Literature DB >> 15389990

Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease.

Lars Timmermann1, Lars Wojtecki, Joachim Gross, Ralph Lehrke, Jürgen Voges, Mohammed Maarouf, Harald Treuer, Volker Sturm, Alfons Schnitzler.   

Abstract

Recently, a pathological oscillatory network at 10 Hz including several motor areas was described in patients with idiopathic Parkinson's disease (PD). In 7 PD patients, we tested the clinical effect of subthalamic nucleus (STN) stimulation at varying frequencies 1 to 3 years after implantation of electrodes. STN stimulation at 10 Hz induced significant worsening of motor symptoms, especially akinesia, compared with no stimulation and therapeutic stimulation (> or =130 Hz). This finding indicates the clinical relevance of pathological 10 Hz synchronization in PD.

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Year:  2004        PMID： 15389990     DOI： 10.1002/mds.20198

Source DB:  PubMed          Journal:  Mov Disord        ISSN： 0885-3185            Impact factor:   10.338


  59 in total

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