Wedemeyer; A Lorentz; M Göke; P N Meier; P Flemming; C A Dahinden; M P Manns; S C Bischoff
Journal: Gut Date: 1999-05 Impact factor: 23.059

7. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6.

Authors: David Yen; Jeanne Cheung; Heleen Scheerens; Frédérique Poulet; Terrill McClanahan; Brent McKenzie; Melanie A Kleinschek; Alex Owyang; Jeanine Mattson; Wendy Blumenschein; Erin Murphy; Manjiri Sathe; Daniel J Cua; Robert A Kastelein; Donna Rennick
Journal: J Clin Invest Date: 2006-05 Impact factor: 14.808

8. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.

Authors: Nunzio Bottini; Lucia Musumeci; Andres Alonso; Souad Rahmouni; Konstantina Nika; Masoud Rostamkhani; James MacMurray; Gian Franco Meloni; Paola Lucarelli; Maurizio Pellecchia; George S Eisenbarth; David Comings; Tomas Mustelin
Journal: Nat Genet Date: 2004-03-07 Impact factor: 38.330

9. The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells.

Authors: Atsushi Nakazawa; Iris Dotan; Jens Brimnes; Matthieu Allez; Ling Shao; Fumihiko Tsushima; Miyuki Azuma; Lloyd Mayer
Journal: Gastroenterology Date: 2004-05 Impact factor: 22.682

10. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

Authors: Miles Parkes; Jeffrey C Barrett; Natalie J Prescott; Mark Tremelling; Carl A Anderson; Sheila A Fisher; Roland G Roberts; Elaine R Nimmo; Fraser R Cummings; Dianne Soars; Hazel Drummond; Charlie W Lees; Saud A Khawaja; Richard Bagnall; Denis A Burke; Catherine E Todhunter; Tariq Ahmad; Clive M Onnie; Wendy McArdle; David Strachan; Graeme Bethel; Claire Bryan; Cathryn M Lewis; Panos Deloukas; Alastair Forbes; Jeremy Sanderson; Derek P Jewell; Jack Satsangi; John C Mansfield; Lon Cardon; Christopher G Mathew
Journal: Nat Genet Date: 2007-06-06 Impact factor: 38.330

1161 in total

1. LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation.

Authors: Cara Skon-Hegg; Juan Zhang; Xiumin Wu; Meredith Sagolla; Naruhisa Ota; Arthur Wuster; Jennifer Tom; Emma Doran; Nandhini Ramamoorthi; Patrick Caplazi; John Monroe; Wyne P Lee; Timothy W Behrens
Journal: J Immunol Date: 2018-12-03 Impact factor: 5.422

2. A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.

Authors: Yuta Kochi; Yukinori Okada; Akari Suzuki; Katsunori Ikari; Chikashi Terao; Atsushi Takahashi; Keiko Yamazaki; Naoya Hosono; Keiko Myouzen; Tatsuhiko Tsunoda; Naoyuki Kamatani; Tatsuya Furuichi; Shiro Ikegawa; Koichiro Ohmura; Tsuneyo Mimori; Fumihiko Matsuda; Takuji Iwamoto; Shigeki Momohara; Hisashi Yamanaka; Ryo Yamada; Michiaki Kubo; Yusuke Nakamura; Kazuhiko Yamamoto
Journal: Nat Genet Date: 2010-05-09 Impact factor: 38.330

3. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Authors: Eli A Stahl; Soumya Raychaudhuri; Elaine F Remmers; Gang Xie; Stephen Eyre; Brian P Thomson; Yonghong Li; Fina A S Kurreeman; Alexandra Zhernakova; Anne Hinks; Candace Guiducci; Robert Chen; Lars Alfredsson; Christopher I Amos; Kristin G Ardlie; Anne Barton; John Bowes; Elisabeth Brouwer; Noel P Burtt; Joseph J Catanese; Jonathan Coblyn; Marieke J H Coenen; Karen H Costenbader; Lindsey A Criswell; J Bart A Crusius; Jing Cui; Paul I W de Bakker; Philip L De Jager; Bo Ding; Paul Emery; Edward Flynn; Pille Harrison; Lynne J Hocking; Tom W J Huizinga; Daniel L Kastner; Xiayi Ke; Annette T Lee; Xiangdong Liu; Paul Martin; Ann W Morgan; Leonid Padyukov; Marcel D Posthumus; Timothy R D J Radstake; David M Reid; Mark Seielstad; Michael F Seldin; Nancy A Shadick; Sophia Steer; Paul P Tak; Wendy Thomson; Annette H M van der Helm-van Mil; Irene E van der Horst-Bruinsma; C Ellen van der Schoot; Piet L C M van Riel; Michael E Weinblatt; Anthony G Wilson; Gert Jan Wolbink; B Paul Wordsworth; Cisca Wijmenga; Elizabeth W Karlson; Rene E M Toes; Niek de Vries; Ann B Begovich; Jane Worthington; Katherine A Siminovitch; Peter K Gregersen; Lars Klareskog; Robert M Plenge
Journal: Nat Genet Date: 2010-05-09 Impact factor: 38.330

4. Replication in genome-wide association studies.

Authors: Peter Kraft; Eleftheria Zeggini; John P A Ioannidis
Journal: Stat Sci Date: 2009-11-01 Impact factor: 2.901

5. Candidate genes versus genome-wide associations: which are better for detecting genetic susceptibility to infectious disease?

Authors: W Amos; E Driscoll; J I Hoffman
Journal: Proc Biol Sci Date: 2010-10-06 Impact factor: 5.349

6. LRRK2 is involved in the IFN-gamma response and host response to pathogens.

Authors: Agnès Gardet; Yair Benita; Chun Li; Bruce E Sands; Isabel Ballester; Christine Stevens; Joshua R Korzenik; John D Rioux; Mark J Daly; Ramnik J Xavier; Daniel K Podolsky
Journal: J Immunol Date: 2010-10-04 Impact factor: 5.422

7. A meta-analysis on the association between three promoter variants of TNF-α and Crohn's disease.

Authors: Cui Xie; Xiao Feng Liu; Mao Sheng Yang
Journal: Mol Biol Rep Date: 2011-06-03 Impact factor: 2.316

8. Association of TNFSF15 polymorphism with irritable bowel syndrome.

Authors: Marco Zucchelli; Michael Camilleri; Anna Nixon Andreasson; Francesca Bresso; Aldona Dlugosz; Jonas Halfvarson; Leif Törkvist; Peter T Schmidt; Pontus Karling; Bodil Ohlsson; Richard H Duerr; Magnus Simren; Greger Lindberg; Lars Agreus; Paula Carlson; Alan R Zinsmeister; Mauro D'Amato
Journal: Gut Date: 2011-06-02 Impact factor: 23.059

Review 9. Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes.

Authors: Altin Gjymishka; Roxana M Coman; Todd M Brusko; Sarah C Glover
Journal: Immunotherapy Date: 2013-12 Impact factor: 4.196

10. What can we learn from inflammatory bowel disease in developing countries?

Authors: Sunny H Wong; Siew C Ng
Journal: Curr Gastroenterol Rep Date: 2013-03