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Literature DB >> 19669474

Dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation.

Abstract

The dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation (DBS) were studied using two models, a simple firing-rate model and a population-based model. We extended the simple firing-rate model of the complex formed by the subthalamic nucleus (STN) and the external segment of the Globus Pallidus (GPe) to explore its dynamical regime during DBS. More specifically, the modulation of neuronal activity (i.e., pattern and amplitude) during DBS was studied. A similar approach was used with the population-based model. Simulation results revealed a gradual decrease in bursting activity in STN cells when the DBS frequency increased. In addition, the contribution of the stimulation current type (mono- or biphasic) to the results was also examined. A comparison of the two models indicated that the population-based model was more biologically realistic and more appropriate for exploring DBS mechanisms. Understanding the underlying mechanisms of DBS is a prerequisite for developing new stimulation protocols.

Entities: Disease

Year: 2008 PMID： 19669474 PMCID： PMC2585637 DOI： 10.1007/s10867-008-9095-y

Source DB: PubMed Journal: J Biol Phys ISSN： 0092-0606 Impact factor: 1.365

36 in total

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Authors: C Beurrier; B Bioulac; J Audin; C Hammond
Journal: J Neurophysiol Date: 2001-04 Impact factor: 2.714

2. Activity patterns in a model for the subthalamopallidal network of the basal ganglia.

Authors: D Terman; J E Rubin; A C Yew; C J Wilson
Journal: J Neurosci Date: 2002-04-01 Impact factor: 6.167

3. High-frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor.

Authors: R Levy; W D Hutchison; A M Lozano; J O Dostrovsky
Journal: J Neurosci Date: 2000-10-15 Impact factor: 6.167

Review 4. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.

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Journal: Prog Brain Res Date: 1990 Impact factor: 2.453

Review 5. Electrical stimulation of excitable tissue: design of efficacious and safe protocols.

Authors: Daniel R Merrill; Marom Bikson; John G R Jefferys
Journal: J Neurosci Methods Date: 2005-02-15 Impact factor: 2.390

6. Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease.

Authors: Noa Fogelson; Andrea A Kühn; Paul Silberstein; Patricia Dowsey Limousin; Marwan Hariz; Thomas Trottenberg; Andreas Kupsch; Peter Brown
Journal: Neurosci Lett Date: 2005-03-16 Impact factor: 3.046

7. Subthalamic oscillatory activities at beta or higher frequency do not change after high-frequency DBS in Parkinson's disease.

Authors: G Foffani; G Ardolino; M Egidi; E Caputo; B Bossi; A Priori
Journal: Brain Res Bull Date: 2005-12-13 Impact factor: 4.077

Dynamics of the subthalamo-pallidal complex in Parkinson's disease during deep brain stimulation.

1. High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons.

2. Activity patterns in a model for the subthalamopallidal network of the basal ganglia.

3. High-frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor.

Review 4. Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions.

Review 5. Electrical stimulation of excitable tissue: design of efficacious and safe protocols.

6. Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease.

7. Subthalamic oscillatory activities at beta or higher frequency do not change after high-frequency DBS in Parkinson's disease.

Review 8. The functional anatomy of basal ganglia disorders.

9. GABAergic interneurons in human subthalamic nucleus.

10. Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease.

1. Complexity in neurology and psychiatry.

2. Delta oscillations are a robust biomarker of dopamine depletion severity and motor dysfunction in awake mice.

3. Modeling shifts in the rate and pattern of subthalamopallidal network activity during deep brain stimulation.

Review 4. Systems approaches to optimizing deep brain stimulation therapies in Parkinson's disease.

5. Mechanism of suppression of sustained neuronal spiking under high-frequency stimulation.

6. Variable but not random: temporal pattern coding in a songbird brain area necessary for song modification.

7. Using a hybrid neuron in physiologically inspired models of the basal ganglia.

8. Efficient implementation of a real-time estimation system for thalamocortical hidden Parkinsonian properties.

9. Computational Stimulation of the Basal Ganglia Neurons with Cost Effective Delayed Gaussian Waveforms.