Benjamin Feiner1, Fuad Fares, Nail Azam, Ron Auslender, Miriam David, Yoram Abramov. 1. Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Carmel Medical Center, Technion University Medical School, Haifa, Israel. feiner@tx.technion.ac.il
Abstract
INTRODUCTION AND HYPOTHESIS: COLIA1 polymorphism is associated with increased risk for stress urinary incontinence. We hypothesize that a similar association exists with pelvic organ prolapse (POP). METHODS: Patients with advanced prolapse and healthy controls were evaluated by interview, validated questionnaires, and pelvic examination. DNA was extracted from peripheral blood, and polymerase chain reaction was performed to determine the presence or absence of the polymorphism. Power calculation indicated the need for 36 patients in each arm. RESULTS: The prevalence of the polymorphic heterozygous genotype (GT) in the study and control groups was 33.3% and 19.4%, respectively, leading to an odds ratio of 1.75. This difference, however, did not reach statistical significance (p = 0.27). CONCLUSIONS: The COLIA1 polymorphism was not significantly associated with increased risk for POP.
INTRODUCTION AND HYPOTHESIS: COLIA1 polymorphism is associated with increased risk for stress urinary incontinence. We hypothesize that a similar association exists with pelvic organ prolapse (POP). METHODS:Patients with advanced prolapse and healthy controls were evaluated by interview, validated questionnaires, and pelvic examination. DNA was extracted from peripheral blood, and polymerase chain reaction was performed to determine the presence or absence of the polymorphism. Power calculation indicated the need for 36 patients in each arm. RESULTS: The prevalence of the polymorphic heterozygous genotype (GT) in the study and control groups was 33.3% and 19.4%, respectively, leading to an odds ratio of 1.75. This difference, however, did not reach statistical significance (p = 0.27). CONCLUSIONS: The COLIA1 polymorphism was not significantly associated with increased risk for POP.
Authors: R C Bump; A Mattiasson; K Bø; L P Brubaker; J O DeLancey; P Klarskov; B L Shull; A R Smith Journal: Am J Obstet Gynecol Date: 1996-07 Impact factor: 8.661
Authors: Stuart H Ralston; André G Uitterlinden; Maria Luisa Brandi; Susana Balcells; Bente L Langdahl; Paul Lips; Roman Lorenc; Barbara Obermayer-Pietsch; Serena Scollen; Mariona Bustamante; Lise Bjerre Husted; Alisoun H Carey; Adolfo Diez-Perez; Alison M Dunning; Alberto Falchetti; Elzbieta Karczmarewicz; Marcin Kruk; Johannes P T M van Leeuwen; Joyce B J van Meurs; Jon Mangion; Fiona E A McGuigan; Leonardo Mellibovsky; Francesca del Monte; Huibert A P Pols; Jonathan Reeve; David M Reid; Wilfried Renner; Fernando Rivadeneira; Natasja M van Schoor; Rachael E Sherlock; John P A Ioannidis Journal: PLoS Med Date: 2006-02-21 Impact factor: 11.069
Authors: Jennifer M Wu; Anthony G Visco; Elizabeth A Grass; Damian M Craig; Rebekah G Fulton; Carol Haynes; Cindy L Amundsen; Svati H Shah Journal: Am J Obstet Gynecol Date: 2012-01-31 Impact factor: 8.661
Authors: Jennifer M Wu; Renée M Ward; Kristina L Allen-Brady; Todd L Edwards; Peggy A Norton; Katherine E Hartmann; Elizabeth R Hauser; Digna R Velez Edwards Journal: Am J Obstet Gynecol Date: 2012-11-27 Impact factor: 8.661
Authors: Renée M Ward; Digna R Velez Edwards; Todd Edwards; Ayush Giri; Rebecca N Jerome; Jennifer M Wu Journal: Am J Obstet Gynecol Date: 2014-04-12 Impact factor: 8.661
Authors: Rufus Cartwright; Anna C Kirby; Kari A O Tikkinen; Altaf Mangera; Gans Thiagamoorthy; Prabhakar Rajan; Jori Pesonen; Chris Ambrose; Juan Gonzalez-Maffe; Phillip Bennett; Tom Palmer; Andrew Walley; Marjo-Riitta Järvelin; Chris Chapple; Vik Khullar Journal: Am J Obstet Gynecol Date: 2014-08-08 Impact factor: 8.661
Authors: Kristina Allen-Brady; John W F Chua; Romana Cuffolo; Marianne Koch; Felice Sorrentino; Rufus Cartwright Journal: Int Urogynecol J Date: 2021-04-24 Impact factor: 1.932