Literature DB >> 20510233

Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.

Robert M Plenge1, Soumya Raychaudhuri.   

Abstract

The purpose of this article is to place these genetic discoveries in the context of current and future therapeutic strategies for patients with RA. More specifically, this article focuses on (1) a brief overview of genetic studies, (2) human genetics as an approach to identify the Achilles heel of disease pathways, (3) humans as the model organism for functional studies of human mutations, (4) pharmacogenetic studies to gain insight into the mechanism of action of drugs, and (5) next-generation patient registries to enable large-scale genotype-phenotype studies.

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Year:  2010        PMID： 20510233      PMCID： PMC2879392          DOI： 10.1016/j.rdc.2010.03.002

Source DB:  PubMed          Journal:  Rheum Dis Clin North Am        ISSN： 0889-857X            Impact factor:   2.670


  68 in total

1.  DANBIO: a nationwide registry of biological therapies in Denmark.

Authors:  M L Hetland
Journal:  Clin Exp Rheumatol       Date:  2005 Sep-Oct       Impact factor: 4.473

2.  Abatacept.

Authors:  Larry Moreland; Guy Bate; Peter Kirkpatrick
Journal:  Nat Rev Drug Discov       Date:  2006-03       Impact factor: 84.694

3.  Optimalization of the clinical pharmacogenetic model to predict methotrexate treatment response: the influence of the number of haplotypes of MTHFR 1298A-677C alleles on probability to respond.

Authors:  W M Kooloos; J A M Wessels; S M van der Kooij; C F Allaart; T W J Huizinga; H-J Guchelaar
Journal:  Ann Rheum Dis       Date:  2009-08       Impact factor: 19.103

4.  Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity.

Authors:  Petter S Woll; Colin H Martin; Jeffrey S Miller; Dan S Kaufman
Journal:  J Immunol       Date:  2005-10-15       Impact factor: 5.422

5.  Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development.

Authors:  Elias T Zambidis; Bruno Peault; Tea Soon Park; Fred Bunz; Curt I Civin
Journal:  Blood       Date:  2005-04-14       Impact factor: 22.113

6.  Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

Authors:  Robert M Plenge; Leonid Padyukov; Elaine F Remmers; Shaun Purcell; Annette T Lee; Elizabeth W Karlson; Frederick Wolfe; Daniel L Kastner; Lars Alfredsson; David Altshuler; Peter K Gregersen; Lars Klareskog; John D Rioux
Journal:  Am J Hum Genet       Date:  2005-11-01       Impact factor: 11.025

7.  Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis.

Authors:  Michael H Weisman; Daniel E Furst; Grace S Park; Joel M Kremer; Katie M Smith; Daniel J Wallace; Jacques R Caldwell; Thierry Dervieux
Journal:  Arthritis Rheum       Date:  2006-02

8.  Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

Authors:  Soumya Raychaudhuri; Robert M Plenge; Elizabeth J Rossin; Aylwin C Y Ng; Shaun M Purcell; Pamela Sklar; Edward M Scolnick; Ramnik J Xavier; David Altshuler; Mark J Daly
Journal:  PLoS Genet       Date:  2009-06-26       Impact factor: 5.917

9.  REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.

Authors:  Peter K Gregersen; Chistopher I Amos; Annette T Lee; Yue Lu; Elaine F Remmers; Daniel L Kastner; Michael F Seldin; Lindsey A Criswell; Robert M Plenge; V Michael Holers; Ted R Mikuls; Tuulikki Sokka; Larry W Moreland; S Louis Bridges; Gang Xie; Ann B Begovich; Katherine A Siminovitch
Journal:  Nat Genet       Date:  2009-06-07       Impact factor: 38.330

10.  Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.

Authors:  Torkel Vang; Mauro Congia; Maria Doloretta Macis; Lucia Musumeci; Valeria Orrú; Patrizia Zavattari; Konstantina Nika; Lutz Tautz; Kjetil Taskén; Francesco Cucca; Tomas Mustelin; Nunzio Bottini
Journal:  Nat Genet       Date:  2005-11-06       Impact factor: 38.330
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  3 in total

Review 1.  Genetic markers as therapeutic target in rheumatoid arthritis: A game changer in clinical therapy?

Authors:  A M Mohamed Thoufic Ali; S Vino
Journal:  Rheumatol Int       Date:  2016-09-16       Impact factor: 2.631

Review 2.  Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy.

Authors:  Nitya Nair; Henrik E Mei; Shih-Yu Chen; Matthew Hale; Garry P Nolan; Holden T Maecker; Mark Genovese; C Garrison Fathman; Chan C Whiting
Journal:  Arthritis Res Ther       Date:  2015-05-18       Impact factor: 5.156

3.  Ultrasonographic assessment of enthesitis in HLA-B27 positive patients with rheumatoid arthritis, a matched case-only study.

Authors:  Antonio Mera-Varela; Aida Ferreiro-Iglesias; Eva Perez-Pampin; Marisol Porto-Silva; Juan J Gómez-Reino; Antonio Gonzalez
Journal:  PLoS One       Date:  2013-03-07       Impact factor: 3.240
  3 in total

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