Literature DB >> 19657341

RecQ helicases: multifunctional genome caretakers.

Wai Kit Chu1, Ian D Hickson.   

Abstract

Around 1% of the open reading frames in the human genome encode predicted DNA and RNA helicases. One highly conserved group of DNA helicases is the RecQ family. Genetic defects in three of the five human RecQ helicases, BLM, WRN and RECQ4, give rise to defined syndromes associated with cancer predisposition, some features of premature ageing and chromosomal instability. In recent years, there has been a tremendous advance in our understanding of the cellular functions of individual RecQ helicases. In this Review, we discuss how these proteins might suppress genomic rearrangements, and therefore function as 'caretaker' tumour suppressors.

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Year:  2009        PMID： 19657341     DOI： 10.1038/nrc2682

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  132 in total

1.  CHROMOSOMAL BREAKAGE IN A RARE AND PROBABLY GENETICALLY DETERMINED SYNDROME OF MAN.

Authors:  J GERMAN; R ARCHIBALD; D BLOOM
Journal:  Science       Date:  1965-04-23       Impact factor: 47.728

Review 2.  Structure and function of RecQ DNA helicases.

Authors:  Richard J Bennett; James L Keck
Journal:  Crit Rev Biochem Mol Biol       Date:  2004 Mar-Apr       Impact factor: 8.250

3.  Clonal lines of aneuploid cells in Rothmund-Thomson syndrome.

Authors:  V M Der Kaloustian; J J McGill; M Vekemans; H R Kopelman
Journal:  Am J Med Genet       Date:  1990-11

Review 4.  DNA helicases required for homologous recombination and repair of damaged replication forks.

Authors:  Leonard Wu; Ian D Hickson
Journal:  Annu Rev Genet       Date:  2006       Impact factor: 16.830

5.  Resolution of converging replication forks by RecQ and topoisomerase III.

Authors:  Catherine Suski; Kenneth J Marians
Journal:  Mol Cell       Date:  2008-06-20       Impact factor: 17.970

6.  Analysis of helicase activity and substrate specificity of Drosophila RECQ5.

Authors:  A Zeynep Ozsoy; Heather M Ragonese; Steven W Matson
Journal:  Nucleic Acids Res       Date:  2003-03-01       Impact factor: 16.971

7.  Enhanced tumor formation in mice heterozygous for Blm mutation.

Authors:  Kathleen Heppner Goss; Mary A Risinger; Jennifer J Kordich; Maureen M Sanz; Joel E Straughen; Lisa E Slovek; Anthony J Capobianco; James German; Gregory P Boivin; Joanna Groden
Journal:  Science       Date:  2002-09-20       Impact factor: 47.728

8.  Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.

Authors:  Amitabh V Nimonkar; A Zeynep Ozsoy; Jochen Genschel; Paul Modrich; Stephen C Kowalczykowski
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-29       Impact factor: 11.205

Review 9.  Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.

Authors:  Patricia L Opresko
Journal:  Mech Ageing Dev       Date:  2007-10-30       Impact factor: 5.432

Review 10.  Chromosome fragile sites.

Authors:  Sandra G Durkin; Thomas W Glover
Journal:  Annu Rev Genet       Date:  2007       Impact factor: 16.830
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  249 in total

Review 1.  SF1 and SF2 helicases: family matters.

Authors:  Margaret E Fairman-Williams; Ulf-Peter Guenther; Eckhard Jankowsky
Journal:  Curr Opin Struct Biol       Date:  2010-04-22       Impact factor: 6.809

2.  Efficient coupling of ATP hydrolysis to translocation by RecQ helicase.

Authors:  Behzad Rad; Stephen C Kowalczykowski
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-17       Impact factor: 11.205

3.  The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.

Authors:  Lynda M Groocock; John Prudden; J Jefferson P Perry; Michael N Boddy
Journal:  Mol Cell Biol       Date:  2011-11-07       Impact factor: 4.272

4.  Purification of a novel RECQL5-SWI/SNF-RNAPII super complex.

Authors:  Guangjin Zhou; Yifei Liu; Shwu-Yuan Wu; Feng Tie; Hua Lou; Cheng-Ming Chiang; Guangbin Luo
Journal:  Int J Biochem Mol Biol       Date:  2010-07-15

5.  Initiation of DNA double strand break repair: signaling and single-stranded resection dictate the choice between homologous recombination, non-homologous end-joining and alternative end-joining.

Authors:  Anastazja Grabarz; Aurélia Barascu; Josée Guirouilh-Barbat; Bernard S Lopez
Journal:  Am J Cancer Res       Date:  2012-04-21       Impact factor: 6.166

6.  Synergic and opposing activities of thermophilic RecQ-like helicase and topoisomerase 3 proteins in Holliday junction processing and replication fork stabilization.

Authors:  Anna Valenti; Mariarita De Felice; Giuseppe Perugino; Anna Bizard; Marc Nadal; Mosè Rossi; Maria Ciaramella
Journal:  J Biol Chem       Date:  2012-06-21       Impact factor: 5.157

7.  An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.

Authors:  Chi-Fu Chen; Steven J Brill
Journal:  EMBO J       Date:  2010-04-13       Impact factor: 11.598

8.  A strand invasion 3' polymerization intermediate of mammalian homologous recombination.

Authors:  Weiduo Si; Maureen M Mundia; Alissa C Magwood; Adam L Mark; Richard D McCulloch; Mark D Baker
Journal:  Genetics       Date:  2010-03-22       Impact factor: 4.562

9.  RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase.

Authors:  M Nurul Islam; David Fox; Rong Guo; Takemi Enomoto; Weidong Wang
Journal:  Mol Cell Biol       Date:  2010-03-15       Impact factor: 4.272

10.  The Bacteroides sp. 3_1_23 Pif1 protein is a multifunctional helicase.

Authors:  Na-Nv Liu; Xiao-Lei Duan; Xia Ai; Yan-Tao Yang; Ming Li; Shuo-Xing Dou; Stephane Rety; Eric Deprez; Xu-Guang Xi
Journal:  Nucleic Acids Res       Date:  2015-09-17       Impact factor: 16.971
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