| Literature DB >> 15911112 |
Noa Fogelson1, Andrea A Kühn, Paul Silberstein, Patricia Dowsey Limousin, Marwan Hariz, Thomas Trottenberg, Andreas Kupsch, Peter Brown.
Abstract
Excessive synchronisation of basal ganglia activity at frequencies < 30 Hz is a hallmark of the parkinsonian state, and may contribute to bradykinesia. Accordingly, we electrically stimulated chronically implanted subthalamic macroelectrodes in 10 Parkinson's disease patients, after overnight withdrawal of anti-parkinsonian medication. We compared the effects of stimulation at 0, 5, 10, 15, 20, 25, 30, and ca. 130 Hz by measuring kinesia time (KT) in a tapping task. Although the effects of direct stimulation were small, frequency-response curves demonstrated local peaks at 5-10 Hz and at 20-25 Hz, superimposed upon an overall tendency for KT to reduce with increasing stimulation frequency. This is consistent with the hypothesis that spontaneous activities in these bands might promote bradykinesia.Entities:
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Year: 2005 PMID： 15911112 DOI： 10.1016/j.neulet.2005.02.050
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046